7EJV
 
 | | The co-crystal structure of DYRK2 with YK-2-69 | | Descriptor: | Dual specificity tyrosine-phosphorylation-regulated kinase 2, [6-[[4-[2-(dimethylamino)-1,3-benzothiazol-6-yl]-5-fluoranyl-pyrimidin-2-yl]amino]pyridin-3-yl]-(4-ethylpiperazin-1-yl)methanone | | Authors: | Li, Z, Xiao, Y, Yuan, K, Kuang, W, Xiuquan, Y, Yang, P. | | Deposit date: | 2021-04-02 | | Release date: | 2022-04-06 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer.
Nat Commun, 13, 2022
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7DM2
 | | crystal structure of the M. tuberculosis phosphate ABC transport receptor PstS-1 in complex with Fab p4-170 | | Descriptor: | PHOSPHATE ION, Phosphate-binding protein PstS 1, heavy chain, ... | | Authors: | Ma, B, Freund, N, Xiang, Y. | | Deposit date: | 2020-12-01 | | Release date: | 2020-12-23 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis.
Nat Commun, 12, 2021
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7DM1
 | | crystal structure of the M.tuberculosis phosphate ABC transport receptor PstS-1 in complex with Fab p4-36 | | Descriptor: | PHOSPHATE ION, Phosphate-binding protein PstS 1, heavy chain, ... | | Authors: | Ma, B, Freund, N, Xiang, Y. | | Deposit date: | 2020-12-01 | | Release date: | 2020-12-23 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis.
Nat Commun, 12, 2021
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7DJ1
 | | Crystal structure of the G26C mutant of LeuT | | Descriptor: | LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION | | Authors: | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | | Deposit date: | 2020-11-19 | | Release date: | 2021-04-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.528 Å) | | Cite: | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states.
J.Biol.Chem., 296, 2021
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7DII
 | | Crystal structure of LeuT in lipidic cubic phase at pH 7 | | Descriptor: | LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION | | Authors: | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | | Deposit date: | 2020-11-19 | | Release date: | 2021-04-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.403 Å) | | Cite: | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states.
J.Biol.Chem., 296, 2021
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7DJ2
 | | Crystal structure of the G26C/E290S mutant of LeuT | | Descriptor: | LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ... | | Authors: | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | | Deposit date: | 2020-11-19 | | Release date: | 2021-04-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states.
J.Biol.Chem., 296, 2021
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7DIX
 | | Crystal structure of LeuT in lipidic cubic phase at pH 5 | | Descriptor: | Na(+):neurotransmitter symporter (Snf family), SELENOMETHIONINE, SODIUM ION | | Authors: | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | | Deposit date: | 2020-11-19 | | Release date: | 2021-04-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.49 Å) | | Cite: | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states.
J.Biol.Chem., 296, 2021
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7DJC
 | | Crystal structure of the G26C/Q250A mutant of LeuT | | Descriptor: | LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ... | | Authors: | Fan, J, Xiao, Y, Sun, Z, Zhou, X. | | Deposit date: | 2020-11-20 | | Release date: | 2021-04-07 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.701 Å) | | Cite: | Crystal structures of LeuT reveal conformational dynamics in the outward-facing states.
J.Biol.Chem., 296, 2021
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7WIF
 | | The THF-II riboswitch bound to H4B | | Descriptor: | 5,6,7,8-TETRAHYDROBIOPTERIN, RNA (50-MER) | | Authors: | Xu, L, Fang, X, Xiao, Y. | | Deposit date: | 2022-01-03 | | Release date: | 2023-01-18 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.86 Å) | | Cite: | Structural insights into translation regulation by the THF-II riboswitch.
Nucleic Acids Res., 51, 2023
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7WIE
 | | The THF-II riboswitch bound to 7DG | | Descriptor: | 7-DEAZAGUANINE, RNA (50-MER) | | Authors: | Xu, L, Fang, X, Xiao, Y. | | Deposit date: | 2022-01-03 | | Release date: | 2023-01-18 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural insights into translation regulation by the THF-II riboswitch.
Nucleic Acids Res., 51, 2023
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7WII
 | | The THF-II riboswitch bound to NPR | | Descriptor: | 2-AMINO-7,8-DIHYDRO-6-(1,2,3-TRIHYDROXYPROPYL)-4(1H)-PTERIDINONE, RNA (50-MER) | | Authors: | Xu, L, Fang, X, Xiao, Y. | | Deposit date: | 2022-01-03 | | Release date: | 2023-01-18 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Structural insights into translation regulation by the THF-II riboswitch.
Nucleic Acids Res., 51, 2023
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7WIA
 | | The apo-form of THF-II C22G riboswitch | | Descriptor: | RNA (50-MER) | | Authors: | Xu, L, Fang, X, Xiao, Y. | | Deposit date: | 2022-01-03 | | Release date: | 2023-01-18 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (3.22 Å) | | Cite: | Structural insights into translation regulation by the THF-II riboswitch.
Nucleic Acids Res., 51, 2023
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7WIB
 | | The THF-II riboswitch bound to THF | | Descriptor: | (6S)-5,6,7,8-TETRAHYDROFOLATE, RNA (50-MER) | | Authors: | Xu, L, Fang, X, Xiao, Y. | | Deposit date: | 2022-01-03 | | Release date: | 2023-01-18 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.83 Å) | | Cite: | Structural insights into translation regulation by the THF-II riboswitch.
Nucleic Acids Res., 51, 2023
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7WI9
 | | The THF-II riboswitch bound to THF and soaking with SeUrea | | Descriptor: | (6S)-5,6,7,8-TETRAHYDROFOLATE, RNA (50-MER), selenourea | | Authors: | Xu, L, Fang, X, Xiao, Y. | | Deposit date: | 2022-01-03 | | Release date: | 2023-01-18 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (2.98 Å) | | Cite: | Structural insights into translation regulation by the THF-II riboswitch.
Nucleic Acids Res., 51, 2023
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7XY1
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7XYC
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7Y3T
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7Y22
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7Y23
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7Y1C
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7Y5S
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7W68
 | | human single hexameric Mcm2-7 complex | | Descriptor: | DNA replication licensing factor MCM2, DNA replication licensing factor MCM3, DNA replication licensing factor MCM4, ... | | Authors: | Xu, N.N, Lin, Q.P, Liu, C.D, Tian, H.L, Xiang, Y, Zhu, G. | | Deposit date: | 2021-12-01 | | Release date: | 2023-03-08 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | human single hexameric Mcm2-7 complex
To Be Published
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7CZL
 | | Structural insights into a dimeric Psb27-photosystem II complex from a cyanobacterium Thermosynechococcus vulcanus | | Descriptor: | (1S)-2-(ALPHA-L-ALLOPYRANOSYLOXY)-1-[(TRIDECANOYLOXY)METHYL]ETHYL PALMITATE, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, ... | | Authors: | Pi, X, Huang, G, Xiao, Y. | | Deposit date: | 2020-09-09 | | Release date: | 2021-01-20 | | Last modified: | 2021-02-10 | | Method: | ELECTRON MICROSCOPY (3.78 Å) | | Cite: | Structural insights into a dimeric Psb27-photosystem II complex from a cyanobacterium Thermosynechococcus vulcanus .
Proc.Natl.Acad.Sci.USA, 118, 2021
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5YGI
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5VRM
 | | CRYSTAL STRUCTURE OF THE INHA FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH AN12855, EBSI 4333. | | Descriptor: | Enoyl-[acyl-carrier-protein] reductase [NADH], [[(2~{R},3~{S},4~{R},5~{R})-5-(3-aminocarbonylpyridin-1-ium-1-yl)-3-oxidanyl-4-[[1-oxidanyl-6-[4-(trifluoromethyl)phenoxy]-3~{H}-2,1$l^{4}-benzoxaborol-1-yl]oxy]oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate | | Authors: | Abendroth, J, Edwards, T.E, Lorimer, D. | | Deposit date: | 2017-05-11 | | Release date: | 2018-05-16 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Discovery of a cofactor-independent inhibitor ofMycobacterium tuberculosisInhA.
Life Sci Alliance, 1, 2018
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