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5VZ3
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BU of 5vz3 by Molmil
Growth Factor Crystal Structure at 1.97 Angstrom Resolution
Descriptor: Growth/differentiation factor 15
Authors:Lakshminarasimhan, D, White, A, Suto, R.K.
Deposit date:2017-05-26
Release date:2017-09-27
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
Nature, 550, 2017
5WBI
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BU of 5wbi by Molmil
Crystal structure of the Arabidopsis thaliana Raptor
Descriptor: Regulatory-associated protein of TOR 1
Authors:Pavletich, N.P, Jiang, X.
Deposit date:2017-06-29
Release date:2017-12-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
5CET
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BU of 5cet by Molmil
Crystal structure of Rv2837c
Descriptor: Bifunctional oligoribonuclease and PAP phosphatase NrnA, MANGANESE (II) ION
Authors:Wang, F, He, Q, Zhu, D, Liu, S, Gu, L.
Deposit date:2015-07-07
Release date:2015-12-23
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Biochemical Insight into the Mechanism of Rv2837c from Mycobacterium tuberculosis as a c-di-NMP Phosphodiesterase
J.Biol.Chem., 291, 2016
5WBU
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BU of 5wbu by Molmil
Crystal structure of mTOR(deltaN)-mLST8-PRAS40(alpha-helix & beta-strand) complex
Descriptor: Proline-rich AKT1 substrate 1, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8
Authors:Pavletich, N.P, Yang, H.
Deposit date:2017-06-29
Release date:2017-12-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.42 Å)
Cite:Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
5WBJ
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BU of 5wbj by Molmil
Crystal structure of the arabidopsis thaliana Raptor in complex with the TOS peptide of human 4EBP1
Descriptor: Eukaryotic translation initiation factor 4E-binding protein 1, Regulatory-associated protein of TOR 1
Authors:Pavletich, N.P, Jiang, X.
Deposit date:2017-06-29
Release date:2017-12-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
5WBY
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BU of 5wby by Molmil
Crystal structure of mTOR(deltaN)-mLST8-PRAS40(beta-strand) complex
Descriptor: Proline-rich AKT1 substrate 1, Serine/threonine-protein kinase mTOR, Target of rapamycin complex subunit LST8
Authors:Pavletich, N.P, Yang, H.
Deposit date:2017-06-29
Release date:2017-12-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.
Nature, 552, 2017
5X0S
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BU of 5x0s by Molmil
Solution NMR structure of peptide toxin SsTx from Scolopendra subspinipes mutilans
Descriptor: SsTx
Authors:Wu, F, Luo, L, Qu, D, Zhang, L, Tian, C, Lai, R.
Deposit date:2017-01-23
Release date:2018-01-24
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Centipedes subdue giant prey by blocking KCNQ channels
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4R8Q
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BU of 4r8q by Molmil
Structure and substrate recruitment of the human spindle checkpoint kinase bub1
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Mitotic checkpoint serine/threonine-protein kinase BUB1
Authors:Tomchick, D.R, Yu, H.
Deposit date:2014-09-02
Release date:2014-11-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structure and substrate recruitment of the human spindle checkpoint kinase Bub1.
Mol.Cell, 32, 2008
2VPF
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BU of 2vpf by Molmil
VASCULAR ENDOTHELIAL GROWTH FACTOR REFINED TO 1.93 ANGSTROMS RESOLUTION
Descriptor: VASCULAR ENDOTHELIAL GROWTH FACTOR
Authors:Muller, Y.A, De Vos, A.M.
Deposit date:1997-07-29
Release date:1998-07-29
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:The crystal structure of vascular endothelial growth factor (VEGF) refined to 1.93 A resolution: multiple copy flexibility and receptor binding.
Structure, 5, 1997
7DC3
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BU of 7dc3 by Molmil
Crystal structure of the MyRF ICA domain
Descriptor: Isoform 2 of Myelin regulatory factor
Authors:Shi, N, Wu, P, Zhen, X.K, Li, B.W.
Deposit date:2020-10-23
Release date:2021-08-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the MyRF ICA domain with its upstream beta-helical stalk reveals the molecular mechanisms underlying its trimerization and self-cleavage.
Int J Biol Sci, 17, 2021
7VD4
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BU of 7vd4 by Molmil
Crystal structure of BPTF-BRD with ligand TP248 bound
Descriptor: 6-[4-[3-(dimethylamino)propoxy]phenyl]-N-methyl-2-methylsulfonyl-pyrimidin-4-amine, Nucleosome-remodeling factor subunit BPTF
Authors:Lu, T, Lu, H.B.
Deposit date:2021-09-06
Release date:2022-09-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.85659146 Å)
Cite:Discovery of a highly potent CECR2 bromodomain inhibitor with 7H-pyrrolo[2,3-d] pyrimidine scaffold.
Bioorg.Chem., 123, 2022
6JTD
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BU of 6jtd by Molmil
Crystal structure of TcCGT1 in complex with UDP
Descriptor: 1,2-ETHANEDIOL, C-glycosyltransferase, URIDINE-5'-DIPHOSPHATE
Authors:Zhao, P, Yun, C.H.
Deposit date:2019-04-10
Release date:2019-06-19
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Molecular and Structural Characterization of a Promiscuous C-Glycosyltransferase from Trollius chinensis.
Angew.Chem.Int.Ed.Engl., 58, 2019
6JPD
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BU of 6jpd by Molmil
Mouse receptor-interacting protein kinase 3 (RIP3) amyloid structure by solid-state NMR
Descriptor: Receptor-interacting serine/threonine-protein kinase 3
Authors:Wu, X.L, Hu, H, Zhang, J, Dong, X.Q, Wang, J, Schwieters, C, Wang, H.Y, Lu, J.X.
Deposit date:2019-03-26
Release date:2020-10-28
Last modified:2024-05-15
Method:SOLID-STATE NMR
Cite:The amyloid structure of mouse RIPK3 (receptor interacting protein kinase 3) in cell necroptosis.
Nat Commun, 12, 2021
6I3N
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BU of 6i3n by Molmil
Helical MyD88 death domain filament
Descriptor: Myeloid differentiation primary response protein MyD88
Authors:Moncrieffe, M.C, Bollschweiler, D, Penczek, P.A.P, Gay, N.J.
Deposit date:2018-11-06
Release date:2019-11-20
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:MyD88 Death-Domain Oligomerization Determines Myddosome Architecture: Implications for Toll-like Receptor Signaling.
Structure, 28, 2020
6KI0
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BU of 6ki0 by Molmil
Crystal Structure of Human ASC-CARD
Descriptor: Maltose/maltodextrin-binding periplasmic protein,Apoptosis-associated speck-like protein containing a CARD, SULFATE ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Xu, Z.H, Jin, T.C.
Deposit date:2019-07-16
Release date:2020-07-22
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Homotypic CARD-CARD interaction is critical for the activation of NLRP1 inflammasome.
Cell Death Dis, 12, 2021
6VHJ
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BU of 6vhj by Molmil
Solution NMR of Prochlorosin 1.1 produced by Prochlorococcus MIT 9313
Descriptor: Prochlorosin 1.1
Authors:Bobeica, S.C, van der Donk, W.A, Tang, W.
Deposit date:2020-01-09
Release date:2020-07-08
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural determinants of macrocyclization in substrate-controlled lanthipeptide biosynthetic pathways.
Chem Sci, 11, 2020
6VJQ
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BU of 6vjq by Molmil
Solution NMR structure of Prochlorosin 2.1 produced by Prochlorococcus MIT 9313
Descriptor: Prochlorosin 2.1
Authors:Bobeica, S.C, van der Donk, W.A, Zhu, L.
Deposit date:2020-01-16
Release date:2020-07-08
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural determinants of macrocyclization in substrate-controlled lanthipeptide biosynthetic pathways.
Chem Sci, 11, 2020
6VLJ
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BU of 6vlj by Molmil
Solution NMR of Prochlorosin 2.8 produced by Prochlorococcus MIT 9313
Descriptor: Prochlorosin 2.8
Authors:Bobeica, S.C, Acedo, J.Z, van der Donk, W.A, Zhu, L.
Deposit date:2020-01-24
Release date:2020-07-08
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural determinants of macrocyclization in substrate-controlled lanthipeptide biosynthetic pathways.
Chem Sci, 11, 2020
7CYF
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BU of 7cyf by Molmil
Cryo-EM structure of bicarbonate transporter SbtA in complex with PII-like signaling protein SbtB from Synechocystis sp. PCC 6803
Descriptor: ADENOSINE MONOPHOSPHATE, Membrane-associated protein slr1513, SODIUM ION, ...
Authors:Liu, X.Y, Jiang, Y.L, Wang, L, Hou, W.T, Chen, Y, Zhou, C.Z.
Deposit date:2020-09-03
Release date:2021-06-23
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3.15 Å)
Cite:Structures of cyanobacterial bicarbonate transporter SbtA and its complex with PII-like SbtB.
Cell Discov, 7, 2021
7CYE
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BU of 7cye by Molmil
Cryo-EM structure of sodium-dependent bicarbonate transporter SbtA from Synechocystis sp. PCC 6803
Descriptor: Slr1512 protein
Authors:Liu, X.Y, Jiang, Y.L, Wang, L, Hou, W.T, Chen, Y, Zhou, C.Z.
Deposit date:2020-09-03
Release date:2021-06-23
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Structures of cyanobacterial bicarbonate transporter SbtA and its complex with PII-like SbtB.
Cell Discov, 7, 2021
7D4B
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BU of 7d4b by Molmil
Crystal structure of 4-1BB in complex with a VHH
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Wang, C.
Deposit date:2020-09-23
Release date:2021-07-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:Generation of a safe and efficacious llama single-domain antibody fragment (vHH) targeting the membrane-proximal region of 4-1BB for engineering therapeutic bispecific antibodies for cancer.
J Immunother Cancer, 9, 2021
7CZD
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BU of 7czd by Molmil
Crystal structure of PD-L1 in complex with a VHH
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Programmed cell death 1 ligand 1, ...
Authors:Wang, C.
Deposit date:2020-09-08
Release date:2021-07-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Generation of a safe and efficacious llama single-domain antibody fragment (vHH) targeting the membrane-proximal region of 4-1BB for engineering therapeutic bispecific antibodies for cancer.
J Immunother Cancer, 9, 2021
1ZV1
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BU of 1zv1 by Molmil
Crystal structure of the dimerization domain of doublesex protein from D. melanogaster
Descriptor: Doublesex protein
Authors:Weiss, M.A, Bayrer, J.R, Wan, Z, Li, B, Phillips, N.B.
Deposit date:2005-06-01
Release date:2005-08-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Dimerization of doublesex is mediated by a cryptic ubiquitin-associated domain fold: implications for sex-specific gene regulation
J.Biol.Chem., 280, 2005
7D7F
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BU of 7d7f by Molmil
Structure of PKD1L3-CTD/PKD2L1 in calcium-bound state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Polycystic kidney disease 2-like 1 protein, ...
Authors:Su, Q, Shi, Y.G.
Deposit date:2020-10-03
Release date:2021-09-01
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for Ca 2+ activation of the heteromeric PKD1L3/PKD2L1 channel.
Nat Commun, 12, 2021
1YCS
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BU of 1ycs by Molmil
P53-53BP2 COMPLEX
Descriptor: 53BP2, P53, ZINC ION
Authors:Gorina, S, Pavletich, N.P.
Deposit date:1996-09-30
Release date:1997-11-19
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2.
Science, 274, 1996

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