3FPA

Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase complexed with dethiobiotin and phosphate

Summary for 3FPA

Entry DOI	10.2210/pdb3fpa/pdb
Related	3FGN 3FMF 3FMI
Descriptor	Dethiobiotin synthetase, PHOSPHATE ION, 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, ... (5 entities in total)
Functional Keywords	rv1570, biod, ligase, atp-binding, biotin biosynthesis, magnesium, nucleotide-binding
Biological source	Mycobacterium tuberculosis
Cellular location	Cytoplasm (By similarity): O06620
Total number of polymer chains	4
Total formula weight	102827.34
Authors	Dey, S.,Sacchettini, J.C. (deposition date: 2009-01-04, release date: 2009-06-30, Last modification date: 2023-09-06)
Primary citation	Dey, S.,Lane, J.M.,Lee, R.E.,Rubin, E.J.,Sacchettini, J.C. Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase. Biochemistry, 49:6746-6760, 2010 Cited by PubMed: 20565114 DOI: 10.1021/bi902097j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation