5LGE
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![BU of 5lge by Molmil](/molmil-images/mine/5lge) | Crystal Structure of human IDH1 mutant (R132H) in complex with NADP+ and an Inhibitor related to BAY 1436032 | Descriptor: | 1,2-ETHANEDIOL, 2-[(4-propan-2-ylphenyl)amino]-1-[(1~{S},5~{S})-3,3,5-trimethylcyclohexyl]benzimidazole-5-carboxylic acid, ACETATE ION, ... | Authors: | Hillig, R.C, Hars, U, Korndoerfer, I.P. | Deposit date: | 2016-07-07 | Release date: | 2017-02-08 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo. Acta Neuropathol., 133, 2017
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8ONK
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8ONI
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![BU of 8oni by Molmil](/molmil-images/mine/8oni) | Human insulin in complex with the analytical antibody S1 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of analytical antibody S1 Fab, Insulin A chain, ... | Authors: | Johansson, E. | Deposit date: | 2023-04-03 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Macromolecular structure of insulin and IgE clonality impacts IgE-mediated activation of sensitized basophils To Be Published
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1J9M
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![BU of 1j9m by Molmil](/molmil-images/mine/1j9m) | K38H mutant of Streptomyces K15 DD-transpeptidase | Descriptor: | CHLORIDE ION, DD-transpeptidase, SODIUM ION | Authors: | Fonze, E, Rhazi, N, Nguyen-Disteche, M, Charlier, P. | Deposit date: | 2001-05-28 | Release date: | 2001-06-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Catalytic mechanism of the Streptomyces K15 DD-transpeptidase/penicillin-binding protein probed by site-directed mutagenesis and structural analysis. Biochemistry, 42, 2003
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1KMN
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1KMM
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8B0R
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![BU of 8b0r by Molmil](/molmil-images/mine/8b0r) | Structure of the CalpL/cA4 complex | Descriptor: | Cyclic tetraadenosine monophosphate (cA4), SMODS-associated and fused to various effectors domain-containing protein, SULFATE ION, ... | Authors: | Schneberger, N, Hagelueken, G. | Deposit date: | 2022-09-08 | Release date: | 2022-11-16 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Antiviral signalling by a cyclic nucleotide activated CRISPR protease. Nature, 614, 2023
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8B0U
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![BU of 8b0u by Molmil](/molmil-images/mine/8b0u) | Structure of the CalpL/T10 complex | Descriptor: | CalpT10, GLYCEROL, SAVED domain-containing protein, ... | Authors: | Schneberger, N, Hagelueken, G. | Deposit date: | 2022-09-08 | Release date: | 2022-11-16 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.29 Å) | Cite: | Antiviral signalling by a cyclic nucleotide activated CRISPR protease. Nature, 614, 2023
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8QJK
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![BU of 8qjk by Molmil](/molmil-images/mine/8qjk) | Structure of the cytoplasmic domain of csx23 from Vibrio cholera in complex with cyclic tetra-adenylate (cA4) | Descriptor: | ACETYL GROUP, Cyclic tetraadenosine monophosphate (cA4), SODIUM ION, ... | Authors: | McMahon, S.A, McQuarrie, S, Gloster, T.M, Gruschow, S, White, M.F. | Deposit date: | 2023-09-13 | Release date: | 2024-08-07 | Method: | X-RAY DIFFRACTION (1.761 Å) | Cite: | A cyclic-nucleotide binding membrane protein provides CRISPR-mediated antiphage defence in Vibrio cholera To Be Published
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1SKF
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![BU of 1skf by Molmil](/molmil-images/mine/1skf) | CRYSTAL STRUCTURE OF THE STREPTOMYCES K15 DD-TRANSPEPTIDASE | Descriptor: | D-ALANYL-D-ALANINE TRANSPEPTIDASE | Authors: | Fonze, E, Charlier, P. | Deposit date: | 1998-08-20 | Release date: | 1999-08-20 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The crystal structure of a penicilloyl-serine transferase of intermediate penicillin sensitivity. The DD-transpeptidase of streptomyces K15. J.Biol.Chem., 274, 1999
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1ES3
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![BU of 1es3 by Molmil](/molmil-images/mine/1es3) | C98A mutant of streptomyces K15 DD-transpeptidase | Descriptor: | DD-TRANSPEPTIDASE, SODIUM ION | Authors: | Fonze, E, Charlier, P. | Deposit date: | 2000-04-07 | Release date: | 2000-05-03 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Catalytic mechanism of the Streptomyces K15 DD-transpeptidase/penicillin-binding protein probed by site-directed mutagenesis and structural analysis. Biochemistry, 42, 2003
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1ES4
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![BU of 1es4 by Molmil](/molmil-images/mine/1es4) | C98N mutant of streptomyces K15 DD-transpeptidase | Descriptor: | DD-TRANSPEPTIDASE | Authors: | Fonze, E, Charlier, P. | Deposit date: | 2000-04-07 | Release date: | 2000-05-03 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Catalytic mechanism of the Streptomyces K15 DD-transpeptidase/penicillin-binding protein probed by site-directed mutagenesis and structural analysis. Biochemistry, 42, 2003
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1ES5
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5O6C
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![BU of 5o6c by Molmil](/molmil-images/mine/5o6c) | Crystal Structure of a threonine-selective RCR E3 ligase | Descriptor: | E3 ubiquitin-protein ligase MYCBP2, ZINC ION | Authors: | Pao, K.-C, Rafie, K.Z, van Aalten, D, Virdee, S. | Deposit date: | 2017-06-06 | Release date: | 2018-04-18 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity. Nature, 556, 2018
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1ES2
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![BU of 1es2 by Molmil](/molmil-images/mine/1es2) | S96A mutant of streptomyces K15 DD-transpeptidase | Descriptor: | DD-TRANSPEPTIDASE | Authors: | Fonze, E, Charlier, P. | Deposit date: | 2000-04-07 | Release date: | 2000-05-03 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Catalytic mechanism of the Streptomyces K15 DD-transpeptidase/penicillin-binding protein probed by site-directed mutagenesis and structural analysis. Biochemistry, 42, 2003
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6NYT
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![BU of 6nyt by Molmil](/molmil-images/mine/6nyt) | Munc13-1 C2B-domain, calcium bound | Descriptor: | CALCIUM ION, CHLORIDE ION, GLYCEROL, ... | Authors: | Tomchick, D.R, Rizo, J, Machius, M, Lu, J. | Deposit date: | 2019-02-12 | Release date: | 2019-02-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.369 Å) | Cite: | Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis. Nat. Struct. Mol. Biol., 17, 2010
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6NYC
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![BU of 6nyc by Molmil](/molmil-images/mine/6nyc) | Munc13-1 C2B-domain, calcium free | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, Munc13-1 | Authors: | Tomchick, D.R, Rizo, J, Machius, M, Lu, J. | Deposit date: | 2019-02-11 | Release date: | 2019-02-20 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.893 Å) | Cite: | Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis. Nat. Struct. Mol. Biol., 17, 2010
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1ESI
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1DIL
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![BU of 1dil by Molmil](/molmil-images/mine/1dil) | SIALIDASE FROM SALMONELLA TYPHIMURIUM COMPLEXED WITH APANA AND EPANA INHIBITORS | Descriptor: | (1R)-4-acetamido-1,5-anhydro-2,4-dideoxy-1-phosphono-D-glycero-D-galacto-octitol, (1S)-4-acetamido-1,5-anhydro-2,4-dideoxy-1-phosphono-D-glycero-D-galacto-octitol, POTASSIUM ION, ... | Authors: | Garman, E.F, Crennell, S.C, Vimr, E.R, Laver, W.G, Taylor, G.L. | Deposit date: | 1996-04-23 | Release date: | 1996-12-07 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The structures of Salmonella typhimurium LT2 neuraminidase and its complexes with three inhibitors at high resolution. J.Mol.Biol., 259, 1996
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1DP7
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![BU of 1dp7 by Molmil](/molmil-images/mine/1dp7) | COCRYSTAL STRUCTURE OF RFX-DBD IN COMPLEX WITH ITS COGNATE X-BOX BINDING SITE | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, DNA (5'-D(*CP*GP*(BRU)P*TP*AP*CP*CP*AP*(BRU)P*GP*GP*TP*AP*AP*CP*G)-3'), ... | Authors: | Gajiwala, K.S, Chen, H, Cornille, F, Roques, B.P, Reith, W, Mach, B, Burley, S.K. | Deposit date: | 1999-12-23 | Release date: | 2000-03-06 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding. Nature, 403, 2000
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1GPU
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![BU of 1gpu by Molmil](/molmil-images/mine/1gpu) | Transketolase complex with reaction intermediate | Descriptor: | 2-[3-[(4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL]-2-(1,2-DIHYDROXYETHYL)-4-METHYL-1,3-THIAZOL-3-IUM-5-YL]ETHYL TRIHYDROGEN DIPHOSPHATE, CALCIUM ION, TRANSKETOLASE 1 | Authors: | Fiedler, E, Thorell, S, Sandalova, T, Koenig, S, Schneider, G. | Deposit date: | 2001-11-09 | Release date: | 2002-02-11 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Snapshot of a Key Intermediate in Enzymatic Thiamin Catalysis: Crystal Structure of the Alpha-Carbanion of (Alpha,Beta-Dihydroxyethyl)-Thiamin Diphosphate in the Active Site of Transketolase from Saccharomyces Cerevisiae. Proc.Natl.Acad.Sci.USA, 99, 2002
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1DIM
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![BU of 1dim by Molmil](/molmil-images/mine/1dim) | SIALIDASE FROM SALMONELLA TYPHIMURIUM COMPLEXED WITH EPANA INHIBITOR | Descriptor: | (1R)-4-acetamido-1,5-anhydro-2,4-dideoxy-1-phosphono-D-glycero-D-galacto-octitol, POTASSIUM ION, SIALIDASE | Authors: | Garman, E.F, Crennell, S.C, Vimr, E.R, Laver, W.G, Taylor, G.L. | Deposit date: | 1996-04-23 | Release date: | 1996-12-07 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The structures of Salmonella typhimurium LT2 neuraminidase and its complexes with three inhibitors at high resolution. J.Mol.Biol., 259, 1996
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7NB0
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![BU of 7nb0 by Molmil](/molmil-images/mine/7nb0) | Structure of the DNA-binding domain of SEPALLATA 3 | Descriptor: | Developmental protein SEPALLATA 3 | Authors: | Zubieta, C, Nanao, M.H. | Deposit date: | 2021-01-25 | Release date: | 2021-07-14 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The intervening domain is required for DNA-binding and functional identity of plant MADS transcription factors. Nat Commun, 12, 2021
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8CIP
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7NTR
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