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5X5B
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BU of 5x5b by Molmil
Prefusion structure of SARS-CoV spike glycoprotein, conformation 2
Descriptor: Spike glycoprotein
Authors:Yuan, Y, Cao, D, Zhang, Y, Ma, J, Qi, J, Wang, Q, Lu, G, Wu, Y, Yan, J, Shi, Y, Zhang, X, Gao, G.F.
Deposit date:2017-02-15
Release date:2017-05-03
Last modified:2017-05-24
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
Nat Commun, 8, 2017
5X59
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BU of 5x59 by Molmil
Prefusion structure of MERS-CoV spike glycoprotein, three-fold symmetry
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, S protein
Authors:Yuan, Y, Cao, D, Zhang, Y, Ma, J, Qi, J, Wang, Q, Lu, G, Wu, Y, Yan, J, Shi, Y, Zhang, X, Gao, G.F.
Deposit date:2017-02-15
Release date:2017-05-03
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
Nat Commun, 8, 2017
5X5C
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BU of 5x5c by Molmil
Prefusion structure of MERS-CoV spike glycoprotein, conformation 1
Descriptor: S protein
Authors:Yuan, Y, Cao, D, Zhang, Y, Ma, J, Qi, J, Wang, Q, Lu, G, Wu, Y, Yan, J, Shi, Y, Zhang, X, Gao, G.F.
Deposit date:2017-02-15
Release date:2017-05-03
Last modified:2017-05-24
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
Nat Commun, 8, 2017
3JA8
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BU of 3ja8 by Molmil
Cryo-EM structure of the MCM2-7 double hexamer
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Minichromosome Maintenance 2, Minichromosome Maintenance 3, ...
Authors:Li, N, Zhai, Y, Zhang, Y, Li, W, Yang, M, Lei, J, Tye, B.K, Gao, N.
Deposit date:2015-05-09
Release date:2015-08-05
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of the eukaryotic MCM complex at 3.8 angstrom
Nature, 524, 2015
3JCS
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BU of 3jcs by Molmil
2.8 Angstrom cryo-EM structure of the large ribosomal subunit from the eukaryotic parasite Leishmania
Descriptor: 26S alpha ribosomal RNA, 26S delta ribosomal RNA, 26S epsilon ribosomal RNA, ...
Authors:Shalev-Benami, M, Zhang, Y, Matzov, D, Halfon, Y, Zackay, A, Rozenberg, H, Zimmerman, E, Bashan, A, Jaffe, C.L, Yonath, A, Skiniotis, G.
Deposit date:2016-01-21
Release date:2016-07-20
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:2.8- angstrom Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.
Cell Rep, 16, 2016
7V9G
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BU of 7v9g by Molmil
Native BEN4 domain of protein Bend3 with DNA
Descriptor: BEN domain-containing protein 3, DNA (5'-D(*GP*CP*AP*CP*CP*GP*CP*GP*TP*GP*GP*GP*GP*CP*CP*A)-3'), DNA (5'-D(*TP*GP*GP*CP*CP*CP*CP*AP*CP*GP*CP*GP*GP*TP*GP*C)-3')
Authors:Zhang, J, Zhang, Y, You, Q, Huang, C, Zhang, T, Wang, M, Zhang, T, Yang, X, Xiong, J, Li, Y, Liu, C.P, Zhang, Z, Xu, R.M, Zhu, B.
Deposit date:2021-08-25
Release date:2022-02-16
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation.
Science, 375, 2022
7V9I
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BU of 7v9i by Molmil
The Monomer mutant of BEN4 domain of protein Bend3 with DNA
Descriptor: BEN domain-containing protein 3, DNA (5'-D(*AP*CP*CP*GP*CP*GP*TP*GP*GP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*CP*CP*AP*CP*GP*CP*GP*GP*T)-3')
Authors:Zhang, J, Zhang, Y, You, Q, Huang, C, Zhang, T, Wang, M, Zhang, T, Yang, X, Xiong, J, Li, Y, Liu, C.P, Zhang, Z, Xu, R.M, Zhu, B.
Deposit date:2021-08-25
Release date:2022-02-16
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation.
Science, 375, 2022
7V9H
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BU of 7v9h by Molmil
The BEN3 domain of protein Bend3
Descriptor: BEN domain-containing protein 3
Authors:Zhang, J, Zhang, Y, You, Q, Huang, C, Zhang, T, Wang, M, Zhang, T, Yang, X, Xiong, J, Li, Y, Liu, C.P, Zhang, Z, Xu, R.M, Zhu, B.
Deposit date:2021-08-25
Release date:2022-02-16
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.692 Å)
Cite:Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation.
Science, 375, 2022
7V9F
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BU of 7v9f by Molmil
Selenomethionine mutant (L740Sem) of BEN4 domain of protein Bend3 with DNA
Descriptor: BEN domain-containing protein 3, CITRIC ACID, DNA (5'-D(*GP*CP*AP*CP*CP*GP*CP*GP*TP*GP*GP*GP*GP*CP*CP*A)-3'), ...
Authors:Zhang, J, Zhang, Y, You, Q, Huang, C, Zhang, T, Wang, M, Zhang, T, Yang, X, Xiong, J, Li, Y, Liu, C.P, Zhang, Z, Xu, R.M, Zhu, B.
Deposit date:2021-08-25
Release date:2022-02-16
Last modified:2022-03-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation.
Science, 375, 2022
5X5F
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BU of 5x5f by Molmil
Prefusion structure of MERS-CoV spike glycoprotein, conformation 2
Descriptor: S protein
Authors:Yuan, Y, Cao, D, Zhang, Y, Ma, J, Qi, J, Wang, Q, Lu, G, Wu, Y, Yan, J, Shi, Y, Zhang, X, Gao, G.F.
Deposit date:2017-02-15
Release date:2017-05-03
Last modified:2017-05-24
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains
Nat Commun, 8, 2017
4MEX
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BU of 4mex by Molmil
Crystal structure of Escherichia coli RNA polymerase in complex with salinamide A
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Feng, Y, Zhang, Y, Arnold, E, Ebright, R.H.
Deposit date:2013-08-27
Release date:2014-05-21
Last modified:2014-06-25
Method:X-RAY DIFFRACTION (3.902 Å)
Cite:Transcription inhibition by the depsipeptide antibiotic salinamide A.
Elife, 3, 2014
4EAC
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BU of 4eac by Molmil
Crystal structure of mannonate dehydratase from Escherichia coli strain K12
Descriptor: CHLORIDE ION, MANGANESE (II) ION, Mannonate dehydratase
Authors:Qiu, X, Zhu, Y, Yuan, Y, Zhang, Y, Liu, H, Gao, Y, Teng, M, Niu, L.
Deposit date:2012-03-22
Release date:2013-03-27
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into decreased enzymatic activity induced by an insert sequence in mannonate dehydratase from Gram negative bacterium.
J.Struct.Biol., 180, 2012
7O6E
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BU of 7o6e by Molmil
2.12 A cryo-EM structure of Mycobacterium tuberculosis Ferritin
Descriptor: Ferritin BfrB
Authors:Gijsbers, A, Zhang, Y, Gao, Y, Peters, P.J, Ravelli, R.B.G.
Deposit date:2021-04-10
Release date:2021-05-19
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (2.1 Å)
Cite:Mycobacterium tuberculosis ferritin: a suitable workhorse protein for cryo-EM development.
Acta Crystallogr D Struct Biol, 77, 2021
5Y8Y
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BU of 5y8y by Molmil
Crystal Structure Analysis of the BRD4
Descriptor: 1,2-ETHANEDIOL, 5-bromanyl-2-methoxy-N-(6-methoxy-3-methyl-1,2-benzoxazol-5-yl)benzenesulfonamide, Bromodomain-containing protein 4, ...
Authors:Xu, Y, Zhang, Y, Song, M, Wang, C.
Deposit date:2017-08-21
Release date:2018-06-13
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC)
J. Med. Chem., 61, 2018
4EAY
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BU of 4eay by Molmil
Crystal structures of mannonate dehydratase from Escherichia coli strain K12 complexed with D-mannonate
Descriptor: CHLORIDE ION, D-MANNONIC ACID, MANGANESE (II) ION, ...
Authors:Qiu, X, Zhu, Y, Yuan, Y, Zhang, Y, Liu, H, Gao, Y, Teng, M, Niu, L.
Deposit date:2012-03-23
Release date:2013-03-27
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural insights into decreased enzymatic activity induced by an insert sequence in mannonate dehydratase from Gram negative bacterium.
J.Struct.Biol., 180, 2012
8J6R
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BU of 8j6r by Molmil
Cryo-EM structure of the MK-6892-bound human HCAR2-Gi1 complex
Descriptor: 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Mao, C, Gao, M, Zang, S, Zhu, Y, Ma, X, Zhang, Y.
Deposit date:2023-04-26
Release date:2023-12-06
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:Orthosteric and allosteric modulation of human HCAR2 signaling complex.
Nat Commun, 14, 2023
8J6P
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BU of 8j6p by Molmil
Cryo-EM structure of the MK-6892-bound human HCAR2-Gi1 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 7-methyl-N-[(2R)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide, CHOLESTEROL, ...
Authors:Mao, C, Gao, M, Zang, S, Zhu, Y, Ma, X, Zhang, Y.
Deposit date:2023-04-26
Release date:2023-12-06
Method:ELECTRON MICROSCOPY (2.55 Å)
Cite:Orthosteric and allosteric modulation of human HCAR2 signaling complex.
Nat Commun, 14, 2023
8J6Q
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BU of 8j6q by Molmil
Cryo-EM structure of the 3-HB and compound 9n-bound human HCAR2-Gi1 complex
Descriptor: (3R)-3-hydroxybutanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 7-methyl-N-[(2R)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide, ...
Authors:Mao, C, Gao, M, Zang, S, Zhu, Y, Ma, X, Zhang, Y.
Deposit date:2023-04-26
Release date:2023-12-06
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Orthosteric and allosteric modulation of human HCAR2 signaling complex.
Nat Commun, 14, 2023
3L5T
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BU of 3l5t by Molmil
Crystal structure of macrophage migration inhibitory factor (MIF) with thiophenepiperazinylquinolinone inhibitor at 1.86A resolution
Descriptor: 1-methyl-2-oxo-4-[4-(thiophen-2-ylcarbonyl)piperazin-1-yl]-1,2-dihydroquinoline-3-carbonitrile, Macrophage migration inhibitory factor, SULFATE ION
Authors:McLean, L, Zhang, Y.
Deposit date:2009-12-22
Release date:2010-03-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site.
Bioorg.Med.Chem.Lett., 20, 2010
6DJ2
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BU of 6dj2 by Molmil
HIV-1 protease with single mutation L76V in complex with Lopinavir
Descriptor: CHLORIDE ION, HIV-1 protease, N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE, ...
Authors:Wang, Y.-F, Wong-Sam, A.E, Zhang, Y, Weber, I.T.
Deposit date:2018-05-24
Release date:2018-10-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Drug Resistance Mutation L76V Alters Nonpolar Interactions at the Flap-Core Interface of HIV-1 Protease.
ACS Omega, 3, 2018
3L5R
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BU of 3l5r by Molmil
Crystal structure of macrophage migration inhibitory factor (MIF) with phenylchromenone inhibitor at 1.94A resolution
Descriptor: 3-(3,4-dihydroxyphenyl)-7-hydroxy-4H-chromen-4-one, GLYCEROL, Macrophage migration inhibitory factor, ...
Authors:McLean, L, Zhang, Y.
Deposit date:2009-12-22
Release date:2010-03-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site.
Bioorg.Med.Chem.Lett., 20, 2010
3L5U
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BU of 3l5u by Molmil
Crystal structure of macrophage migration inhibitory factor (MIF) with benzothiazole inhibitor at 1.90A resolution
Descriptor: 6-HYDROXY-1,3-BENZOTHIAZOLE-2-SULFONAMIDE, Macrophage migration inhibitory factor, SULFATE ION
Authors:McLean, L, Zhang, Y.
Deposit date:2009-12-22
Release date:2010-03-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site.
Bioorg.Med.Chem.Lett., 20, 2010
6DDE
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BU of 6dde by Molmil
Mu Opioid Receptor-Gi Protein Complex
Descriptor: DAMGO, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Koehl, A, Hu, H, Maeda, S, Manglik, A, Zhang, Y, Kobilka, B.K, Skiniotis, G, Weis, W.I.
Deposit date:2018-05-10
Release date:2018-06-13
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the mu-opioid receptor-Giprotein complex.
Nature, 558, 2018
7V1U
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BU of 7v1u by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor ZJ12
Descriptor: 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ~{N}-(3-ethyl-6-methoxy-1,2-benzoxazol-5-yl)-2-methoxy-benzenesulfonamide
Authors:Zhang, M, Wang, C, Zhang, C, Zhang, Y, Xu, Y.
Deposit date:2021-08-06
Release date:2022-08-10
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Design, synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl) sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia.
Acta Pharmacol.Sin., 43, 2022
7V2J
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BU of 7v2j by Molmil
Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor 33
Descriptor: Bromodomain-containing protein 4, ~{N}-(3-ethyl-6-methoxy-1,2-benzoxazol-5-yl)-4-methoxy-benzenesulfonamide
Authors:Zhang, M, Wang, C, Zhang, C, Zhang, Y, Xu, Y.
Deposit date:2021-08-09
Release date:2022-08-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Design, synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl) sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia.
Acta Pharmacol.Sin., 43, 2022

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