8PYZ
 
 | | Structure of Ompk36GD from Klebsiella pneumonia, solved at wavelength 4.13 A | | Descriptor: | (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, LAURYL DIMETHYLAMINE-N-OXIDE, OmpK36 | | Authors: | Duman, R, El Omari, K, Mykhaylyk, V, Orr, C, Kwong, H, Beis, K, Wagner, A. | | Deposit date: | 2023-07-26 | | Release date: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Experimental phasing opportunities for macromolecular crystallography at very long wavelengths.
Commun Chem, 6, 2023
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8PZ5
 | | Structure of ThcOx, solved at wavelength 3.099 A | | Descriptor: | FLAVIN MONONUCLEOTIDE, SagB-type dehydrogenase domain protein | | Authors: | Duman, R, El Omari, K, Mykhaylyk, V, Orr, C, Wagner, A. | | Deposit date: | 2023-07-27 | | Release date: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Experimental phasing opportunities for macromolecular crystallography at very long wavelengths.
Commun Chem, 6, 2023
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8QHR
 | | Crystal structure of the human DNPH1 glycosyl-enzyme intermediate | | Descriptor: | 1',2'-DIDEOXYRIBOFURANOSE-5'-PHOSPHATE, 1,2-ETHANEDIOL, 2'-deoxynucleoside 5'-phosphate N-hydrolase 1, ... | | Authors: | Rzechorzek, N.J, West, S.C. | | Deposit date: | 2023-09-09 | | Release date: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1.
Nat Commun, 14, 2023
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8QHQ
 | | Crystal structure of human DNPH1 bound to hmdUMP | | Descriptor: | 1,2-ETHANEDIOL, 2'-deoxynucleoside 5'-phosphate N-hydrolase 1, 5-HYDROXYMETHYLURIDINE-2'-DEOXY-5'-MONOPHOSPHATE | | Authors: | Rzechorzek, N.J, West, S.C. | | Deposit date: | 2023-09-09 | | Release date: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1.
Nat Commun, 14, 2023
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8T36
 | | Crystal structure of K49 acetylated LC3A in complex with the LIR of TP53INP2/DOR | | Descriptor: | 1,2-ETHANEDIOL, Tumor protein p53-inducible nuclear protein 2,Microtubule-associated proteins 1A/1B light chain 3A chimera | | Authors: | Ali, M.G.H, Wahba, H.M, Cyr, N, Omichinski, J.G. | | Deposit date: | 2023-06-07 | | Release date: | 2024-05-22 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (1.852 Å) | | Cite: | Structural and functional characterization of the role of acetylation on the interactions of the human Atg8-family proteins with the autophagy receptor TP53INP2/DOR.
Autophagy, 2024
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8T4T
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8T31
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8T33
 | | Crystal structure of K46 acetylated GABARAP in complex with the LIR of TP53INP2/DOR | | Descriptor: | ACETATE ION, Gamma-aminobutyric acid receptor-associated protein, Tumor protein p53-inducible nuclear protein 2, ... | | Authors: | Ali, M.G.H, Wahba, H.M, Cyr, N, Omichinski, J.G. | | Deposit date: | 2023-06-07 | | Release date: | 2024-05-22 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (1.599 Å) | | Cite: | Structural and functional characterization of the role of acetylation on the interactions of the human Atg8-family proteins with the autophagy receptor TP53INP2/DOR.
Autophagy, 2024
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8T35
 | | Crystal structure of K51 acetylated LC3A in complex with the LIR of TP53INP2/DOR | | Descriptor: | 1,2-ETHANEDIOL, Tumor protein p53-inducible nuclear protein 2,Microtubule-associated proteins 1A/1B light chain 3A | | Authors: | Ali, M.G.H, Wahba, H.M, Cyr, N, Omichinski, J.G. | | Deposit date: | 2023-06-07 | | Release date: | 2024-05-22 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (1.902 Å) | | Cite: | Structural and functional characterization of the role of acetylation on the interactions of the human Atg8-family proteins with the autophagy receptor TP53INP2/DOR.
Autophagy, 2024
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8T32
 | | Crystal structure of K48 acetylated GABARAP in complex with the LIR of TP53INP2/DOR | | Descriptor: | Gamma-aminobutyric acid receptor-associated protein, LIR of DOR, TRIETHYLENE GLYCOL | | Authors: | Ali, M.G.H, Wahba, H.M, Cyr, N, Omichinski, J.G. | | Deposit date: | 2023-06-07 | | Release date: | 2024-05-22 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (2.051 Å) | | Cite: | Structural and functional characterization of the role of acetylation on the interactions of the human Atg8-family proteins with the autophagy receptor TP53INP2/DOR.
Autophagy, 2024
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6F5M
 | | Crystal structure of highly glycosylated human leukocyte elastase in complex with a thiazolidinedione inhibitor | | Descriptor: | 5-[[4-[[(2~{S})-4-methyl-1-oxidanylidene-1-[(2-propylphenyl)amino]pentan-2-yl]carbamoyl]phenyl]methyl]-2-oxidanylidene-1,3-thiazol-1-ium-4-olate, ACETATE ION, Neutrophil elastase, ... | | Authors: | Hochscherf, J, Pietsch, M, Tieu, W, Kuan, K, Hautmann, S, Abell, A, Guetschow, M, Niefind, K. | | Deposit date: | 2017-12-01 | | Release date: | 2018-08-08 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of highly glycosylated human leukocyte elastase in complex with an S2' site binding inhibitor.
Acta Crystallogr F Struct Biol Commun, 74, 2018
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8QXJ
 | | Cryo-EM structure of tetrameric human SAMHD1 with dApNHpp | | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, FE (III) ION, ... | | Authors: | Acton, O.J, Sheppard, D, Rosenthal, P.B, Taylor, I.A. | | Deposit date: | 2023-10-24 | | Release date: | 2024-05-15 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (2.65 Å) | | Cite: | Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis.
Nat Commun, 15, 2024
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8QXL
 | | Cryo-EM structure of tetrameric human SAMHD1 State II - Hemi-relaxed | | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYCYTIDINE, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, ... | | Authors: | Acton, O.J, Sheppard, D, Rosenthal, P.B, Taylor, I.A. | | Deposit date: | 2023-10-24 | | Release date: | 2024-05-15 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (2.82 Å) | | Cite: | Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis.
Nat Commun, 15, 2024
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8QXM
 | | Cryo-EM structure of tetrameric human SAMHD1 State III - Relaxed | | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... | | Authors: | Acton, O.J, Sheppard, D, Rosenthal, P.B, Taylor, I.A. | | Deposit date: | 2023-10-24 | | Release date: | 2024-05-15 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (2.94 Å) | | Cite: | Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis.
Nat Commun, 15, 2024
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8QXN
 | | Cryo-EM structure of tetrameric human SAMHD1 State IV - Depleted relaxed | | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... | | Authors: | Acton, O.J, Sheppard, D, Rosenthal, P.B, Taylor, I.A. | | Deposit date: | 2023-10-24 | | Release date: | 2024-05-15 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (2.98 Å) | | Cite: | Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis.
Nat Commun, 15, 2024
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8QXK
 | | Cryo-EM structure of tetrameric human SAMHD1 State I - Tense | | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... | | Authors: | Acton, O.J, Sheppard, D, Rosenthal, P.B, Taylor, I.A. | | Deposit date: | 2023-10-24 | | Release date: | 2024-05-15 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (2.66 Å) | | Cite: | Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis.
Nat Commun, 15, 2024
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8QXO
 | | Cryo-EM structure of tetrameric human SAMHD1 State V - Depleted relaxed | | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, ... | | Authors: | Acton, O.J, Sheppard, D, Rosenthal, P.B, Taylor, I.A. | | Deposit date: | 2023-10-24 | | Release date: | 2024-05-15 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.43 Å) | | Cite: | Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis.
Nat Commun, 15, 2024
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5HH4
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8VK2
 | | X-ray crystal structure of human IgE 4C8 Fab | | Descriptor: | IgE 4C8 heavy chain, IgE 4C8 light chain | | Authors: | Khatri, K, Ball, A, Smith, S.A, Champan, M.D, Pomes, A, Chruszcz, M. | | Deposit date: | 2024-01-08 | | Release date: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (2.508 Å) | | Cite: | Structural analysis of human IgE monoclonal antibody epitopes on dust mite allergen Der p 2.
J.Allergy Clin.Immunol., 2024
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8VK1
 | | X-ray crystal structure of human IgE 4C8 Fab complex with Der p 2.0103 | | Descriptor: | Der p 2 variant 3, IgE 4C8 heavy chain, IgE 4C8 light chain | | Authors: | Khatri, K, Ball, A, Smith, S.A, Champan, M.D, Pomes, A, Chruszcz, M. | | Deposit date: | 2024-01-08 | | Release date: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (3.05 Å) | | Cite: | Structural analysis of human IgE monoclonal antibody epitopes on dust mite allergen Der p 2.
J.Allergy Clin.Immunol., 2024
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8VY6
 | | Murine light chain dimer | | Descriptor: | 6A8 light chain, SULFATE ION | | Authors: | Kapingidza, A.B, Dolamore, C, Hyduke, N.P, Easly, W, Chivv, C, Pomes, A, Chruszcz, M. | | Deposit date: | 2024-02-07 | | Release date: | 2024-07-03 | | Last modified: | 2024-07-10 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural, Biophysical, and Computational Studies of a Murine Light Chain Dimer.
Molecules, 29, 2024
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5HH6
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7V90
 | | Telomeric mononucleosome | | Descriptor: | DNA (145-mer), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | | Authors: | Soman, A. | | Deposit date: | 2021-08-24 | | Release date: | 2022-07-27 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Columnar structure of human telomeric chromatin.
Nature, 609, 2022
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7VA4
 | | Telomeric tetranucleosome in open state | | Descriptor: | DNA (539-MER), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | | Authors: | Soman, A. | | Deposit date: | 2021-08-27 | | Release date: | 2022-07-27 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (14 Å) | | Cite: | Columnar structure of human telomeric chromatin.
Nature, 609, 2022
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7V9J
 | | Telomeric trinucleosome | | Descriptor: | DNA (408-mer), Histone H2A type 1-B/E, Histone H2B type 1-K, ... | | Authors: | Soman, A. | | Deposit date: | 2021-08-25 | | Release date: | 2022-07-27 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (8 Å) | | Cite: | Columnar structure of human telomeric chromatin.
Nature, 609, 2022
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