3FMF
Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase complexed with 7,8 diaminopelargonic acid carbamate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004141 | molecular_function | dethiobiotin synthase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0009102 | biological_process | biotin biosynthetic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004141 | molecular_function | dethiobiotin synthase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0009102 | biological_process | biotin biosynthetic process |
| B | 0016874 | molecular_function | ligase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004141 | molecular_function | dethiobiotin synthase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0009102 | biological_process | biotin biosynthetic process |
| C | 0016874 | molecular_function | ligase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0004141 | molecular_function | dethiobiotin synthase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0009102 | biological_process | biotin biosynthetic process |
| D | 0016874 | molecular_function | ligase activity |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE DSD A 250 |
| Chain | Residue |
| A | LEU143 |
| B | MET72 |
| B | ALA73 |
| B | ALA110 |
| B | HOH231 |
| A | GLY144 |
| A | THR145 |
| A | LEU146 |
| A | ASN147 |
| A | HOH240 |
| B | LYS37 |
| B | GLN40 |
| B | THR41 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE DSD B 250 |
| Chain | Residue |
| A | LYS37 |
| A | GLN40 |
| A | THR41 |
| A | MET72 |
| A | ALA110 |
| A | VAL115 |
| A | HOH238 |
| B | GLY144 |
| B | THR145 |
| B | LEU146 |
| B | ASN147 |
| B | HOH287 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE DSD C 250 |
| Chain | Residue |
| C | LEU143 |
| C | GLY144 |
| C | THR145 |
| C | LEU146 |
| C | ASN147 |
| C | HOH259 |
| D | LYS37 |
| D | GLN40 |
| D | THR41 |
| D | ALA110 |
| D | VAL115 |
| D | HOH231 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE DSD D 250 |
| Chain | Residue |
| C | LYS37 |
| C | GLN40 |
| C | THR41 |
| C | PRO71 |
| C | MET72 |
| C | ALA73 |
| C | ALA110 |
| C | VAL115 |
| C | HOH241 |
| C | HOH322 |
| D | LEU143 |
| D | GLY144 |
| D | THR145 |
| D | LEU146 |
| D | ASN147 |
| D | HOH232 |
| D | HOH259 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00336 |
| Chain | Residue | Details |
| A | LYS37 | |
| B | LYS37 | |
| C | LYS37 | |
| D | LYS37 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:25801336, ECO:0000269|PubMed:30289406, ECO:0000269|DOI:10.1021/acscatal.8b03475, ECO:0007744|PDB:4WOP, ECO:0007744|PDB:6CVE, ECO:0007744|PDB:6CVF, ECO:0007744|PDB:6E05, ECO:0007744|PDB:6E06 |
| Chain | Residue | Details |
| A | THR11 | |
| A | PRO197 | |
| B | THR11 | |
| B | PRO197 | |
| C | THR11 | |
| C | PRO197 | |
| D | THR11 | |
| D | PRO197 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00336, ECO:0000269|PubMed:20565114, ECO:0000269|PubMed:30289406, ECO:0000269|DOI:10.1021/acscatal.8b03475, ECO:0007744|PDB:3FPA, ECO:0007744|PDB:6CVE, ECO:0007744|PDB:6CVF, ECO:0007744|PDB:6CVV, ECO:0007744|PDB:6CZB, ECO:0007744|PDB:6CZC, ECO:0007744|PDB:6CZD, ECO:0007744|PDB:6CZE, ECO:0007744|PDB:6E05, ECO:0007744|PDB:6E06 |
| Chain | Residue | Details |
| A | THR16 | |
| D | THR16 | |
| D | ASP49 | |
| D | GLU108 | |
| A | ASP49 | |
| A | GLU108 | |
| B | THR16 | |
| B | ASP49 | |
| B | GLU108 | |
| C | THR16 | |
| C | ASP49 | |
| C | GLU108 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20565114, ECO:0000269|DOI:10.1021/acscatal.8b03475, ECO:0007744|PDB:3FMF, ECO:0007744|PDB:3FMI, ECO:0007744|PDB:6CVE |
| Chain | Residue | Details |
| A | LYS37 | |
| B | LYS37 | |
| C | LYS37 | |
| D | LYS37 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00336 |
| Chain | Residue | Details |
| A | THR41 | |
| B | THR41 | |
| C | THR41 | |
| D | THR41 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20565114, ECO:0000269|DOI:10.1021/acscatal.8b03475, ECO:0007744|PDB:3FMF, ECO:0007744|PDB:3FMI, ECO:0007744|PDB:3FPA, ECO:0007744|PDB:6CVE |
| Chain | Residue | Details |
| A | GLY144 | |
| B | GLY144 | |
| C | GLY144 | |
| D | GLY144 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:30289406, ECO:0000269|DOI:10.1021/acscatal.8b03475, ECO:0007744|PDB:6CVE, ECO:0007744|PDB:6CVF, ECO:0007744|PDB:6CVU, ECO:0007744|PDB:6E05, ECO:0007744|PDB:6E06 |
| Chain | Residue | Details |
| A | GLY169 | |
| B | GLY169 | |
| C | GLY169 | |
| D | GLY169 |
