4M2X

Mycobacterium tuberculosis dihydrofolate reductase complexed with trimetrexate (TMQ)

Summary for 4M2X

• Entry DOI: 10.2210/pdb4m2x/pdb
• Descriptor: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TRIMETREXATE, ... (6 entities in total)
• Functional Keywords: structural genomics, tb structural genomics consortium, tbsgc, reductase, nadph binding, hydride transfer, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 4
• Total formula weight: 77630.41

Authors

Jung, H.,Sacchettini, J.C.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2013-08-05, release date: 2014-11-12, Last modification date: 2024-02-28)

• Primary citation: Jung, H.,Sacchettini, J.C.; Selective inhibitors for dihydrofolate reductase from mycobacterium tuberculosis; To be Published,

Experimental method

X-RAY DIFFRACTION (2.26 Å)