7WSV

Cryo-EM structure of the N-terminal deletion mutant of human pannexin-1 in a nanodisc

Replaces:  7F8Q

Summary for 7WSV

• Entry DOI: 10.2210/pdb7wsv/pdb
• EMDB information: 32768
• Descriptor: Pannexin-1 (1 entity in total)
• Functional Keywords: atp release channel, vertebrate innexin homolog, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 7
• Total formula weight: 321688.07

Authors

Kuzuya, M.,Hirano, H.,Hayashida, K.,Watanabe, M.,Kobayashi, K.,Tani, K.,Fujiyoshi, Y.,Oshima, A. (deposition date: 2022-02-01, release date: 2022-02-16, Last modification date: 2022-02-23)

• Primary citation: Kuzuya, M.,Hirano, H.,Hayashida, K.,Watanabe, M.,Kobayashi, K.,Terada, T.,Mahmood, M.I.,Tama, F.,Tani, K.,Fujiyoshi, Y.,Oshima, A.; Structures of human pannexin-1 in nanodiscs reveal gating mediated by dynamic movement of the N terminus and phospholipids.; Sci.Signal., 15:eabg6941-eabg6941, 2022; PubMed: 35133866; DOI: 10.1126/scisignal.abg6941

Experimental method

ELECTRON MICROSCOPY (4.5 Å)