4M2X
Mycobacterium tuberculosis dihydrofolate reductase complexed with trimetrexate (TMQ)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, C, E, G) | Dihydrofolate reductase | polymer | 162 | 17943.3 | 4 | UniProt (P0A546) Pfam (PF00186) UniProt (by SIFTS) (P9WNX1) | Mycobacterium tuberculosis | |
| 2 | DA, E, N, V (G, A, C, E) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 4 | Chemie (NDP) | |||
| 3 | EA, F, O, W (G, A, C, E) | TRIMETREXATE | non-polymer | 370.4 | 4 | Chemie (TMQ) | |||
| 4 | AA, BA, CA, FA, G... (E, G, A, C) | ACETATE ION | non-polymer | 59.0 | 22 | Chemie (ACT) | |||
| 5 | M (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 6 | JA, KA, LA, MA (A, C, E, G) | water | water | 18.0 | 98 | Chemie (HOH) |
Sequence modifications
A, C, E, G: 1 - 159 (UniProt: P0A546)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 71773.1 | |
| Non-Polymers* | Number of molecules | 31 |
| Total formula weight | 5857.3 | |
| All* | Total formula weight | 77630.4 |
