8KBE
 
 | | Structure of CbTad1 complexed with 1',3'-cADPR | | Descriptor: | (2R,3R,3aS,5S,6R,7S,8R,11R,13S,15aR)-2-(6-amino-9H-purin-9-yl)-3,6,7,11,13-pentahydroxyoctahydro-2H,5H,11H,13H-5,8-epoxy-11lambda~5~,13lambda~5~-furo[2,3-g][1,3,5,9,2,4]tetraoxadiphosphacyclotetradecine-11,13-dione, Thoeris anti-defense 1 | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-08-04 | | Release date: | 2024-08-07 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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8KBF
 | | Structure of CbTad1 complexed with 1',3'-cADPR and cA3 | | Descriptor: | (2-ACETYL-5-METHYLANILINO)(2,6-DIBROMOPHENYL)ACETAMIDE, (2R,3R,3aS,5S,6R,7S,8R,11R,13S,15aR)-2-(6-amino-9H-purin-9-yl)-3,6,7,11,13-pentahydroxyoctahydro-2H,5H,11H,13H-5,8-epoxy-11lambda~5~,13lambda~5~-furo[2,3-g][1,3,5,9,2,4]tetraoxadiphosphacyclotetradecine-11,13-dione, Thoeris anti-defense 1 | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-08-04 | | Release date: | 2024-08-07 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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8KBB
 | | Structure of apo-CmTad1 | | Descriptor: | Thoeris anti-defense 1, ZINC ION | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-08-04 | | Release date: | 2024-08-07 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (2.56 Å) | | Cite: | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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8KBL
 | | Structure of AcrIIA7 complexed with 1',3'-cADPR and cGG | | Descriptor: | (2R,3R,3aS,5S,6R,7S,8R,11R,13S,15aR)-2-(6-amino-9H-purin-9-yl)-3,6,7,11,13-pentahydroxyoctahydro-2H,5H,11H,13H-5,8-epoxy-11lambda~5~,13lambda~5~-furo[2,3-g][1,3,5,9,2,4]tetraoxadiphosphacyclotetradecine-11,13-dione, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Inhibitor of Type II CRISPR-Cas system | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-08-04 | | Release date: | 2024-08-07 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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8KBK
 | | Structure of AcrIIA7 complexed with 1',2'-cADPR and cGG | | Descriptor: | (1S,3R,4R,6R,9S,11R,14R,15S,16R,18R)-4-(6-amino-9H-purin-9-yl)-9,11,15,16,18-pentahydroxy-2,5,8,10,12,17-hexaoxa-9lambda~5~,11lambda~5~-diphosphatricyclo[12.2.1.1~3,6~]octadecane-9,11-dione, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Inhibitor of Type II CRISPR-Cas system | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-08-04 | | Release date: | 2024-08-07 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (2.28 Å) | | Cite: | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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8KBD
 | | Structure of CmTad1 complexed with cAAG | | Descriptor: | Thoeris anti-defense 1, ZINC ION, cAAG | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-08-04 | | Release date: | 2024-08-07 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (3.15 Å) | | Cite: | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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8KBI
 | | Structure of apo-AcrIIA7 | | Descriptor: | Inhibitor of Type II CRISPR-Cas system | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-08-04 | | Release date: | 2024-08-07 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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8KBM
 | | Structure of AcrIIA7 complexed with cGG | | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Inhibitor of Type II CRISPR-Cas system | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-08-04 | | Release date: | 2024-08-07 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (1.38 Å) | | Cite: | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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8KBJ
 | | Structure of HgmTad2 complexed with 1',2'-cADPR | | Descriptor: | (1S,3R,4R,6R,9S,11R,14R,15S,16R,18R)-4-(6-amino-9H-purin-9-yl)-9,11,15,16,18-pentahydroxy-2,5,8,10,12,17-hexaoxa-9lambda~5~,11lambda~5~-diphosphatricyclo[12.2.1.1~3,6~]octadecane-9,11-dione, Inhibitor of Type II CRISPR-Cas system | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-08-04 | | Release date: | 2024-08-21 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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8KBG
 | | Structure of CbTad1 complexed with 2',3'-cGAMP | | Descriptor: | Thoeris anti-defense 1, cGAMP | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-08-04 | | Release date: | 2024-08-21 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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8KBC
 | | Structure of CmTad1 complexed with cAAA | | Descriptor: | (2-ACETYL-5-METHYLANILINO)(2,6-DIBROMOPHENYL)ACETAMIDE, Thoeris anti-defense 1, ZINC ION | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-08-04 | | Release date: | 2024-08-21 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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8KBH
 | | Structure of CbTad1 complexed with 2',3'-cGAMP and cA3 | | Descriptor: | (2-ACETYL-5-METHYLANILINO)(2,6-DIBROMOPHENYL)ACETAMIDE, Thoeris anti-defense 1, cGAMP | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-08-04 | | Release date: | 2024-08-21 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (1.54 Å) | | Cite: | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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8WJE
 | | Structure of apo-SPO1 Tad2 | | Descriptor: | Gp34.65 | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-09-25 | | Release date: | 2024-09-25 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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8FLM
 | | Cryo-EM structure of STING oligomer bound to cGAMP, NVS-STG2 and C53 | | Descriptor: | 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide, 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid, Stimulator of interferon genes protein, ... | | Authors: | Li, J, Canham, S.M, Zhang, X, Bai, X, Feng, Y. | | Deposit date: | 2022-12-21 | | Release date: | 2023-11-01 | | Last modified: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Activation of human STING by a molecular glue-like compound.
Nat.Chem.Biol., 20, 2024
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8WJD
 | | Structure of SptTad2 complexed with cGG | | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), SptTad2 | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-09-25 | | Release date: | 2024-09-25 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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8WJC
 | | Structure of AcrIIA7 complexed with 3'3'-cGAMP | | Descriptor: | 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, Inhibitor of Type II CRISPR-Cas system | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-09-25 | | Release date: | 2024-09-25 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (2.11 Å) | | Cite: | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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8FLK
 | | Cryo-EM structure of STING oligomer bound to cGAMP and NVS-STG2 | | Descriptor: | 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid, Stimulator of interferon genes protein, cGAMP | | Authors: | Li, J, Canham, S.M, Zhang, X, Bai, X, Feng, Y. | | Deposit date: | 2022-12-21 | | Release date: | 2023-11-01 | | Last modified: | 2025-05-21 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Activation of human STING by a molecular glue-like compound.
Nat.Chem.Biol., 20, 2024
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8GMU
 | | Structure of lambda repressor in complex with RecA filament | | Descriptor: | DNA (5'-D(P*TP*TP*TP*TP*TP*T)-3'), MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | | Authors: | Gao, B, Feng, Y. | | Deposit date: | 2022-08-22 | | Release date: | 2022-12-21 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (2.78 Å) | | Cite: | Structural basis for regulation of SOS response in bacteria.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8GMT
 | | Structure of UmuD in complex with RecA filament | | Descriptor: | DNA (5'-D(P*TP*TP*TP*TP*TP*T)-3'), DNA polymerase V subunit UmuD, MAGNESIUM ION, ... | | Authors: | Gao, B, Feng, Y. | | Deposit date: | 2022-08-22 | | Release date: | 2022-12-21 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.31 Å) | | Cite: | Structural basis for regulation of SOS response in bacteria.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8GMS
 | | Structure of LexA in complex with RecA filament | | Descriptor: | DNA (5'-D(P*TP*TP*TP*TP*TP*T)-3'), LexA repressor, MAGNESIUM ION, ... | | Authors: | Gao, B, Feng, Y. | | Deposit date: | 2022-08-22 | | Release date: | 2022-12-21 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.31 Å) | | Cite: | Structural basis for regulation of SOS response in bacteria.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8VMH
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8VO4
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8VS0
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8VT6
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8VMM
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