2I30
 
 | | Human serum albumin complexed with myristate and salicylic acid | | Descriptor: | 2-HYDROXYBENZOIC ACID, MYRISTIC ACID, Serum albumin | | Authors: | Yang, F, Bian, C, Zhu, L, Zhao, G, Huang, Z, Huang, M. | | Deposit date: | 2006-08-17 | | Release date: | 2006-12-12 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Effect of human serum albumin on drug metabolism: Structural evidence of esterase activity of human serum albumin
J.Struct.Biol., 157, 2007
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2I2Z
 | | Human serum albumin complexed with myristate and aspirin | | Descriptor: | 2-HYDROXYBENZOIC ACID, MYRISTIC ACID, Serum albumin | | Authors: | Yang, F, Bian, C, Zhu, L, Zhao, G, Huang, Z, Huang, M. | | Deposit date: | 2006-08-17 | | Release date: | 2006-12-12 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Effect of human serum albumin on drug metabolism: Structural evidence of esterase activity of human serum albumin
J.Struct.Biol., 157, 2007
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3K18
 | | Tellurium modified DNA-8mer | | Descriptor: | 5'-D(*GP*(UMS)P*GP*(TTI)P*AP*CP*AP*C)-3' | | Authors: | Sheng, J, Hassan, A.E.A, Zhang, W, Huang, Z. | | Deposit date: | 2009-09-25 | | Release date: | 2010-10-06 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Synthesis and Structure Study of Oligonucleotides Derivatized with Tellurium Functionality
To be Published
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3S49
 | | RNA crystal structure with 2-Se-uridine modification | | Descriptor: | POTASSIUM ION, RNA (5'-R(*GP*UP*AP*UP*AP*(RUS)P*AP*C)-3') | | Authors: | Sheng, J, Gan, J, Sun, H, Hassan, A.E.H, Jiang, S, Huang, Z. | | Deposit date: | 2011-05-19 | | Release date: | 2011-06-29 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Higher Specificity of RNA Base Pairing with 2-Selenouridine
To be Published
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8ZYR
 | | Cryo-EM structure of BTN2A1-BTN3A1-BTN3A3 | | Descriptor: | (2E)-4-hydroxy-3-methylbut-2-en-1-yl trihydrogen diphosphate, Butyrophilin subfamily 2 member A1, Butyrophilin subfamily 3 member A1, ... | | Authors: | Gao, W, Zheng, J, Zhu, Y, Huang, Z. | | Deposit date: | 2024-06-18 | | Release date: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (4.07 Å) | | Cite: | Cryo-EM structure of BTN2A1-BTN3A1-BTN3A3
To Be Published
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5XBL
 | | Structure of nuclease in complex with associated protein | | Descriptor: | Associated protein, CRISPR-associated endonuclease Cas9/Csn1, RNA (98-MER) | | Authors: | Dong, D, Guo, M, Wang, S, Zhu, Y, Huang, Z. | | Deposit date: | 2017-03-20 | | Release date: | 2017-06-14 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (3.052 Å) | | Cite: | Structural basis of CRISPR-SpyCas9 inhibition by an anti-CRISPR protein
Nature, 546, 2017
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8B4G
 | | Structure of a fungal LPMO bound to ligands | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACRYLIC ACID, CHLORIDE ION, ... | | Authors: | Banerjee, S, Huang, Z, Brander, S, Johansen, K.S, Lo Leggio, L. | | Deposit date: | 2022-09-20 | | Release date: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.496 Å) | | Cite: | Structure of a fungal LPMO bound to ligands
To Be Published
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5TGP
 | | DNA 8mer containing two 2SeT modifications | | Descriptor: | DNA/RNA (5'-R(*G)-D(P*(2ST))-R(P*G)-D(P*(2ST))-R(P*AP*CP*AP*C)-3') | | Authors: | Zhang, W, Huang, Z. | | Deposit date: | 2016-09-28 | | Release date: | 2017-10-18 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | DNA 8mer containing two 2SeT modifications
To Be Published
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5TSL
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5TSK
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8IAZ
 | | Cryo-EM structure of the ISFba1 TnpB-reRNA-dsDNA complex | | Descriptor: | DNA (5'-D(P*AP*CP*AP*TP*GP*GP*AP*CP*CP*AP*TP*CP*AP*GP*CP*TP*CP*CP*TP*AP*AP*TP*GP*G)-3'), DNA (5'-D(P*CP*CP*AP*TP*TP*AP*GP*GP*AP*GP*CP*TP*GP*AP*TP*G)-3'), RNA (207-MER), ... | | Authors: | Yin, M, Zhou, F, Zhu, Y, Huang, Z. | | Deposit date: | 2023-02-09 | | Release date: | 2024-04-17 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Discovery and structural mechanism of DNA endonucleases guided by RAGATH-18-derived RNAs.
Cell Res., 34, 2024
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7FJD
 | | Cryo-EM structure of a membrane protein(WT) | | Descriptor: | CHOLESTEROL, T cell receptor alpha variable 12-3,Possible J 11 gene segment,T cell receptor alpha chain constant, T cell receptor beta variable 6-5,M1-specific T cell receptor beta chain,T cell receptor beta constant 2, ... | | Authors: | Chen, Y, Zhu, Y, Gao, W, Zhang, A, Guo, C, Huang, Z. | | Deposit date: | 2021-08-03 | | Release date: | 2022-07-27 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility.
Mol.Cell, 82, 2022
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7FJE
 | | Cryo-EM structure of a membrane protein(LL) | | Descriptor: | CHOLESTEROL, T cell receptor alpha variable 12-3,Possible J 11 gene segment,T cell receptor alpha chain constant, T cell receptor beta variable 6-5,M1-specific T cell receptor beta chain,T cell receptor beta constant 2, ... | | Authors: | Chen, Y, Zhu, Y, Gao, W, Zhang, A, Guo, C, Huang, Z. | | Deposit date: | 2021-08-03 | | Release date: | 2022-07-27 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility.
Mol.Cell, 82, 2022
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7FJF
 | | Cryo-EM structure of a membrane protein(CS) | | Descriptor: | CHOLEST-5-EN-3-YL HYDROGEN SULFATE, T cell receptor alpha variable 12-3,Possible J 11 gene segment,T cell receptor alpha chain constant, T cell receptor beta variable 6-5,M1-specific T cell receptor beta chain,T cell receptor beta constant 2, ... | | Authors: | Chen, Y, Zhu, Y, Gao, W, Zhang, A, Guo, C, Huang, Z. | | Deposit date: | 2021-08-03 | | Release date: | 2022-07-27 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility.
Mol.Cell, 82, 2022
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5KK5
 | | AsCpf1(E993A)-crRNA-DNA ternary complex | | Descriptor: | CRISPR-associated endonuclease Cpf1, DNA (28-MER), DNA (8-mer), ... | | Authors: | Gao, P, Yang, H, Rajashankar, K.R, Huang, Z, Patel, D.J. | | Deposit date: | 2016-06-21 | | Release date: | 2016-08-10 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (3.289 Å) | | Cite: | Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition.
Cell Res., 26, 2016
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3WVJ
 | | The crystal structure of native glycosidic hydrolase | | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Beta-glucanase | | Authors: | Chen, C.C, Huang, J.W, Zhao, P, Ko, T.P, Huang, C.H, Chan, H.C, Huang, Z, Liu, W, Cheng, Y.S, Liu, J.R, Guo, R.T. | | Deposit date: | 2014-05-22 | | Release date: | 2015-06-24 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural analyses and yeast production of the beta-1,3-1,4-glucanase catalytic module encoded by the licB gene of Clostridium thermocellum.
Enzyme.Microb.Technol., 71, 2015
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2O8W
 | | Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors | | Descriptor: | 1-phenylguanidine, SULFATE ION, TETRAETHYLENE GLYCOL, ... | | Authors: | Zhao, G, Yuan, C, Jiang, L, Huang, Z, Huang, M. | | Deposit date: | 2006-12-12 | | Release date: | 2007-12-25 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors
To be Published
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2O8T
 | | Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q) in complex with Inhibitors | | Descriptor: | DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, SULFATE ION, ... | | Authors: | Zhao, G, Yuan, C, Jiang, L, Huang, Z, Huang, M. | | Deposit date: | 2006-12-12 | | Release date: | 2007-12-25 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors
To be Published
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2NWN
 | | New Pharmacophore for Serine Protease Inhibition Revealed by Crystal Structure of Human Urokinase-type Plasminogen Activator Complexed with a Cyclic Peptidyl Inhibitor, upain-1 | | Descriptor: | Plasminogen activator, urokinase, upain-1 | | Authors: | Zhao, G, Yuan, C, Wind, T, Andreasen, P.A, Huang, Z, Huang, M, Structural Genomics Consortium (SGC) | | Deposit date: | 2006-11-16 | | Release date: | 2007-10-16 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structural basis of specificity of a peptidyl urokinase inhibitor, upain-1
J.Struct.Biol., 160, 2007
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2O8U
 | | Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors | | Descriptor: | BENZAMIDINE, DI(HYDROXYETHYL)ETHER, SULFATE ION, ... | | Authors: | Zhao, G, Yuan, C, Jiang, L, Huang, Z, Huang, M. | | Deposit date: | 2006-12-12 | | Release date: | 2007-12-25 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors
To be Published
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6X5D
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9IS7
 | | Paracandidimonas lactea CP group II intron 2S state | | Descriptor: | MAGNESIUM ION, POTASSIUM ION, RNA (153-MER), ... | | Authors: | Wang, L, Xie, J.H, Zhang, C, Zou, J, Huang, Z, Shang, S, Chen, X, Yang, Y, Liu, J, Dong, H, Huang, D, Su, Z. | | Deposit date: | 2024-07-17 | | Release date: | 2025-02-12 | | Last modified: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (2.87 Å) | | Cite: | Structural basis of circularly permuted group II intron self-splicing.
Nat.Struct.Mol.Biol., 32, 2025
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1MA8
 | | A-DNA decamer GCGTA(UMS)ACGC with incorporated 2'-methylseleno-uridine | | Descriptor: | 5'-D(*GP*CP*GP*TP*AP*UMSP*AP*CP*GP*C)-3' | | Authors: | Teplova, M, Wilds, C.J, Wawrzak, Z, Tereshko, V, Du, Q, Carrasco, N, Huang, Z, Egli, M. | | Deposit date: | 2002-08-01 | | Release date: | 2002-12-11 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Covalent incorporation of selenium into oligonucleotides for X-ray crystal structure determination via MAD: proof of principle
BIOCHIMIE, 84, 2002
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9J5J
 | | Cryo-EM structure of BTN2A1-BTN3A1-BTN3A2 in complex with gdTCR | | Descriptor: | (2E)-4-hydroxy-3-methylbut-2-en-1-yl trihydrogen diphosphate, Butyrophilin subfamily 2 member A1, Butyrophilin subfamily 3 member A1, ... | | Authors: | Zhu, Y, Gao, W, Huang, Z. | | Deposit date: | 2024-08-12 | | Release date: | 2025-05-21 | | Method: | ELECTRON MICROSCOPY (4.05 Å) | | Cite: | Phosphoantigen-induced inside-out stabilization of butyrophilin receptor complexes drives dimerization-dependent gamma delta TCR activation.
Immunity, 2025
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9J5M
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