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5V3Y
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BU of 5v3y by Molmil
Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor TAM16
Descriptor: 2-(4-hydroxyphenyl)-~{N}-methyl-5-oxidanyl-4-(piperidin-1-ylmethyl)-1-benzofuran-3-carboxamide, Polyketide synthase Pks13 (Termination polyketide synthase), SULFATE ION
Authors:Aggarwal, A, Sacchettini, J.C.
Deposit date:2017-03-08
Release date:2017-07-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
Cell, 170, 2017
4JAT
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BU of 4jat by Molmil
Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones
Descriptor: Alpha-pyrone synthesis polyketide synthase-like Pks11, PALMITIC ACID
Authors:Gokulan, K, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2013-02-19
Release date:2013-04-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones.
J.Biol.Chem., 288, 2013
5V3Z
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BU of 5v3z by Molmil
Crystal Structure of the D1607N mutant form of Thioesterase domain of Mtb Pks13
Descriptor: PENTAETHYLENE GLYCOL, Polyketide synthase Pks13 (Termination polyketide synthase), SULFATE ION
Authors:Aggarwal, A, Sacchettini, J.C.
Deposit date:2017-03-08
Release date:2017-07-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.881 Å)
Cite:Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
Cell, 170, 2017
5V41
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BU of 5v41 by Molmil
Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor TAM5
Descriptor: Polyketide synthase Pks13 (Termination polyketide synthase), ethyl 5-hydroxy-4-(morpholin-4-ylmethyl)-2-phenyl-1-benzofuran-3-carboxylate
Authors:Aggarwal, A, Sacchettini, J.C.
Deposit date:2017-03-08
Release date:2017-07-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.051 Å)
Cite:Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
Cell, 170, 2017
4M2X
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BU of 4m2x by Molmil
Mycobacterium tuberculosis dihydrofolate reductase complexed with trimetrexate (TMQ)
Descriptor: ACETATE ION, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Jung, H, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2013-08-05
Release date:2014-11-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Selective inhibitors for dihydrofolate reductase from mycobacterium tuberculosis
To be Published
5V40
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BU of 5v40 by Molmil
Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor TAM6
Descriptor: Polyketide synthase Pks13 (Termination polyketide synthase), ethyl 4-[(dimethylamino)methyl]-5-hydroxy-2-phenyl-1-benzofuran-3-carboxylate
Authors:Aggarwal, A, Sacchettini, J.C.
Deposit date:2017-03-08
Release date:2017-07-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.991 Å)
Cite:Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
Cell, 170, 2017
5V3X
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BU of 5v3x by Molmil
Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor TAM1
Descriptor: Polyketide synthase Pks13 (Termination polyketide synthase), ethyl 5-hydroxy-4-[(4-methylpiperidin-1-yl)methyl]-2-phenyl-1-benzofuran-3-carboxylate
Authors:Aggarwal, A, Sacchettini, J.C.
Deposit date:2017-03-08
Release date:2017-07-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.936 Å)
Cite:Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
Cell, 170, 2017
4JAP
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BU of 4jap by Molmil
Crystal Structure of Mycobacterium tuberculosis PKS11 Reveals Intermediates in the Synthesis of Methyl-branched Alkylpyrones
Descriptor: (2S)-2-methyl-3-oxooctadecanoic acid, Alpha-pyrone synthesis polyketide synthase-like Pks11, COENZYME A, ...
Authors:Gokulan, K, Sacchettini, J.C, Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Deposit date:2013-02-19
Release date:2013-04-24
Last modified:2013-11-27
Method:X-RAY DIFFRACTION (1.833 Å)
Cite:Crystal structure of Mycobacterium tuberculosis polyketide synthase 11 (PKS11) reveals intermediates in the synthesis of methyl-branched alkylpyrones.
J.Biol.Chem., 288, 2013
5V3W
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BU of 5v3w by Molmil
Crystal Structure of the Apo form of Thioesterase domain of Mtb Pks13
Descriptor: (2R)-2-{[(2R)-2-{[(2S)-2-{[(2R)-2-hydroxypropyl]oxy}propyl]oxy}propyl]oxy}propan-1-ol, Polyketide synthase Pks13 (Termination polyketide synthase)
Authors:Aggarwal, A, Sacchettini, J.C.
Deposit date:2017-03-08
Release date:2017-07-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.723 Å)
Cite:Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
Cell, 170, 2017
4KBM
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BU of 4kbm by Molmil
Structure of the Mtb CarD/RNAP Beta subunit B1-B2 domains complex
Descriptor: DNA-directed RNA polymerase subunit beta, RNA polymerase-binding transcription factor CarD
Authors:Gulten, G, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2013-04-23
Release date:2013-10-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1146 Å)
Cite:Structure of the Mtb CarD/RNAP beta-Lobes Complex Reveals the Molecular Basis of Interaction and Presents a Distinct DNA-Binding Domain for Mtb CarD.
Structure, 21, 2013
4IR7
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BU of 4ir7 by Molmil
Crystal Structure of Mtb FadD10 in Complex with Dodecanoyl-AMP
Descriptor: 5'-O-[(S)-(dodecanoyloxy)(hydroxy)phosphoryl]adenosine, Long chain fatty acid CoA ligase FadD10, MAGNESIUM ION
Authors:Liu, Z, Wang, F, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2013-01-14
Release date:2013-05-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of Mycobacterium tuberculosis FadD10 protein reveal a new type of adenylate-forming enzyme.
J.Biol.Chem., 288, 2013
4ISB
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BU of 4isb by Molmil
Crystal Structure of Apo Mtb FadD10
Descriptor: Long chain fatty acid CoA ligase FadD10, SULFATE ION
Authors:Liu, Z, Wang, F, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2013-01-16
Release date:2013-05-08
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structures of Mycobacterium tuberculosis FadD10 protein reveal a new type of adenylate-forming enzyme.
J.Biol.Chem., 288, 2013
3DC2
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BU of 3dc2 by Molmil
Crystal structure of serine bound D-3-phosphoglycerate dehydrogenase from Mycobacterium tuberculosis
Descriptor: D-3-phosphoglycerate dehydrogenase, L(+)-TARTARIC ACID, SERINE
Authors:Dey, S, Sacchettini, J.C.
Deposit date:2008-06-03
Release date:2008-07-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural analysis of substrate and effector binding in Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase
Biochemistry, 47, 2008
3DDN
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BU of 3ddn by Molmil
Crystal structure of hydroxypyruvic acid phosphate bound D-3-phosphoglycerate dehydrogenase in mycobacterium tuberculosis
Descriptor: 2-oxo-3-(phosphonooxy)propanoic acid, D-3-phosphoglycerate dehydrogenase, L(+)-TARTARIC ACID
Authors:Dey, S, Sacchettini, J.C.
Deposit date:2008-06-05
Release date:2008-07-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural analysis of substrate and effector binding in Mycobacterium tuberculosis D-3-phosphoglycerate dehydrogenase
Biochemistry, 47, 2008
3FGN
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BU of 3fgn by Molmil
Crystal structure of dethiobiotin synthetase in Mycobacterium tuberculosis
Descriptor: Dethiobiotin synthetase
Authors:Dey, S, Sacchettini, J.C.
Deposit date:2008-12-08
Release date:2009-06-30
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase .
Biochemistry, 49, 2010
3FMI
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BU of 3fmi by Molmil
Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase complexed with 7-Keto 8-aminopelargonic acid
Descriptor: 7-KETO-8-AMINOPELARGONIC ACID, Dethiobiotin synthetase, SULFATE ION
Authors:Dey, S, Sacchettini, J.C.
Deposit date:2008-12-22
Release date:2009-06-30
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase .
Biochemistry, 49, 2010
3D2T
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BU of 3d2t by Molmil
Human transthyretin (ttr) complexed with diflunisal
Descriptor: 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, Transthyretin
Authors:Palaninathan, S.K, Kelly, J.W, Sacchettini, J.C.
Deposit date:2008-05-08
Release date:2008-05-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis.
J.Med.Chem., 47, 2004
3D7P
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BU of 3d7p by Molmil
Crystal structure of human Transthyretin (TTR) at pH 4.0
Descriptor: Transthyretin
Authors:Palaninathan, S.K, Mohamedmohaideen, N.N, Snee, W.C, Kelly, J.W, Sacchettini, J.C.
Deposit date:2008-05-21
Release date:2008-08-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structural insight into pH-induced conformational changes within the native human transthyretin tetramer.
J.Mol.Biol., 382, 2008
3DU4
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BU of 3du4 by Molmil
Crystal structure of 7-keto-8-aminopelargonic acid bound 7,8-diaminopelargonic acid synthase in bacillus subtilis
Descriptor: 7-KETO-8-AMINOPELARGONIC ACID, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, PYRIDOXAL-5'-PHOSPHATE
Authors:Dey, S, Sacchettini, J.C.
Deposit date:2008-07-16
Release date:2009-06-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase .
Biochemistry, 49, 2010
3FMF
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BU of 3fmf by Molmil
Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase complexed with 7,8 diaminopelargonic acid carbamate
Descriptor: 7-(CARBOXYAMINO)-8-AMINO-NONANOIC ACID, Dethiobiotin synthetase
Authors:Dey, S, Sacchettini, J.C.
Deposit date:2008-12-21
Release date:2009-06-30
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase .
Biochemistry, 49, 2010
3FPA
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BU of 3fpa by Molmil
Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase complexed with dethiobiotin and phosphate
Descriptor: 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, Dethiobiotin synthetase, MAGNESIUM ION, ...
Authors:Dey, S, Sacchettini, J.C.
Deposit date:2009-01-04
Release date:2009-06-30
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase.
Biochemistry, 49, 2010
3DRD
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BU of 3drd by Molmil
Crystal Structure of 7,8 Diaminopelargonic Acid Synthase Apoenzyme in Bacillus subtilis
Descriptor: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase
Authors:Dey, S, Sacchettini, J.C.
Deposit date:2008-07-11
Release date:2009-06-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase .
Biochemistry, 49, 2010
3DHY
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BU of 3dhy by Molmil
Crystal Structures of Mycobacterium tuberculosis S-Adenosyl-L-Homocysteine Hydrolase in Ternary Complex with Substrate and Inhibitors
Descriptor: 5'-S-ethyl-5'-thioadenosine, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Shetty, N.D, Ioerger, T.R, Gokulan, K, Reddy, M.C.M, Owen, J.L, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2008-06-19
Release date:2008-09-09
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.
Protein Sci., 17, 2008
3DOD
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BU of 3dod by Molmil
Crystal Structure of PLP Bound 7,8-Diaminopelargonic Acid Synthase in Bacillus subtilis
Descriptor: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, PYRIDOXAL-5'-PHOSPHATE
Authors:Dey, S, Sacchettini, J.C.
Deposit date:2008-07-03
Release date:2009-06-23
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase .
Biochemistry, 49, 2010
1AIV
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BU of 1aiv by Molmil
APO OVOTRANSFERRIN
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, OVOTRANSFERRIN
Authors:Kurokawa, H, Dewan, J.C, Mikami, B, Sacchettini, J.C, Hirose, M.
Deposit date:1997-04-28
Release date:1998-04-29
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of hen apo-ovotransferrin. Both lobes adopt an open conformation upon loss of iron
J.Biol.Chem., 274, 1999

221051

数据于2024-06-12公开中

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