3Q6R
 
 | | Crystal Structure of P Domain from Norwalk Virus Strain Vietnam 026 in complex with disordered HBGA type Lex | | Descriptor: | 1,2-ETHANEDIOL, Capsid protein, IMIDAZOLE | | Authors: | Hansman, G.S, Biertumpfel, C, McLellan, J.S, Chen, L, Georgiev, I, Katayama, K, Kwong, P.D. | | Deposit date: | 2011-01-03 | | Release date: | 2011-05-11 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Crystal structures of GII.10 and GII.12 norovirus protruding domains in complex with histo-blood group antigens reveal details for a potential site of vulnerability.
J.Virol., 85, 2011
|
|
3R6J
 | | Crystal Structure of the Capsid P Domain from Norwalk Virus Strain Hiroshima/1999 | | Descriptor: | 1,2-ETHANEDIOL, VP1 protein | | Authors: | Hansman, G.S, Biertumpfel, C, McLellan, J.S, Georgiev, I, Chen, L, Zhou, T, Katayama, K, Kwong, P.D. | | Deposit date: | 2011-03-21 | | Release date: | 2011-05-11 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Crystal structures of GII.10 and GII.12 norovirus protruding domains in complex with histo-blood group antigens reveal details for a potential site of vulnerability.
J.Virol., 85, 2011
|
|
3R6K
 | | Crystal Structure of the Capsid P Domain from Norwalk Virus Strain Hiroshima/1999 in complex with HBGA type B (triglycan) | | Descriptor: | 1,2-ETHANEDIOL, VP1 protein, alpha-L-fucopyranose-(1-2)-[alpha-D-galactopyranose-(1-3)]beta-D-galactopyranose | | Authors: | Hansman, G.S, Biertumpfel, C, McLellan, J.S, Georgiev, I, Chen, L, Zhou, T, Katayama, K, Kwong, P.D. | | Deposit date: | 2011-03-21 | | Release date: | 2011-05-11 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Crystal structures of GII.10 and GII.12 norovirus protruding domains in complex with histo-blood group antigens reveal details for a potential site of vulnerability.
J.Virol., 85, 2011
|
|
6C9L
 | | MEF2B Apo Protein Structure | | Descriptor: | Myocyte-specific enhancer factor 2B | | Authors: | Lei, X, Chen, L. | | Deposit date: | 2018-01-26 | | Release date: | 2018-02-07 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal Structure of Apo MEF2B Reveals New Insights in DNA Binding and Cofactor Interaction.
Biochemistry, 57, 2018
|
|
6BZ1
 | | MEF2 Chimera D83V mutant/DNA complex | | Descriptor: | DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), DNA (5'-D(P*TP*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*TP*T)-3'), MEF2 CHIMERA | | Authors: | Lei, X, Chen, L. | | Deposit date: | 2017-12-21 | | Release date: | 2018-02-07 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.97 Å) | | Cite: | The Cancer Mutation D83V Induces an alpha-Helix to beta-Strand Conformation Switch in MEF2B.
J. Mol. Biol., 430, 2018
|
|
6BYY
 | | MEF2 CHIMERA/DNA Complex | | Descriptor: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, 3,3',3''-phosphanetriyltripropanoic acid, DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*GP*A)-3'), ... | | Authors: | Lei, X, Chen, L. | | Deposit date: | 2017-12-21 | | Release date: | 2018-01-31 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The Cancer Mutation D83V Induces an alpha-Helix to beta-Strand Conformation Switch in MEF2B.
J. Mol. Biol., 430, 2018
|
|
6NEB
 | | MYC Promoter G-Quadruplex with 1:6:1 loop length | | Descriptor: | DNA (27-MER) | | Authors: | Dickerhoff, J, Onel, B, Chen, L, Chen, Y, Yang, D. | | Deposit date: | 2018-12-17 | | Release date: | 2019-02-13 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Solution Structure of a MYC Promoter G-Quadruplex with 1:6:1 Loop Length.
Acs Omega, 4, 2019
|
|
4GX2
 | | GsuK channel bound to NAD | | Descriptor: | CALCIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PHOSPHATE ION, ... | | Authors: | Kong, C, Zeng, W, Ye, S, Chen, L, Sauer, D.B, Lam, Y, Derebe, M.G, Jiang, Y. | | Deposit date: | 2012-09-03 | | Release date: | 2012-12-26 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel.
elife, 1, 2012
|
|
4GX1
 | | Crystal structure of the GsuK bound to ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, PHOSPHATE ION, ... | | Authors: | Kong, C, Zeng, W, Ye, S, Chen, L, Sauer, D.B, Lam, Y, Derebe, M.G, Jiang, Y. | | Deposit date: | 2012-09-03 | | Release date: | 2012-12-26 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel.
elife, 1, 2012
|
|
5WUA
 | | Structure of a Pancreatic ATP-sensitive Potassium Channel | | Descriptor: | ATP-sensitive inward rectifier potassium channel 11,superfolder GFP, SUR1 | | Authors: | Li, N, Wu, J.-X, Chen, L, Gao, N. | | Deposit date: | 2016-12-16 | | Release date: | 2017-01-25 | | Method: | ELECTRON MICROSCOPY (5.6 Å) | | Cite: | Structure of a Pancreatic ATP-Sensitive Potassium Channel
Cell, 168, 2017
|
|
4GOB
 | | Low pH Crystal Structure of a reconstructed Kaede-type Red Fluorescent Protein, Least Evolved Ancestor (LEA) | | Descriptor: | Kaede-type Fluorescent Protein | | Authors: | Kim, H, Grunkemeyer, T.J, Chen, L, Fromme, R, Wachter, R.M. | | Deposit date: | 2012-08-19 | | Release date: | 2013-07-31 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.53 Å) | | Cite: | Acid-base catalysis and crystal structures of a least evolved ancestral GFP-like protein undergoing green-to-red photoconversion.
Biochemistry, 52, 2013
|
|
4GUL
 | | Study on structure and function relationships in human ferric Pirin | | Descriptor: | FE (III) ION, Pirin | | Authors: | Liu, F, Rehmani, I, Fu, R, Esaka, S, Chen, L, Serrano, V, Liu, A. | | Deposit date: | 2012-08-29 | | Release date: | 2013-05-29 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Pirin is an iron-dependent redox regulator of NF-kappa B.
Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
4GX0
 | | Crystal structure of the GsuK L97D mutant | | Descriptor: | CALCIUM ION, PHOSPHATE ION, POTASSIUM ION, ... | | Authors: | Kong, C, Zeng, W, Ye, S, Chen, L, Sauer, D.B, Lam, Y, Derebe, M.G, Jiang, Y. | | Deposit date: | 2012-09-03 | | Release date: | 2012-12-26 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.601 Å) | | Cite: | Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel.
elife, 1, 2012
|
|
4GX5
 | | GsuK Channel | | Descriptor: | CALCIUM ION, POTASSIUM ION, TrkA domain protein, ... | | Authors: | Kong, C, Zeng, W, Ye, S, Chen, L, Sauer, D.B, Lam, Y, Derebe, M.G, Jiang, Y. | | Deposit date: | 2012-09-03 | | Release date: | 2012-12-26 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (3.7 Å) | | Cite: | Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel.
elife, 1, 2012
|
|
4GVL
 | | Crystal Structure of the GsuK RCK domain | | Descriptor: | ADENOSINE MONOPHOSPHATE, CALCIUM ION, TrkA domain protein, ... | | Authors: | Kong, C, Zeng, W, Ye, S, Chen, L, Sauer, D.B, Lam, Y, Derebe, M.G, Jiang, Y. | | Deposit date: | 2012-08-30 | | Release date: | 2012-12-26 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel.
elife, 1, 2012
|
|
4HLT
 | | Crystal structure of ferric E32V Pirin | | Descriptor: | FE (II) ION, Pirin | | Authors: | Liu, F, Rehmani, I, Esaki, S, Fu, R, Chen, L, Serrano, V, Liu, A. | | Deposit date: | 2012-10-17 | | Release date: | 2013-05-29 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Pirin is an iron-dependent redox regulator of NF-kappa B.
Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
5X74
 | | The crystal Structure PDE delta in complex with compound (R, R)-1g | | Descriptor: | (2R)-2-(2-fluorophenyl)-3-[2-[4-[(2R)-2-(2-fluorophenyl)-4-oxidanylidene-1,2-dihydroquinazolin-3-yl]piperidin-1-yl]ethyl]-1,2-dihydroquinazolin-4-one, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | | Authors: | Jiang, Y, Zhuang, C, Chen, L, Wang, R, Wang, F, Sheng, C. | | Deposit date: | 2017-02-23 | | Release date: | 2017-10-04 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structural Biology-Inspired Discovery of Novel KRAS-PDE delta Inhibitors
J. Med. Chem., 60, 2017
|
|
4HVR
 | | X-ray crystal structure of salicylic acid bound 3-hydroxyanthranilate-3,4-dioxygenase from cupriavidus metallidurans | | Descriptor: | 2-HYDROXYBENZOIC ACID, 3-hydroxyanthranilate 3,4-dioxygenase, FE (III) ION | | Authors: | Liu, F, Chen, L, Liu, A. | | Deposit date: | 2012-11-06 | | Release date: | 2013-11-27 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | X-ray crystal structure of salicylic acid bound 3-hydroxyanthranilate-3,4-dioxygenase from cupriavidus metallidurans
To be Published
|
|
5X73
 | | The crystal Structure PDE delta in complex with R-p9 | | Descriptor: | (2R)-2-(2-fluorophenyl)-3-phenyl-1,2-dihydroquinazolin-4-one, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | | Authors: | Jiang, Y, Zhuang, C, Chen, L, Wang, R, Wang, F, Sheng, C. | | Deposit date: | 2017-02-23 | | Release date: | 2017-10-04 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural Biology-Inspired Discovery of Novel KRAS-PDE delta Inhibitors
J. Med. Chem., 60, 2017
|
|
4HQP
 | | Alpha7 nicotinic receptor chimera and its complex with Alpha bungarotoxin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-bungarotoxin isoform V31, ... | | Authors: | Li, S.X, Cheng, K, Gomoto, R, Bren, N, Huang, S, Sine, S, Chen, L. | | Deposit date: | 2012-10-25 | | Release date: | 2013-07-17 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.51 Å) | | Cite: | Structural principles for Alpha-neurotoxin binding to and selectivity among nicotinic receptors
To be Published
|
|
4HSL
 | | 2.00 angstrom x-ray crystal structure of substrate-bound E110A 3-hydroxyanthranilate-3,4-dioxygenase from Cupriavidus metallidurans | | Descriptor: | 3-HYDROXYANTHRANILIC ACID, 3-hydroxyanthranilate 3,4-dioxygenase, FE (II) ION | | Authors: | Liu, F, Chen, L, Liu, A. | | Deposit date: | 2012-10-30 | | Release date: | 2013-11-27 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | 2.00 angstrom x-ray crystal structure of substrate-bound
E110A 3-hydroxyanthranilate-3,4-dioxygenase from Cupriavidus
metallidurans
To be Published
|
|
5X72
 | | The crystal Structure PDE delta in complex with (rac)-p9 | | Descriptor: | (2R)-2-(2-fluorophenyl)-3-phenyl-1,2-dihydroquinazolin-4-one, (2S)-2-(2-fluorophenyl)-3-phenyl-1,2-dihydroquinazolin-4-one, Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | | Authors: | Jiang, Y, Zhuang, C, Chen, L, Wang, R, Wang, F, Sheng, C. | | Deposit date: | 2017-02-23 | | Release date: | 2017-10-04 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structural Biology-Inspired Discovery of Novel KRAS-PDE delta Inhibitors
J. Med. Chem., 60, 2017
|
|
8IOW
 | |
4K23
 | | Structure of anti-uPAR Fab ATN-658 | | Descriptor: | anti-uPAR antibody, heavy chain, light chain | | Authors: | Yuan, C, Huang, M, Chen, L. | | Deposit date: | 2013-04-08 | | Release date: | 2014-02-26 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Identification of a New Epitope in uPAR as a Target for the Cancer Therapeutic Monoclonal Antibody ATN-658, a Structural Homolog of the uPAR Binding Integrin CD11b ( alpha M)
Plos One, 9, 2014
|
|
4OU3
 | | Crystal structure of porcine aminopeptidase N complexed with CNGRCG tumor-homing peptide | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aminopeptidase N, ... | | Authors: | Liu, C, Yang, Y, Chen, L, Lin, Y.-L, Li, F. | | Deposit date: | 2014-02-14 | | Release date: | 2014-11-05 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | A Unified Mechanism for Aminopeptidase N-based Tumor Cell Motility and Tumor-homing Therapy.
J.Biol.Chem., 289, 2014
|
|
