7ZW3

Crystal Structure of human MAO B in complex with (Z)-N-benzyl-1-(8-hydroxyquinolin-2-yl)methanimine oxide (inhibitor 19)

This is a non-PDB format compatible entry.

Summary for 7ZW3

• Entry DOI: 10.2210/pdb7zw3/pdb
• Descriptor: Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, N-DODECYL-N,N-DIMETHYL-3-AMMONIO-1-PROPANESULFONATE, ... (5 entities in total)
• Functional Keywords: monoamine oxidase, alzheimer's disease, enzyme, drug, mitochondrial membrane, flavoprotein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 120476.28

Authors

Binda, C.,Gottinger, A. (deposition date: 2022-05-18, release date: 2023-03-29, Last modification date: 2024-02-07)

• Primary citation: Knez, D.,Diez-Iriepa, D.,Chioua, M.,Gottinger, A.,Denic, M.,Chantegreil, F.,Nachon, F.,Brazzolotto, X.,Skrzypczak-Wiercioch, A.,Meden, A.,Pislar, A.,Kos, J.,Zakelj, S.,Stojan, J.,Salat, K.,Serrano, J.,Fernandez, A.P.,Sanchez-Garcia, A.,Martinez-Murillo, R.,Binda, C.,Lopez-Munoz, F.,Gobec, S.,Marco-Contelles, J.; 8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases.; Acta Pharm Sin B, 13:2152-2175, 2023; PubMed: 37250172; DOI: 10.1016/j.apsb.2023.01.013

Experimental method

X-RAY DIFFRACTION (2 Å)