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1S2Q
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BU of 1s2q by Molmil
Crystal structure of MAOB in complex with N-propargyl-1(R)-aminoindan (Rasagiline)
Descriptor: (1R)-N-(prop-2-en-1-yl)-2,3-dihydro-1H-inden-1-amine, Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Binda, C, Hubalek, F, Li, M, Herzig, Y, Sterling, J, Edmondson, D.E, Mattevi, A.
Deposit date:2004-01-09
Release date:2004-03-30
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Crystal Structures of Monoamine Oxidase B in Complex with Four Inhibitors of the N-Propargylaminoindan Class.
J.Med.Chem., 47, 2004
1S2Y
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BU of 1s2y by Molmil
Crystal structure of MAOB in complex with N-propargyl-1(S)-aminoindan
Descriptor: Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, N-PROPARGYL-1(S)-AMINOINDAN
Authors:Binda, C, Hubalek, F, Li, M, Herzig, Y, Sterling, J, Edmondson, D.E, Mattevi, A.
Deposit date:2004-01-12
Release date:2004-03-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Crystal Structures of Monoamine Oxidase B in Complex with Four Inhibitors of the N-Propargylaminoindan Class.
J.Med.Chem., 47, 2004
2V60
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BU of 2v60 by Molmil
Structure of human MAO B in complex with the selective inhibitor 7-(3- chlorobenzyloxy)-4-carboxaldehyde-coumarin
Descriptor: 7-[(3-CHLOROBENZYL)OXY]-2-OXO-2H-CHROMENE-4-CARBALDEHYDE, AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Binda, C, Wang, J, Pisani, L, Caccia, C, Carotti, A, Salvati, P, Edmondson, D.E, Mattevi, A.
Deposit date:2007-07-12
Release date:2007-10-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs.
J.Med.Chem., 50, 2007
2V61
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BU of 2v61 by Molmil
Structure of human MAO B in complex with the selective inhibitor 7-(3- chlorobenzyloxy)-4-(methylamino)methyl-coumarin
Descriptor: 7-[(3-CHLOROBENZYL)OXY]-4-[(METHYLAMINO)METHYL]-2H-CHROMEN-2-ONE, AMINE OXIDASE (FLAVIN-CONTAINING) B, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Binda, C, Wang, J, Pisani, L, Caccia, C, Carotti, A, Salvati, P, Edmondson, D.E, Mattevi, A.
Deposit date:2007-07-13
Release date:2007-10-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of Human Monoamine Oxidase B Complexes with Selective Noncovalent Inhibitors: Safinamide and Coumarin Analogs.
J.Med.Chem., 50, 2007
2XAF
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BU of 2xaf by Molmil
Crystal structure of LSD1-CoREST in complex with para-bromo-(+)-cis-2- phenylcyclopropyl-1-amine
Descriptor: 3-(4-BROMOPHENYL)PROPANAMIDE, FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, ...
Authors:Binda, C, Valente, S, Romanenghi, M, Pilotto, S, Cirilli, R, Karytinos, A, Ciossani, G, Botrugno, O.A, Forneris, F, Tardugno, M, Edmondson, D.E, Minucci, S, Mattevi, A, Mai, A.
Deposit date:2010-03-31
Release date:2010-05-05
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2.
J.Am.Chem.Soc., 132, 2010
2XAH
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BU of 2xah by Molmil
Crystal structure of LSD1-CoREST in complex with (+)-trans-2- phenylcyclopropyl-1-amine
Descriptor: 3-PHENYLPROPANAL, FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, ...
Authors:Binda, C, Valente, S, Romanenghi, M, Pilotto, S, Cirilli, R, Karytinos, A, Ciossani, G, Botrugno, O.A, Forneris, F, Tardugno, M, Edmondson, D.E, Minucci, S, Mattevi, A, Mai, A.
Deposit date:2010-03-31
Release date:2010-05-05
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2.
J.Am.Chem.Soc., 132, 2010
2XAG
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BU of 2xag by Molmil
Crystal structure of LSD1-CoREST in complex with para-bromo-(-)-trans- 2-phenylcyclopropyl-1-amine
Descriptor: 3-(4-BROMOPHENYL)PROPANAMIDE, FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, ...
Authors:Binda, C, Valente, S, Romanenghi, M, Pilotto, S, Cirilli, R, Karytinos, A, Ciossani, G, Botrugno, O.A, Forneris, F, Tardugno, M, Edmondson, D.E, Minucci, S, Mattevi, A, Mai, A.
Deposit date:2010-03-31
Release date:2010-05-05
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2.
J.Am.Chem.Soc., 132, 2010
2XAJ
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BU of 2xaj by Molmil
Crystal structure of LSD1-CoREST in complex with (-)-trans-2- phenylcyclopropyl-1-amine
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, PHENYLETHYLENECARBOXYLIC ACID, ...
Authors:Binda, C, Valente, S, Romanenghi, M, Pilotto, S, Cirilli, R, Karytinos, A, Ciossani, G, Botrugno, O.A, Forneris, F, Tardugno, M, Edmondson, D.E, Minucci, S, Mattevi, A, Mai, A.
Deposit date:2010-03-31
Release date:2010-05-05
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2.
J.Am.Chem.Soc., 132, 2010
2XAS
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BU of 2xas by Molmil
Crystal structure of LSD1-CoREST in complex with a tranylcypromine derivative (MC2580, 14e)
Descriptor: 3-[4-({N-[(BENZYLOXY)CARBONYL]-L-PHENYLALANYL}AMINO)PHENYL]PROPANOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, ...
Authors:Binda, C, Valente, S, Romanenghi, M, Pilotto, S, Cirilli, R, Karytinos, A, Ciossani, G, Botrugno, O.A, Forneris, F, Tardugno, M, Edmondson, D.E, Minucci, S, Mattevi, A, Mai, A.
Deposit date:2010-03-31
Release date:2010-05-05
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2.
J.Am.Chem.Soc., 132, 2010
2VRL
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BU of 2vrl by Molmil
Structure of human MAO B in complex with benzylhydrazine
Descriptor: AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, TOLUENE
Authors:Binda, C, Wang, J, Li, M, Hubalek, F, Mattevi, A, Edmondson, D.E.
Deposit date:2008-04-09
Release date:2008-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and Mechanistic Studies of Arylalkylhydrazine Inhibition of Human Monoamine Oxidases a and B
Biochemistry, 47, 2008
2VRM
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BU of 2vrm by Molmil
Structure of human MAO B in complex with phenyethylhydrazine
Descriptor: AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, PHENYLETHANE
Authors:Binda, C, Wang, J, Li, M, Hubalek, F, Mattevi, A, Edmondson, D.E.
Deposit date:2008-04-09
Release date:2008-04-22
Last modified:2014-01-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and Mechanistic Studies of Arylalkylhydrazine Inhibition of Human Monoamine Oxidases a and B
Biochemistry, 47, 2008
2XAQ
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BU of 2xaq by Molmil
Crystal structure of LSD1-CoREST in complex with a tranylcypromine derivative (MC2584, 13b)
Descriptor: 3-{4-[(PHENYLCARBONYL)AMINO]PHENYL}PROPANOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, ...
Authors:Binda, C, Valente, S, Romanenghi, M, Pilotto, S, Cirilli, R, Karytinos, A, Ciossani, G, Botrugno, O.A, Forneris, F, Tardugno, M, Edmondson, D.E, Minucci, S, Mattevi, A, Mai, A.
Deposit date:2010-03-31
Release date:2010-05-05
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2.
J.Am.Chem.Soc., 132, 2010
7ZW3
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BU of 7zw3 by Molmil
Crystal Structure of human MAO B in complex with (Z)-N-benzyl-1-(8-hydroxyquinolin-2-yl)methanimine oxide (inhibitor 19)
Descriptor: 1-(8-oxidanylquinolin-2-yl)-N-(phenylmethyl)methanimine oxide, Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Binda, C, Gottinger, A.
Deposit date:2022-05-18
Release date:2023-03-29
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases.
Acta Pharm Sin B, 13, 2023
5MRL
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BU of 5mrl by Molmil
Crystal structure of human monoamine oxidase B (MAO B) in complex with N(Furan2ylmethyl)Nmethylprop2yn1amine (F2MPA)
Descriptor: (~{E})-~{N}-(furan-2-ylmethyl)-~{N}-methyl-prop-1-en-1-amine, Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Binda, C, De Deurwaerdere, P, Corne, R, Leone, C, Valeri, A, Valoti, M, Ramsay, R.R, Fall, Y, Marco-Contelles, J.
Deposit date:2016-12-23
Release date:2017-01-11
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Comparative Analysis of the Neurochemical Profile and MAO Inhibition Properties of N-(Furan-2-ylmethyl)-N-methylprop-2-yn-1-amine.
ACS Chem Neurosci, 8, 2017
2BK4
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BU of 2bk4 by Molmil
Human Monoamine Oxidase B: I199F mutant in complex with rasagiline
Descriptor: (1R)-N-(prop-2-en-1-yl)-2,3-dihydro-1H-inden-1-amine, AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Binda, C, Edmondson, D.E, Mattevi, A, Hubalek, F, Khalil, A, Li, M, Castagnoli, N.
Deposit date:2005-02-10
Release date:2005-02-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Demonstration of Isoleucine 199 as a Structural Determinant for the Selective Inhibition of Human Monoamine Oxidase B by Specific Reversible Inhibitors
J.Biol.Chem., 280, 2005
2BK3
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BU of 2bk3 by Molmil
Human Monoamine Oxidase B in complex with Farnesol
Descriptor: (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol, AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Binda, C, Edmondson, D.E, Mattevi, A.
Deposit date:2005-02-10
Release date:2005-02-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors.
J. Biol. Chem., 280, 2005
2BK5
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BU of 2bk5 by Molmil
Human Monoamine Oxidase B: I199F mutant in complex with isatin
Descriptor: AMINE OXIDASE [FLAVIN-CONTAINING] B, FLAVIN-ADENINE DINUCLEOTIDE, ISATIN
Authors:Binda, C, Edmondson, D.E, Mattevi, A, Hubalek, F, Khalil, A, Li, M, Castagnoli, N.
Deposit date:2005-02-10
Release date:2005-02-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Demonstration of Isoleucine 199 as a Structural Determinant for the Selective Inhibition of Human Monoamine Oxidase B by Specific Reversible Inhibitors.
J.Biol.Chem., 280, 2005
2BYB
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BU of 2byb by Molmil
Human Monoamine Oxidase B in complex with Deprenyl
Descriptor: AMINE OXIDASE [FLAVIN-CONTAINING] B, DEPRENYL, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Binda, C, De Colibus, L, Edmondson, D.E, Mattevi, A.
Deposit date:2005-07-29
Release date:2005-08-09
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Three-Dimensional Structure of Human Monoamine Oxidase a (Mao A): Relation to the Structures of Rat Mao a and Human Mao B
Proc.Natl.Acad.Sci.USA, 102, 2005
2XFU
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BU of 2xfu by Molmil
Human monoamine oxidase B with tranylcypromine
Descriptor: 3-PHENYLPROPANAL, Amine oxidase [flavin-containing] B, [[(2R,3S,4S)-5-[(4AS)-7,8-DIMETHYL-2,4-DIOXO-4A,5-DIHYDROBENZO[G]PTERIDIN-10-YL]-2,3,4-TRIHYDROXY-PENTOXY]-HYDROXY-PHOSPHORYL] [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL HYDROGEN PHOSPHATE
Authors:Binda, C, Li, M, Hubalek, F, Restelli, N, Edmondson, D.E, Mattevi, A.
Deposit date:2010-05-26
Release date:2010-06-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Potentiation of ligand binding through cooperative effects in monoamine oxidase B.
J. Biol. Chem., 285, 2010
8P84
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BU of 8p84 by Molmil
X-ray structure of Thermoanaerobacterales bacterium monoamine oxidase
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, MAGNESIUM ION, ...
Authors:Basile, L, Santema, L.L, Fraaije, M.W, Binda, C.
Deposit date:2023-05-31
Release date:2023-10-18
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Discovery and structural characterization of a thermostable bacterial monoamine oxidase.
Febs J., 291, 2024
5LXE
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BU of 5lxe by Molmil
F420-dependent glucose-6-phosphate dehydrogenase from Rhodococcus jostii RHA1
Descriptor: F420-dependent glucose-6-phosphate dehydrogenase 1, GLYCEROL, SULFATE ION
Authors:Nguyen, Q.-T, Trinco, G, Binda, C, Mattevi, A, Fraaije, M.W.
Deposit date:2016-09-20
Release date:2016-12-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Discovery and characterization of an F420-dependent glucose-6-phosphate dehydrogenase (Rh-FGD1) from Rhodococcus jostii RHA1.
Appl. Microbiol. Biotechnol., 101, 2017
5FXD
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BU of 5fxd by Molmil
Crystal structure of eugenol oxidase in complex with isoeugenol
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ISOEUGENOL, ...
Authors:Nguyen, Q.-T, de Gonzalo, G, Binda, C, Martinez, A.R, Mattevi, A, Fraaije, M.W.
Deposit date:2016-03-01
Release date:2016-07-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Biocatalytic Properties and Structural Analysis of Eugenol Oxidase from Rhodococcus Jostii Rha1: A Versatile Oxidative Biocatalyst.
Chembiochem, 17, 2016
6F97
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BU of 6f97 by Molmil
Crystal structure of the V465T mutant of 5-(Hydroxymethyl)furfural Oxidase (HMFO)
Descriptor: 5-(hydroxymethyl)furfural oxidase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Pickl, M, Swoboda, A, Romero, E, Winkler, C.K, Binda, C, Mattevi, A, Faber, K, Fraaije, M.W.
Deposit date:2017-12-14
Release date:2018-02-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Kinetic Resolution of sec-Thiols by Enantioselective Oxidation with Rationally Engineered 5-(Hydroxymethyl)furfural Oxidase.
Angew. Chem. Int. Ed. Engl., 57, 2018
4F4Q
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BU of 4f4q by Molmil
Crystal structure of M. smegmatis DprE1 in complex with FAD and covalently bound BTZ043
Descriptor: 8-(hydroxyamino)-2-[(2S)-2-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one, DprE1, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Neres, J, Pojer, F, Molteni, E, Chiarelli, L, Riccardi, G, Mattevi, A, Cole, S.T, Binda, C.
Deposit date:2012-05-11
Release date:2012-09-05
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.619 Å)
Cite:Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis.
Sci Transl Med, 4, 2012
7P4G
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BU of 7p4g by Molmil
Rabbit Muscle L-lactate dehydrogenase in complex with citrate
Descriptor: CITRIC ACID, L-lactate dehydrogenase A chain
Authors:Iacovino, L.G, Binda, C, Hochkoeppler, A.
Deposit date:2021-07-11
Release date:2022-05-18
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Allosteric transitions of rabbit skeletal muscle lactate dehydrogenase induced by pH-dependent dissociation of the tetrameric enzyme.
Biochimie, 199, 2022

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数据于2024-06-19公开中

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