7O43
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7O41
| Hexameric composite model of the Inner Membrane Complex (IMC) with the Arches from the fully-assembled R388 type IV secretion system determined by cryo-EM. | Descriptor: | TrwG protein, TrwK protein, TrwM protein | Authors: | Mace, K, Vadakkepat, A.K, Lukoyanova, N, Waksman, G. | Deposit date: | 2021-04-04 | Release date: | 2022-06-22 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (7.6 Å) | Cite: | Cryo-EM structure of a type IV secretion system. Nature, 607, 2022
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7O3V
| Stalk complex structure (TrwJ/VirB5-TrwI/VirB6) from the fully-assembled R388 type IV secretion system determined by cryo-EM. | Descriptor: | TrwI protein, TrwJ protein | Authors: | Mace, K, Vadakkepat, A.K, Lukoyanova, N, Waksman, G. | Deposit date: | 2021-04-03 | Release date: | 2022-06-22 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Cryo-EM structure of a type IV secretion system. Nature, 607, 2022
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7O3J
| O-layer structure (TrwH/VirB7, TrwF/VirB9CTD, TrwE/VirB10CTD) of the outer membrane core complex from the fully-assembled R388 type IV secretion system determined by cryo-EM. | Descriptor: | TrwE protein, TrwF protein, TrwH protein | Authors: | Mace, K, Vadakkepat, A.K, Lukoyanova, N, Waksman, G. | Deposit date: | 2021-04-01 | Release date: | 2022-06-22 | Last modified: | 2022-07-20 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Cryo-EM structure of a type IV secretion system. Nature, 607, 2022
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7O3T
| I-layer structure (TrwF/VirB9NTD, TrwE/VirB10NTD) of the outer membrane core complex from the fully-assembled R388 type IV secretion system determined by cryo-EM. | Descriptor: | TrwE protein, TrwF protein | Authors: | Mace, K, Vadakkepat, A.K, Lukoyanova, N, Waksman, G. | Deposit date: | 2021-04-03 | Release date: | 2022-06-22 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM structure of a type IV secretion system. Nature, 607, 2022
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7O42
| TrwK/VirB4unbound trimer of dimers complex (with Hcp1) from the R388 type IV secretion system determined by cryo-EM. | Descriptor: | TrwK protein,Protein hcp1 | Authors: | Vadakkepat, A.K, Mace, K, Lukoyanova, N, Waksman, G. | Deposit date: | 2021-04-04 | Release date: | 2022-06-22 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Cryo-EM structure of a type IV secretion system. Nature, 607, 2022
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7OIU
| Inner Membrane Complex (IMC) protomer structure (TrwM/VirB3, TrwK/VirB4, TrwG/VirB8tails) from the fully-assembled R388 type IV secretion system determined by cryo-EM. | Descriptor: | TrwG protein, TrwK protein, TrwM protein | Authors: | Mace, K, Vadakkepat, A.K, Lukoyanova, N, Waksman, G. | Deposit date: | 2021-05-12 | Release date: | 2022-06-22 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Cryo-EM structure of a type IV secretion system. Nature, 607, 2022
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6SX4
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6SWZ
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6JN2
| Crystal structure of the coiled-coil domains of human DOT1L in complex with AF10 | Descriptor: | Histone-lysine N-methyltransferase, H3 lysine-79 specific, Protein AF-10 | Authors: | Song, X, Wang, M, Yang, N, Xu, R.M. | Deposit date: | 2019-03-13 | Release date: | 2019-09-18 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | A higher-order configuration of the heterodimeric DOT1L-AF10 coiled-coil domains potentiates their leukemogenenic activity. Proc.Natl.Acad.Sci.USA, 116, 2019
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7NST
| ColicinE9 partial translocation complex | Descriptor: | Colicin-E9, Outer membrane protein F, Tol-Pal system protein TolB | Authors: | Webby, M.N, Kleanthous, C, Lukoyanova, N, Housden, N.G. | Deposit date: | 2021-03-08 | Release date: | 2021-08-11 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Porin threading drives receptor disengagement and establishes active colicin transport through Escherichia coli OmpF. Embo J., 40, 2021
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7NSU
| ColicinE9 intact translocation complex | Descriptor: | Colicin-E9, Outer membrane protein F, Tol-Pal system protein TolB, ... | Authors: | Webby, M.N, Kleanthous, C, Lukoyanova, N, Housden, N.G. | Deposit date: | 2021-03-08 | Release date: | 2021-08-11 | Last modified: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Porin threading drives receptor disengagement and establishes active colicin transport through Escherichia coli OmpF. Embo J., 40, 2021
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7OK0
| Cryo-EM structure of the Sulfolobus acidocaldarius RNA polymerase at 2.88 A | Descriptor: | Conserved protein, DNA-directed RNA polymerase subunit A', DNA-directed RNA polymerase subunit A'', ... | Authors: | Pilotto, S, Fouqueau, T, Lukoyanova, N, Sheppard, C, Lucas-Staat, S, Diaz-Santin, L.M, Matelska, D, Prangishvili, D, Cheung, A.C.M, Werner, F. | Deposit date: | 2021-05-17 | Release date: | 2021-08-25 | Last modified: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis of RNA polymerase inhibition by viral and host factors. Nat Commun, 12, 2021
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7OQY
| Cryo-EM structure of the cellular negative regulator TFS4 bound to the archaeal RNA polymerase | Descriptor: | Conserved protein, DNA-directed RNA polymerase subunit A', DNA-directed RNA polymerase subunit A'', ... | Authors: | Pilotto, S, Fouqueau, T, Lukoyanova, N, Sheppard, C, Lucas-Staat, S, Diaz-Santin, L.M, Matelska, D, Prangishvili, D, Cheung, A.C.M, Werner, F. | Deposit date: | 2021-06-04 | Release date: | 2021-08-25 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.61 Å) | Cite: | Structural basis of RNA polymerase inhibition by viral and host factors. Nat Commun, 12, 2021
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7OQ4
| Cryo-EM structure of the ATV RNAP Inhibitory Protein (RIP) bound to the DNA-binding channel of the host's RNA polymerase | Descriptor: | Conserved protein, DNA-directed RNA polymerase subunit A', DNA-directed RNA polymerase subunit A'', ... | Authors: | Pilotto, S, Fouqueau, T, Lukoyanova, N, Sheppard, C, Lucas-Staat, S, Diaz-Santin, L.M, Matelska, D, Prangishvili, D, Cheung, A.C.M, Werner, F. | Deposit date: | 2021-06-02 | Release date: | 2021-08-25 | Last modified: | 2021-10-13 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Structural basis of RNA polymerase inhibition by viral and host factors. Nat Commun, 12, 2021
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7OVB
| L. pneumophila Type IV Coupling Complex (T4CC) with density for DotY N-terminal and middle domains | Descriptor: | DotY, DotZ, IcmJ (DotN), ... | Authors: | Mace, K, Meir, A, Lukoyanova, N, Waksman, G. | Deposit date: | 2021-06-14 | Release date: | 2021-12-01 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.61 Å) | Cite: | Proteins DotY and DotZ modulate the dynamics and localization of the type IVB coupling complex of Legionella pneumophila. Mol.Microbiol., 117, 2022
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7PAG
| The pore conformation of lymphocyte perforin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Perforin-1 | Authors: | Ivanova, M.E, Lukoyanova, N, Malhotra, S, Topf, M, Trapani, J.A, Voskoboinik, I, Saibil, H.R. | Deposit date: | 2021-07-29 | Release date: | 2022-02-16 | Last modified: | 2022-02-23 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | The pore conformation of lymphocyte perforin. Sci Adv, 8, 2022
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6SZ9
| Type IV Coupling Complex (T4CC) from L. pneumophila. | Descriptor: | DotY, DotZ, IcmJ (DotN), ... | Authors: | Mace, K, Meir, A, Lukoyanova, N, Waksman, G. | Deposit date: | 2019-10-02 | Release date: | 2020-05-13 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila. Nat Commun, 11, 2020
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1LQV
| Crystal structure of the Endothelial protein C receptor with phospholipid in the groove in complex with Gla domain of protein C. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Endothelial protein C receptor, ... | Authors: | Oganesyan, V, Oganesyan, N, Terzyan, S, Dongfeng, Q, Dauter, Z, Esmon, N.L, Esmon, C.T. | Deposit date: | 2002-05-13 | Release date: | 2002-06-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The crystal structure of the endothelial protein C receptor and a bound phospholipid. J.Biol.Chem., 277, 2002
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2WKO
| Structure of metal loaded Pathogenic SOD1 Mutant G93A. | Descriptor: | COPPER (II) ION, IODIDE ION, SUPEROXIDE DISMUTASE [CU-ZN], ... | Authors: | Antonyuk, S.V, Galaleldeen, A, Strange, R, Whitson, L, Narayana, N, Taylor, A, Schuermann, J.P, Holloway, S.P, Hasnain, S.S, Hart, P.J. | Deposit date: | 2009-06-16 | Release date: | 2009-11-24 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Structural and Biophysical Properties of Metal-Free Pathogenic Sod1 Mutants A4V and G93A. Arch.Biochem.Biophys., 492, 2009
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1L8J
| Crystal Structure of the Endothelial Protein C Receptor and Bound Phospholipid Molecule | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Endothelial protein C receptor, ... | Authors: | Oganesyan, V, Oganesyan, N, Terzyan, S, Dongfeng, Q, Dauter, Z, Esmon, N.L, Esmon, C.T. | Deposit date: | 2002-03-20 | Release date: | 2002-06-26 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The crystal structure of the endothelial protein C receptor and a bound phospholipid. J.Biol.Chem., 277, 2002
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2UXR
| Complex with isocitrate and the protein isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila | Descriptor: | GLYCEROL, ISOCITRATE DEHYDROGENASE, ISOCITRIC ACID, ... | Authors: | Fedoy, A.-E, Yang, N, Martinez, A, Leiros, H.-K.S, Steen, I.H. | Deposit date: | 2007-03-29 | Release date: | 2008-02-05 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural and Functional Properties of Isocitrate Dehydrogenase from the Psychrophilic Bacterium Desulfotalea Psychrophila Reveal a Cold -Active Enzyme with an Unusual High Thermal J.Mol.Biol., 372, 2007
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2UXQ
| Isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila: biochemical properties and crystal structure analysis | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, ISOCITRATE DEHYDROGENASE NATIVE, ... | Authors: | Fedoy, A.-E, Yang, N, Martinez, A, Leiros, H.-K.S, Steen, I.H. | Deposit date: | 2007-03-29 | Release date: | 2008-02-05 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural and Functional Properties of Isocitrate Dehydrogenase from the Psychrophilic Bacterium Desulfotalea Psychrophila Reveal a Cold -Active Enzyme with an Unusual High Thermal J.Mol.Biol., 372, 2007
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5BTR
| Crystal structure of SIRT1 in complex with resveratrol and an AMC-containing peptide | Descriptor: | AMC-containing peptide, NAD-dependent protein deacetylase sirtuin-1, RESVERATROL, ... | Authors: | Cao, D, Wang, M, Qiu, X, Liu, D, Jiang, H, Yang, N, Xu, R.M. | Deposit date: | 2015-06-03 | Release date: | 2015-07-08 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol Genes Dev., 29, 2015
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6A7F
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