Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase complexed with 7,8 diaminopelargonic acid carbamate

Summary for 3FMF

Related3FGN 3FMI
DescriptorDethiobiotin synthetase, 7-(CARBOXYAMINO)-8-AMINO-NONANOIC ACID (3 entities in total)
Functional Keywordsbiotin biosynthesis, rv1570, dethiobiotin synthetase, biod, ligase, atp-binding, magnesium, nucleotide-binding
Biological sourceMycobacterium tuberculosis
Cellular locationCytoplasm (By similarity) O06620
Total number of polymer chains4
Total molecular weight102256.67
Dey, S.,Sacchettini, J.C. (deposition date: 2008-12-21, release date: 2009-06-30, Last modification date: 2011-07-13)
Primary citation
Dey, S.,Lane, J.M.,Lee, R.E.,Rubin, E.J.,Sacchettini, J.C.
Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase .
Biochemistry, 49:6746-6760, 2010
PubMed: 20565114 (PDB entries with the same primary citation)
DOI: 10.1021/bi902097j
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2358 0.4% 10.0% 4.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-28