7ZW3

Crystal Structure of human MAO B in complex with (Z)-N-benzyl-1-(8-hydroxyquinolin-2-yl)methanimine oxide (inhibitor 19)

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0005515	molecular_function	protein binding
AAA	0005739	cellular_component	mitochondrion
AAA	0005740	cellular_component	mitochondrial envelope
AAA	0005741	cellular_component	mitochondrial outer membrane
AAA	0008131	molecular_function	primary amine oxidase activity
AAA	0009055	molecular_function	electron transfer activity
AAA	0009410	biological_process	response to xenobiotic stimulus
AAA	0009636	biological_process	response to toxic substance
AAA	0010044	biological_process	response to aluminum ion
AAA	0010269	biological_process	response to selenium ion
AAA	0014063	biological_process	negative regulation of serotonin secretion
AAA	0016491	molecular_function	oxidoreductase activity
AAA	0019607	biological_process	phenylethylamine catabolic process
AAA	0021762	biological_process	substantia nigra development
AAA	0030425	cellular_component	dendrite
AAA	0032496	biological_process	response to lipopolysaccharide
AAA	0042420	biological_process	dopamine catabolic process
AAA	0042802	molecular_function	identical protein binding
AAA	0043025	cellular_component	neuronal cell body
AAA	0045471	biological_process	response to ethanol
AAA	0045964	biological_process	positive regulation of dopamine metabolic process
AAA	0048545	biological_process	response to steroid hormone
AAA	0050660	molecular_function	flavin adenine dinucleotide binding
AAA	0050665	biological_process	hydrogen peroxide biosynthetic process
AAA	0051412	biological_process	response to corticosterone
AAA	0052595	molecular_function	aliphatic amine oxidase activity
AAA	0097621	molecular_function	monoamine oxidase activity
BBB	0005515	molecular_function	protein binding
BBB	0005739	cellular_component	mitochondrion
BBB	0005740	cellular_component	mitochondrial envelope
BBB	0005741	cellular_component	mitochondrial outer membrane
BBB	0008131	molecular_function	primary amine oxidase activity
BBB	0009055	molecular_function	electron transfer activity
BBB	0009410	biological_process	response to xenobiotic stimulus
BBB	0009636	biological_process	response to toxic substance
BBB	0010044	biological_process	response to aluminum ion
BBB	0010269	biological_process	response to selenium ion
BBB	0014063	biological_process	negative regulation of serotonin secretion
BBB	0016491	molecular_function	oxidoreductase activity
BBB	0019607	biological_process	phenylethylamine catabolic process
BBB	0021762	biological_process	substantia nigra development
BBB	0030425	cellular_component	dendrite
BBB	0032496	biological_process	response to lipopolysaccharide
BBB	0042420	biological_process	dopamine catabolic process
BBB	0042802	molecular_function	identical protein binding
BBB	0043025	cellular_component	neuronal cell body
BBB	0045471	biological_process	response to ethanol
BBB	0045964	biological_process	positive regulation of dopamine metabolic process
BBB	0048545	biological_process	response to steroid hormone
BBB	0050660	molecular_function	flavin adenine dinucleotide binding
BBB	0050665	biological_process	hydrogen peroxide biosynthetic process
BBB	0051412	biological_process	response to corticosterone
BBB	0052595	molecular_function	aliphatic amine oxidase activity
BBB	0097621	molecular_function	monoamine oxidase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	974
Details	TOPO_DOM: Cytoplasmic

Chain	Residue	Details
AAA	SER2-VAL489
BBB	SER2-VAL489

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site_id	SWS_FT_FI2
Number of Residues	52
Details	TRANSMEM: Helical; Anchor for type IV membrane protein

Chain	Residue	Details
AAA	PRO490-LEU516
BBB	PRO490-LEU516

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site_id	SWS_FT_FI3
Number of Residues	6
Details	TOPO_DOM: Mitochondrial intermembrane

Chain	Residue	Details
AAA	LEU517-VAL520
BBB	LEU517-VAL520

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	SITE: Important for catalytic activity

Chain	Residue	Details
AAA	CYS156
AAA	CYS365
AAA	HIS382
BBB	CYS156
BBB	CYS365
BBB	HIS382

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: N-acetylserine => ECO:0000269|PubMed:11049757

Chain	Residue	Details
AAA	SER2
BBB	SER2

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8BW75

Chain	Residue	Details
AAA	LYS52
BBB	LYS52

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: S-8alpha-FAD cysteine => ECO:0000269|PubMed:11753429, ECO:0000269|PubMed:12913124, ECO:0000269|PubMed:15027868, ECO:0000269|PubMed:15710600, ECO:0000269|PubMed:16366596, ECO:0007744|PDB:1GOS, ECO:0007744|PDB:1OJ9, ECO:0007744|PDB:1OJA, ECO:0007744|PDB:1OJC, ECO:0007744|PDB:1OJD, ECO:0007744|PDB:1S2Q, ECO:0007744|PDB:1S2Y, ECO:0007744|PDB:1S3B, ECO:0007744|PDB:1S3E, ECO:0007744|PDB:2BK3, ECO:0007744|PDB:2BK4, ECO:0007744|PDB:2BK5, ECO:0007744|PDB:2BYB, ECO:0007744|PDB:2C64, ECO:0007744|PDB:2C65, ECO:0007744|PDB:2C66, ECO:0007744|PDB:2C67, ECO:0007744|PDB:2C70, ECO:0007744|PDB:2C72, ECO:0007744|PDB:2C73, ECO:0007744|PDB:2C75, ECO:0007744|PDB:2C76, ECO:0007744|PDB:2V5Z, ECO:0007744|PDB:2V60, ECO:0007744|PDB:2V61, ECO:0007744|PDB:2VRL, ECO:0007744|PDB:2VRM, ECO:0007744|PDB:2VZ2, ECO:0007744|PDB:2XFN, ECO:0007744|PDB:2XFO, ECO:0007744|PDB:2XFP, ECO:0007744|PDB:2XFQ, ECO:0007744|PDB:3PO7, ECO:0007744|PDB:3ZYX, ECO:0007744|PDB:4A79, ECO:0007744|PDB:4A7A, ECO:0007744|PDB:4CRT, ECO:0007744|PDB:5MRL

Chain	Residue	Details
AAA	CYS397
BBB	CYS397

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