5Y6M
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![BU of 5y6m by Molmil](/molmil-images/mine/5y6m) | Zika virus helicase in complex with ADP-AlF3 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ALUMINUM FLUORIDE, Helicase domain from Genome polyprotein, ... | Authors: | Yang, X.Y, Chen, C, Tian, H.L, Chi, H, Mu, Z.Y, Zhang, T.Q, Yang, K.L, Zhao, Q, Liu, X.H, Wang, Z.F, Ji, X.Y, Yang, H.T. | Deposit date: | 2017-08-12 | Release date: | 2018-07-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.002 Å) | Cite: | Mechanism of ATP hydrolysis by the Zika virus helicase. FASEB J., 32, 2018
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4YNA
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![BU of 4yna by Molmil](/molmil-images/mine/4yna) | Oxidized YfiR | Descriptor: | SULFATE ION, YfiR | Authors: | Xu, M, Jiang, T. | Deposit date: | 2015-03-09 | Release date: | 2015-04-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal structures of YfiR from Pseudomonas aeruginosa in two redox states Biochem.Biophys.Res.Commun., 461, 2015
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4YN9
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![BU of 4yn9 by Molmil](/molmil-images/mine/4yn9) | YfiR mutant-C110S | Descriptor: | SULFATE ION, YfiR | Authors: | Xu, M, Jiang, T. | Deposit date: | 2015-03-09 | Release date: | 2015-04-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Crystal structures of YfiR from Pseudomonas aeruginosa in two redox states Biochem.Biophys.Res.Commun., 461, 2015
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3AJF
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![BU of 3ajf by Molmil](/molmil-images/mine/3ajf) | |
8JFK
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![BU of 8jfk by Molmil](/molmil-images/mine/8jfk) | PhK holoenzyme in inactive state, muscle isoform | Descriptor: | Calmodulin-1, FARNESYL, Phosphorylase b kinase gamma catalytic chain, ... | Authors: | Yang, X.K, Xiao, J.Y. | Deposit date: | 2023-05-18 | Release date: | 2024-04-03 | Last modified: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Architecture and activation of human muscle phosphorylase kinase. Nat Commun, 15, 2024
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8JFL
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![BU of 8jfl by Molmil](/molmil-images/mine/8jfl) | PhK holoenzyme in active state, muscle isoform | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, FARNESYL, Phosphorylase b kinase gamma catalytic chain, ... | Authors: | Yang, X.K, Xiao, J.Y. | Deposit date: | 2023-05-18 | Release date: | 2024-04-03 | Last modified: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Architecture and activation of human muscle phosphorylase kinase. Nat Commun, 15, 2024
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5YTX
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![BU of 5ytx by Molmil](/molmil-images/mine/5ytx) | Crystal structure of YB1 cold-shock domain in complex with UCAACU | Descriptor: | Nuclease-sensitive element-binding protein 1, RNA (5'-R(P*UP*CP*AP*AP*CP*U)-3') | Authors: | Yang, X, Huang, Y. | Deposit date: | 2017-11-20 | Release date: | 2018-12-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.551 Å) | Cite: | Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA. J.Biol.Chem., 294, 2019
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5YTT
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![BU of 5ytt by Molmil](/molmil-images/mine/5ytt) | Crystal structure of YB1 cold-shock domain in complex with UCAUGU | Descriptor: | Nuclease-sensitive element-binding protein 1, RNA (5'-R(P*UP*CP*AP*UP*GP*U)-3'), SULFATE ION | Authors: | Yang, X, Huang, Y. | Deposit date: | 2017-11-20 | Release date: | 2018-12-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA. J.Biol.Chem., 294, 2019
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5YTS
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![BU of 5yts by Molmil](/molmil-images/mine/5yts) | Crystal structure of YB1 cold-shock domain in complex with UCUUCU | Descriptor: | Nuclease-sensitive element-binding protein 1, RNA (5'-R(P*CP*UP*UP*C)-3'), SULFATE ION | Authors: | Yang, X, Huang, Y. | Deposit date: | 2017-11-20 | Release date: | 2018-12-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.77 Å) | Cite: | Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA. J.Biol.Chem., 294, 2019
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5YTV
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![BU of 5ytv by Molmil](/molmil-images/mine/5ytv) | Crystal structure of YB1 cold-shock domain in complex with UCAUCU | Descriptor: | Nuclease-sensitive element-binding protein 1, RNA (5'-R(P*UP*CP*AP*UP*CP*U)-3') | Authors: | Yang, X, Huang, Y. | Deposit date: | 2017-11-20 | Release date: | 2018-12-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA. J.Biol.Chem., 294, 2019
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5D2L
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![BU of 5d2l by Molmil](/molmil-images/mine/5d2l) | |
5YUD
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![BU of 5yud by Molmil](/molmil-images/mine/5yud) | Flagellin derivative in complex with the NLR protein NAIP5 | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Baculoviral IAP repeat-containing protein 1e, Phase 2 flagellin,Flagellin | Authors: | Yang, X.R, Yang, F, Wang, W.G, Lin, G.Z. | Deposit date: | 2017-11-21 | Release date: | 2018-01-03 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.28 Å) | Cite: | Structural basis for specific flagellin recognition by the NLR protein NAIP5. Cell Res., 28, 2018
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5ZOL
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![BU of 5zol by Molmil](/molmil-images/mine/5zol) | Crystal structure of a three sites mutantion of FSAA complexed with HA and product | Descriptor: | (3S,4S)-3,4-dihydroxy-4-(thiophen-2-yl)butan-2-one, 1-hydroxypropan-2-one, CHLORIDE ION, ... | Authors: | Wu, L, Yang, X.H, Yu, H.W, Zhou, J.H. | Deposit date: | 2018-04-13 | Release date: | 2019-06-12 | Last modified: | 2020-07-22 | Method: | X-RAY DIFFRACTION (2.172 Å) | Cite: | The engineering of decameric d-fructose-6-phosphate aldolase A by combinatorial modulation of inter- and intra-subunit interactions. Chem.Commun.(Camb.), 56, 2020
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7FEE
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![BU of 7fee by Molmil](/molmil-images/mine/7fee) | Crystal structure of the allosteric modulator ZCZ011 binding to CP55940-bound cannabinoid receptor 1 | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol, 6-methyl-3-[(1S)-2-nitro-1-thiophen-2-yl-ethyl]-2-phenyl-1H-indole, ... | Authors: | Wang, X, Zhao, C, Shao, Z. | Deposit date: | 2021-07-19 | Release date: | 2022-06-15 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1. Nat.Chem.Biol., 18, 2022
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8H3U
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![BU of 8h3u by Molmil](/molmil-images/mine/8h3u) | Inhibitor-bound EP, polyA model | Descriptor: | Enteropeptidase catalytic light chain, Enteropeptidase non-catalytic heavy chain | Authors: | Ding, Z.Y, Huang, H.J. | Deposit date: | 2022-10-09 | Release date: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase. Nat Commun, 13, 2022
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8H3S
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![BU of 8h3s by Molmil](/molmil-images/mine/8h3s) | Substrate-bound EP, polyA model | Descriptor: | Enteropeptidase catalytic light chain, Enteropeptidase non-catalytic heavy chain, Serine protease 1 | Authors: | Ding, Z.Y, Huang, H.J. | Deposit date: | 2022-10-09 | Release date: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase. Nat Commun, 13, 2022
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7WV9
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![BU of 7wv9 by Molmil](/molmil-images/mine/7wv9) | Allosteric modulator ZCZ011 binding to CP55940-bound cannabinoid receptor 1 in complex with Gi protein | Descriptor: | 2-[(1R,2R,5R)-5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-5-(2-methyloctan-2-yl)phenol, 6-methyl-3-[(1S)-2-nitro-1-thiophen-2-yl-ethyl]-2-phenyl-1H-indole, Cannabinoid receptor 1, ... | Authors: | Xu, Z, Shao, Z. | Deposit date: | 2022-02-10 | Release date: | 2022-06-15 | Last modified: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.36 Å) | Cite: | Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1. Nat.Chem.Biol., 18, 2022
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7CI0
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![BU of 7ci0 by Molmil](/molmil-images/mine/7ci0) | Microbial Hormone-sensitive lipase E53 mutant S162A | Descriptor: | 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | Authors: | Yang, X, Li, Z, Xu, X, Li, J. | Deposit date: | 2020-07-06 | Release date: | 2021-07-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Mechanism and Structural Insights Into a Novel Esterase, E53, Isolated From Erythrobacter longus . Front Microbiol, 12, 2021
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7CIH
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![BU of 7cih by Molmil](/molmil-images/mine/7cih) | Microbial Hormone-sensitive lipase E53 mutant S285G | Descriptor: | (4-nitrophenyl) hexanoate, 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, ... | Authors: | Yang, X, Li, Z, Xu, X, Li, J. | Deposit date: | 2020-07-07 | Release date: | 2021-07-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.789 Å) | Cite: | Mechanism and Structural Insights Into a Novel Esterase, E53, Isolated From Erythrobacter longus . Front Microbiol, 12, 2021
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7W8N
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![BU of 7w8n by Molmil](/molmil-images/mine/7w8n) | Microbial Hormone-sensitive lipase E53 wild type | Descriptor: | (4-nitrophenyl) hexanoate, 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, ... | Authors: | Yang, X, Li, Z, Xu, X, Li, J. | Deposit date: | 2021-12-08 | Release date: | 2022-02-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Mechanism and Structural Insights Into a Novel Esterase, E53, Isolated From Erythrobacter longus . Front Microbiol, 12, 2021
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7FCZ
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![BU of 7fcz by Molmil](/molmil-images/mine/7fcz) | Crystal Structure of human RIPK1 kinase domain in complex with a novel inhibitor | Descriptor: | N-[(3S)-7-(2-cyclopropylethynyl)-5-methyl-4-oxidanylidene-2,3-dihydro-1,5-benzoxazepin-3-yl]-5-(phenylmethyl)-4H-1,2,4-triazole-3-carboxamide, Receptor-interacting serine/threonine-protein kinase 1 | Authors: | Su, H.X, Xie, H, Nie, T.Q, Li, M.J, Xu, Y.C. | Deposit date: | 2021-07-15 | Release date: | 2022-01-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis. Angew.Chem.Int.Ed.Engl., 61, 2022
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7FD0
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![BU of 7fd0 by Molmil](/molmil-images/mine/7fd0) | Crystal Structure of human RIPK1 kinase domain in complex with a novel inhibitor | Descriptor: | N-[(3S)-5-methyl-7-[2-(oxan-4-yl)ethynyl]-4-oxidanylidene-2,3-dihydro-1,5-benzoxazepin-3-yl]-5-(phenylmethyl)-4H-1,2,4-triazole-3-carboxamide, Receptor-interacting serine/threonine-protein kinase 1 | Authors: | Su, H.X, Xie, H, Nie, T.Q, Li, M.J, Xu, Y.C. | Deposit date: | 2021-07-15 | Release date: | 2022-01-19 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis. Angew.Chem.Int.Ed.Engl., 61, 2022
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7V55
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![BU of 7v55 by Molmil](/molmil-images/mine/7v55) | |
7V53
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![BU of 7v53 by Molmil](/molmil-images/mine/7v53) | |
7WQX
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![BU of 7wqx by Molmil](/molmil-images/mine/7wqx) | Structure of Inactive-EP | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Enteropeptidase | Authors: | Yang, X.L, Ding, Z.Y, Huang, H.J. | Deposit date: | 2022-01-26 | Release date: | 2022-10-26 | Last modified: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Cryo-EM structures reveal the activation and substrate recognition mechanism of human enteropeptidase. Nat Commun, 13, 2022
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