4IS6
Crystal structure of HLA-DR4 bound to GP100 peptide
Summary for 4IS6
Entry DOI | 10.2210/pdb4is6/pdb |
Descriptor | HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1-4 beta chain, Melanocyte protein PMEL, ... (4 entities in total) |
Functional Keywords | mhc class ii, hla-dr4, gp100, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane; Single-pass type I membrane protein: P01903 P13760 Endoplasmic reticulum membrane; Single-pass type I membrane protein. M-alpha: Secreted: P40967 |
Total number of polymer chains | 3 |
Total formula weight | 45783.21 |
Authors | |
Primary citation | Chen, S.,Li, Y.,Depontieu, F.R.,McMiller, T.L.,English, A.M.,Shabanowitz, J.,Kos, F.,Sidney, J.,Sette, A.,Rosenberg, S.A.,Hunt, D.F.,Mariuzza, R.A.,Topalian, S.L. Structure-Based Design of Altered MHC Class II-Restricted Peptide Ligands with Heterogeneous Immunogenicity. J.Immunol., 191:5097-5106, 2013 Cited by PubMed: 24108701DOI: 10.4049/jimmunol.1300467 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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