8J3R
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![BU of 8j3r by Molmil](/molmil-images/mine/8j3r) | Cryo-EM structure of the AsCas12f-HKRA-sgRNAS3-5v7-target DNA | Descriptor: | DNA (37-MER), DNA (38-MER), MAGNESIUM ION, ... | Authors: | Hino, T, Omura, N.S, Nakagawa, R, Togashi, T, Takeda, N.S, Hiramoto, T, Tasaka, S, Hirano, H, Tokuyama, T, Uosaki, H, Ishiguro, H, Yamano, H, Ozaki, Y, Motooka, D, Mori, H, Kirita, Y, Kise, Y, Itoh, Y, Matoba, S, Aburatani, H, Yachie, N, Siksnys, V, Ohmori, T, Hoshino, A, Nureki, O. | Deposit date: | 2023-04-18 | Release date: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | Minimal and most efficient genome editing Cas enzyme To Be Published
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8H1J
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![BU of 8h1j by Molmil](/molmil-images/mine/8h1j) | Cryo-EM structure of the TnpB-omegaRNA-target DNA ternary complex | Descriptor: | Non-target strand, RNA-guided DNA endonuclease TnpB, Target strand, ... | Authors: | Nakagawa, R, Hirano, H, Omura, S, Nureki, O. | Deposit date: | 2022-10-03 | Release date: | 2023-04-12 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM structure of the transposon-associated TnpB enzyme. Nature, 616, 2023
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4ZJ7
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![BU of 4zj7 by Molmil](/molmil-images/mine/4zj7) | |
7F8J
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![BU of 7f8j by Molmil](/molmil-images/mine/7f8j) | Cryo-EM structure of human pannexin-1 in a nanodisc | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Pannexin-1 | Authors: | Kuzuya, M, Hirano, H, Hayashida, K, Watanabe, M, Kobayashi, K, Tani, K, Fujiyoshi, Y, Oshima, A. | Deposit date: | 2021-07-02 | Release date: | 2022-01-26 | Last modified: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids. Sci.Signal., 15, 2022
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7F8O
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![BU of 7f8o by Molmil](/molmil-images/mine/7f8o) | Cryo-EM structure of the C-terminal deletion mutant of human PANX1 in a nanodisc | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Pannexin-1 | Authors: | Kuzuya, M, Hirano, H, Hayashida, K, Watanabe, M, Kobayashi, K, Tani, K, Fujiyoshi, Y, Oshima, A. | Deposit date: | 2021-07-02 | Release date: | 2022-01-26 | Last modified: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids. Sci.Signal., 15, 2022
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7F8N
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![BU of 7f8n by Molmil](/molmil-images/mine/7f8n) | Human pannexin-1 showing a conformational change in the N-terminal domain and blocked pore | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Pannexin-1 | Authors: | Kuzuya, M, Hirano, H, Hayashida, K, Watanabe, M, Kobayashi, K, Tani, K, Fujiyoshi, Y, Oshima, A. | Deposit date: | 2021-07-02 | Release date: | 2022-01-26 | Last modified: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids. Sci.Signal., 15, 2022
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7WSV
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![BU of 7wsv by Molmil](/molmil-images/mine/7wsv) | Cryo-EM structure of the N-terminal deletion mutant of human pannexin-1 in a nanodisc | Descriptor: | Pannexin-1 | Authors: | Kuzuya, M, Hirano, H, Hayashida, K, Watanabe, M, Kobayashi, K, Tani, K, Fujiyoshi, Y, Oshima, A. | Deposit date: | 2022-02-01 | Release date: | 2022-02-16 | Last modified: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids. Sci.Signal., 15, 2022
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5X2H
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![BU of 5x2h by Molmil](/molmil-images/mine/5x2h) | Crystal structure of Campylobacter jejuni Cas9 in complex with sgRNA and target DNA (AGAAACA PAM) | Descriptor: | 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cas9, Non-target DNA strand, ... | Authors: | Yamada, M, Watanabe, Y, Hirano, H, Nakane, T, Ishitani, R, Nishimasu, H, Nureki, O. | Deposit date: | 2017-01-31 | Release date: | 2017-03-29 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems Mol. Cell, 65, 2017
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5X2G
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![BU of 5x2g by Molmil](/molmil-images/mine/5x2g) | Crystal structure of Campylobacter jejuni Cas9 in complex with sgRNA and target DNA (AGAAACC PAM) | Descriptor: | 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cas9, Non-target DNA strand, ... | Authors: | Yamada, M, Watanabe, Y, Hirano, H, Nakane, T, Ishitani, R, Nishimasu, H, Nureki, O. | Deposit date: | 2017-01-31 | Release date: | 2017-03-29 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems Mol. Cell, 65, 2017
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3AUP
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![BU of 3aup by Molmil](/molmil-images/mine/3aup) | Crystal structure of Basic 7S globulin from soybean | Descriptor: | Basic 7S globulin | Authors: | Yoshizawa, T, Shimizu, T, Taichi, M, Nishiuchi, Y, Yamabe, M, Shichijo, N, Unzai, S, Hirano, H, Sato, M, Hashimoto, H. | Deposit date: | 2011-02-14 | Release date: | 2011-04-27 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Crystal structure of basic 7S globulin, a xyloglucan-specific endo-beta-1,4-glucanase inhibitor protein-like protein from soybean lacking inhibitory activity against endo-beta-glucanase Febs J., 278, 2011
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8HIO
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![BU of 8hio by Molmil](/molmil-images/mine/8hio) | Cryo-EM structure of the Cas12m2-crRNA binary complex | Descriptor: | Cas12m2, MAGNESIUM ION, RNA (56-MER), ... | Authors: | Omura, N.S, Nakagawa, R, Wu, Y.W, Sudfeld, C, Warren, V.R, Hirano, H, Kusakizako, T, Kise, Y, Lebbink, H.G.J, Itoh, Y, Oost, V.D.J, Nureki, O. | Deposit date: | 2022-11-21 | Release date: | 2023-04-12 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (3.73 Å) | Cite: | Mechanistic and evolutionary insights into a type V-M CRISPR-Cas effector enzyme. Nat.Struct.Mol.Biol., 30, 2023
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8HHM
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![BU of 8hhm by Molmil](/molmil-images/mine/8hhm) | Cryo-EM structure of the Cas12m2-crRNA-target DNA ternary complex intermediate state | Descriptor: | Cas12m2, DNA (36-MER), MAGNESIUM ION, ... | Authors: | Omura, N.S, Nakagawa, R, Wu, Y.W, Sudfeld, C, Warren, V.R, Hirano, H, Kusakizako, T, Kise, Y, Lebbink, H.G.J, Itoh, Y, Oost, V.D.J, Nureki, O. | Deposit date: | 2022-11-16 | Release date: | 2023-04-12 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | Mechanistic and evolutionary insights into a type V-M CRISPR-Cas effector enzyme. Nat.Struct.Mol.Biol., 30, 2023
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8HHL
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![BU of 8hhl by Molmil](/molmil-images/mine/8hhl) | Cryo-EM structure of the Cas12m2-crRNA-target DNA full R-loop complex | Descriptor: | Cas12m2, MAGNESIUM ION, NTS (36-MER), ... | Authors: | Omura, N.S, Nakagawa, R, Wu, Y.W, Sudfeld, C, Warren, V.R, Hirano, H, Kusakizako, T, Kise, Y, Lebbink, H.G.J, Itoh, Y, Oost, V.D.J, Nureki, O. | Deposit date: | 2022-11-16 | Release date: | 2023-04-12 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (2.87 Å) | Cite: | Mechanistic and evolutionary insights into a type V-M CRISPR-Cas effector enzyme. Nat.Struct.Mol.Biol., 30, 2023
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3VLA
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![BU of 3vla by Molmil](/molmil-images/mine/3vla) | Crystal structure of edgp | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, EDGP | Authors: | Yoshizawa, T, Shimizu, T, Hirano, H, Sato, M, Hashimoto, H. | Deposit date: | 2011-11-30 | Release date: | 2012-04-18 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (0.95 Å) | Cite: | Structural basis for inhibition of xyloglucan-specific endo-beta-1,4-glucanase (XEG) by XEG-protein inhibitor J.Biol.Chem., 287, 2012
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3VLB
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![BU of 3vlb by Molmil](/molmil-images/mine/3vlb) | Crystal structure of xeg-edgp | Descriptor: | EDGP, Xyloglucan-specific endo-beta-1,4-glucanase A | Authors: | Yoshizawa, T, Shimizu, T, Hirano, H, Sato, M, Hashimoto, H. | Deposit date: | 2011-11-30 | Release date: | 2012-04-18 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis for inhibition of xyloglucan-specific endo-beta-1,4-glucanase (XEG) by XEG-protein inhibitor J.Biol.Chem., 287, 2012
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3VL8
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![BU of 3vl8 by Molmil](/molmil-images/mine/3vl8) | Crystal structure of XEG | Descriptor: | SULFATE ION, Xyloglucan-specific endo-beta-1,4-glucanase A | Authors: | Yoshizawa, T, Shimizu, T, Hirano, H, Sato, M, Hashimoto, H. | Deposit date: | 2011-11-30 | Release date: | 2012-04-18 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for inhibition of xyloglucan-specific endo-beta-1,4-glucanase (XEG) by XEG-protein inhibitor J.Biol.Chem., 287, 2012
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3VL9
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![BU of 3vl9 by Molmil](/molmil-images/mine/3vl9) | Crystal structure of xeg-xyloglucan | Descriptor: | Xyloglucan-specific endo-beta-1,4-glucanase A, beta-D-glucopyranose-(1-4)-[alpha-D-xylopyranose-(1-6)]beta-D-glucopyranose-(1-4)-[alpha-D-xylopyranose-(1-6)]beta-D-glucopyranose-(1-4)-beta-D-glucopyranose, beta-D-glucopyranose-(1-4)-[alpha-D-xylopyranose-(1-6)]beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose | Authors: | Yoshizawa, T, Shimizu, T, Hirano, H, Sato, M, Hashimoto, H. | Deposit date: | 2011-11-30 | Release date: | 2012-04-18 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Structural basis for inhibition of xyloglucan-specific endo-beta-1,4-glucanase (XEG) by XEG-protein inhibitor J.Biol.Chem., 287, 2012
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5WUN
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![BU of 5wun by Molmil](/molmil-images/mine/5wun) | |
5WUM
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![BU of 5wum by Molmil](/molmil-images/mine/5wum) | |
5H2V
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![BU of 5h2v by Molmil](/molmil-images/mine/5h2v) | |
6AI6
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![BU of 6ai6 by Molmil](/molmil-images/mine/6ai6) | Crystal structure of SpCas9-NG | Descriptor: | 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cas9/Csn1, DNA (28-MER), ... | Authors: | Nishimasu, H, Hirano, S, Ishitani, R, Nureki, O. | Deposit date: | 2018-08-21 | Release date: | 2018-10-31 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Engineered CRISPR-Cas9 nuclease with expanded targeting space Science, 361, 2018
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5JHF
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![BU of 5jhf by Molmil](/molmil-images/mine/5jhf) | |
4P1W
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![BU of 4p1w by Molmil](/molmil-images/mine/4p1w) | |
4P1N
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![BU of 4p1n by Molmil](/molmil-images/mine/4p1n) | Crystal structure of Atg1-Atg13 complex | Descriptor: | Atg1 tMIT, Atg13 MIM | Authors: | Fujioka, Y, Noda, N.N. | Deposit date: | 2014-02-27 | Release date: | 2014-05-07 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis of starvation-induced assembly of the autophagy initiation complex. Nat.Struct.Mol.Biol., 21, 2014
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1VBH
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![BU of 1vbh by Molmil](/molmil-images/mine/1vbh) | Pyruvate Phosphate Dikinase with bound Mg-PEP from Maize | Descriptor: | MAGNESIUM ION, PHOSPHOENOLPYRUVATE, SULFATE ION, ... | Authors: | Nakanishi, T, Nakatsu, T, Matsuoka, M, Sakata, K, Kato, H, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2004-02-26 | Release date: | 2005-03-08 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structures of pyruvate phosphate dikinase from maize revealed an alternative conformation in the swiveling-domain motion Biochemistry, 44, 2005
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