6MHU
| Nucleotide-free Cryo-EM Structure of E.coli LptB2FG Transporter | Descriptor: | (2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-2-[(2~{R},4~{R},5~{R},6~{R})-6-[(1~{R})-1,2-bis(oxidanyl)ethyl]-5-[(2~{S},3~{S},4~{R},5~{R},6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-4-[(2~{R},3~{S},4~{R},5~{S},6~{R})-6-[(1~{S})-2-[(2~{S},3~{S},4~{S},5~{S},6~{R})-6-[(1~{S})-1,2-bis(oxidanyl)ethyl]-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-1-oxidanyl-ethyl]-3,4-bis(oxidanyl)-5-phosphonooxy-oxan-2-yl]oxy-3-oxidanyl-5-phosphonooxy-oxan-2-yl]oxy-2-carboxy-2-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-[[(3~{R})-3-dodecanoyloxytetradecanoyl]amino]-6-[[(2~{R},3~{S},4~{R},5~{R},6~{R})-3-oxidanyl-5-[[(3~{R})-3-oxidanyltetradecanoyl]amino]-4-[(3~{R})-3-oxidanyltetradecanoyl]oxy-6-phosphonooxy-oxan-2-yl]methoxy]-3-phosphonooxy-4-[(3~{R})-3-tetradecanoyloxytetradecanoyl]oxy-oxan-2-yl]methoxy]oxan-4-yl]oxy-4,5-bis(oxidanyl)oxane-2-carboxylic acid, Lipopolysaccharide export system ATP-binding protein LptB, Lipopolysaccharide export system permease protein LptF, ... | Authors: | Orlando, B.J, Li, Y, Liao, M. | Deposit date: | 2018-09-18 | Release date: | 2019-04-03 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural basis of lipopolysaccharide extraction by the LptB2FGC complex. Nature, 567, 2019
|
|
6MI8
| Cryo-EM Structure of vanadate-trapped E.coli LptB2FGC | Descriptor: | ADP ORTHOVANADATE, Lipopolysaccharide export system ATP-binding protein LptB, Lipopolysaccharide export system permease protein LptF, ... | Authors: | Orlando, B.J, Li, Y, Liao, M. | Deposit date: | 2018-09-19 | Release date: | 2019-04-03 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structural basis of lipopolysaccharide extraction by the LptB2FGC complex. Nature, 567, 2019
|
|
3QUY
| Structure of the mouse CD1d-BnNH-GSL-1'-iNKT TCR complex | Descriptor: | (2S,3R,4S,5R,6S)-6-[(2S,3S,4R)-2-(hexacosanoylamino)-3,4-dihydroxy-octadecoxy]-3,4,5-trihydroxy-N-(phenylmethyl)oxane-2-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Li, Y, Girardi, E, Yu, E.D, Zajonc, D.M. | Deposit date: | 2011-02-24 | Release date: | 2011-06-29 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis. Embo J., 30, 2011
|
|
6MHZ
| Vanadate trapped Cryo-EM Structure of E.coli LptB2FG Transporter | Descriptor: | ADP ORTHOVANADATE, Lipopolysaccharide export system ATP-binding protein LptB, Lipopolysaccharide export system permease protein LptF, ... | Authors: | Orlando, B.J, Li, Y, Liao, M. | Deposit date: | 2018-09-18 | Release date: | 2019-04-03 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis of lipopolysaccharide extraction by the LptB2FGC complex. Nature, 567, 2019
|
|
6MI7
| Nucleotide-free Cryo-EM Structure of E.coli LptB2FGC | Descriptor: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, Lipopolysaccharide export system ATP-binding protein LptB, Lipopolysaccharide export system permease protein LptF, ... | Authors: | Orlando, B.J, Li, Y, Liao, M. | Deposit date: | 2018-09-19 | Release date: | 2019-04-03 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural basis of lipopolysaccharide extraction by the LptB2FGC complex. Nature, 567, 2019
|
|
6M62
| |
3QUX
| Structure of the mouse CD1d-alpha-C-GalCer-iNKT TCR complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen-presenting glycoprotein CD1d1, ... | Authors: | Li, Y, Girardi, E, Yu, E.D, Zajonc, D.M. | Deposit date: | 2011-02-24 | Release date: | 2011-06-29 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis. Embo J., 30, 2011
|
|
4IS6
| Crystal structure of HLA-DR4 bound to GP100 peptide | Descriptor: | HLA class II histocompatibility antigen, DR alpha chain, DRB1-4 beta chain, ... | Authors: | Li, Y. | Deposit date: | 2013-01-16 | Release date: | 2013-10-23 | Last modified: | 2013-11-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure-Based Design of Altered MHC Class II-Restricted Peptide Ligands with Heterogeneous Immunogenicity. J.Immunol., 191, 2013
|
|
5V4B
| Crystal structure of the Skp1-FBXW7-DISC1 complex | Descriptor: | DISC1 peptide, F-box/WD repeat-containing protein 7, IMIDAZOLE, ... | Authors: | Li, Y, Baillie, G.S, Hao, B. | Deposit date: | 2017-03-08 | Release date: | 2017-09-20 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system. Mol. Psychiatry, 23, 2018
|
|
5W2J
| Crystal structure of dimeric form of mouse Glutaminase C | Descriptor: | CHLORIDE ION, Glutaminase kidney isoform, mitochondrial, ... | Authors: | Cerione, R.A, Li, Y. | Deposit date: | 2017-06-06 | Release date: | 2018-10-17 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Mechanistic Basis of Glutaminase Activation: A KEY ENZYME THAT PROMOTES GLUTAMINE METABOLISM IN CANCER CELLS. J. Biol. Chem., 291, 2016
|
|
7F3B
| cocrystallization of Escherichia coli dihydrofolate reductase (DHFR) and its pyrrolo[3,2-f]quinazoline inhibitor. | Descriptor: | 7-[(2-fluorophenyl)methyl]pyrrolo[3,2-f]quinazoline-1,3-diamine, Dihydrofolate reductase, GLYCEROL | Authors: | Wang, H, You, X.F, Yang, X.Y, Li, Y, Hong, W. | Deposit date: | 2021-06-16 | Release date: | 2022-04-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | The discovery of 1, 3-diamino-7H-pyrrol[3, 2-f]quinazoline compounds as potent antimicrobial antifolates. Eur.J.Med.Chem., 228, 2022
|
|
4P7I
| Crystal structure of the Merlin FERM/DCAF1 complex | Descriptor: | GLYCEROL, Merlin, Protein VPRBP | Authors: | Wei, Z, Li, Y, Zhang, M. | Deposit date: | 2014-03-27 | Release date: | 2014-04-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis of the binding of Merlin FERM domain to the E3 ubiquitin ligase substrate adaptor DCAF1. J.Biol.Chem., 289, 2014
|
|
4R9V
| Crystal structure of sialyltransferase from photobacterium damselae, residues 113-497 corresponding to the gt-b domain | Descriptor: | CALCIUM ION, Sialyltransferase 0160 | Authors: | Li, Y, Huynh, N, Chen, X, Fisher, A.J. | Deposit date: | 2014-09-08 | Release date: | 2014-12-03 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structures of sialyltransferase from Photobacterium damselae. Febs Lett., 588, 2014
|
|
8JYZ
| Cryo-EM structure of RCD-1 pore from Neurospora crassa | Descriptor: | Gasdermin-like protein rcd-1-1, Gasdermin-like protein rcd-1-2 | Authors: | Hou, Y.J, Sun, Q, Li, Y, Ding, J. | Deposit date: | 2023-07-04 | Release date: | 2024-05-01 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.63 Å) | Cite: | Cleavage-independent activation of ancient eukaryotic gasdermins and structural mechanisms. Science, 384, 2024
|
|
5Y27
| Crystal structure of Se-Met Dpb4-Dpb3 | Descriptor: | DNA polymerase epsilon subunit D, GLYCEROL, Putative transcription factor C16C4.22 | Authors: | Li, Y, Gao, F, Su, M, Zhang, F.B, Chen, Y.H. | Deposit date: | 2017-07-24 | Release date: | 2018-01-24 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Coordinated regulation of heterochromatin inheritance by Dpb3-Dpb4 complex. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|
8GJX
| Structure of the human STING receptor bound to 2'3'-cUA | Descriptor: | 2'3'-cUA, Stimulator of interferon genes protein | Authors: | Morehouse, B.R, Li, Y, Slavik, K.M, Toyoda, H, Kranzusch, P.J. | Deposit date: | 2023-03-16 | Release date: | 2023-07-05 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | cGLRs are a diverse family of pattern recognition receptors in innate immunity. Cell, 186, 2023
|
|
7E74
| |
7X8B
| |
7X8F
| |
7X8G
| |
7W6A
| Crystal structure of the MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L complex | Descriptor: | Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, S-ADENOSYL-L-HOMOCYSTEINE, ... | Authors: | Zhao, L, Li, Y, Chen, Y. | Deposit date: | 2021-12-01 | Release date: | 2022-09-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Structural basis for product specificities of MLL family methyltransferases. Mol.Cell, 82, 2022
|
|
7W6I
| The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me1 peptide | Descriptor: | Histone H3.3C, Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, ... | Authors: | Zhao, L, Li, Y, Chen, Y. | Deposit date: | 2021-12-01 | Release date: | 2022-09-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Structural basis for product specificities of MLL family methyltransferases. Mol.Cell, 82, 2022
|
|
7W6L
| The crystal structure of MLL3-RBBP5-ASH2L in complex with H3K4me0 peptide | Descriptor: | Histone H3.3C, Histone-lysine N-methyltransferase 2C, Retinoblastoma-binding protein 5, ... | Authors: | Zhao, L, Li, Y, Chen, Y. | Deposit date: | 2021-12-01 | Release date: | 2022-09-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Structural basis for product specificities of MLL family methyltransferases. Mol.Cell, 82, 2022
|
|
7W67
| The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me0 peptide | Descriptor: | Histone H3.3C, Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, ... | Authors: | Zhao, L, Li, Y, Chen, Y. | Deposit date: | 2021-12-01 | Release date: | 2022-09-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.194 Å) | Cite: | Structural basis for product specificities of MLL family methyltransferases. Mol.Cell, 82, 2022
|
|
7W6J
| The crystal structure of MLL1 (N3861I/Q3867L/C3882SS)-RBBP5-ASH2L in complex with H3K4me2 peptide | Descriptor: | Histone H3.3C, Histone-lysine N-methyltransferase 2A, Retinoblastoma-binding protein 5, ... | Authors: | Zhao, L, Li, Y, Chen, Y. | Deposit date: | 2021-12-01 | Release date: | 2022-09-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | Structural basis for product specificities of MLL family methyltransferases. Mol.Cell, 82, 2022
|
|