8QHR

Crystal structure of the human DNPH1 glycosyl-enzyme intermediate

Summary for 8QHR

• Entry DOI: 10.2210/pdb8qhr/pdb
• Related: 8QHQ
• Descriptor: 2'-deoxynucleoside 5'-phosphate N-hydrolase 1, 1',2'-DIDEOXYRIBOFURANOSE-5'-PHOSPHATE, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: dnph1, n-glycosidase, hmdump, drp, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 33477.42

Authors

Rzechorzek, N.J.,West, S.C. (deposition date: 2023-09-09, release date: 2023-11-08)

• Primary citation: Rzechorzek, N.J.,Kunzelmann, S.,Purkiss, A.G.,Silva Dos Santos, M.,MacRae, J.I.,Taylor, I.A.,Fugger, K.,West, S.C.; Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1.; Nat Commun, 14:6809-6809, 2023; PubMed: 37884503; DOI: 10.1038/s41467-023-42544-4

Experimental method

X-RAY DIFFRACTION (1.65 Å)