4C2J

Crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase in complex with CoA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	3-KETOACYL-COA THIOLASE, MITOCHONDRIAL	polymer	417	44161.4	4	UniProt (P42765) Pfam (PF00108) Pfam (PF02803) In PDB	HOMO SAPIENS (HUMAN)	ACETYL-COA ACYLTRANSFERASE, BETA-KETOTHIOLASE, MITOCHONDRIAL 3-OXOACYL-COA THIOLASE, T1,3-KETOACYL-COA THIOLASE
2	A, B, C, D	1,2-ETHANEDIOL	non-polymer		62.1	16	Chemie (EDO)
3	A, B, C, D	COENZYME A	non-polymer		767.5	4	Chemie (COA)
4		water	water		18.0	807	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 397 (UniProt: P42765)

PDB	External Database	Details
Met -19	-	expression tag
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	176645.7
Non-Polymers*	Number of molecules	20
	Total formula weight	4063.2
All*	Total formula weight	180708.9

*Water molecules are not included.