3FPA

Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase complexed with dethiobiotin and phosphate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Dethiobiotin synthetase	polymer	251	25331.9	4	UniProt (O06620) Pfam (PF13500) UniProt (by SIFTS) (P9WPQ5)	Mycobacterium tuberculosis	Dethiobiotin synthase, DTB synthetase, DTBS
2	E, F, I, J, M... (A, B, C, D)	PHOSPHATE ION	non-polymer		95.0	8	Chemie (PO4)
3	G, K, O (A, B, C)	6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID	non-polymer		214.3	3	Chemie (DTB)
4	H, L, P, S (A, B, C, D)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
5	T, U, V, W (A, B, C, D)	water	water		18.0	186	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 226 (UniProt: O06620)

PDB	External Database	Details
Met -24	-	expression tag
Gly -23	-	expression tag
Ser -22	-	expression tag
Ser -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
Ser -14	-	expression tag
Ser -13	-	expression tag
Gly -12	-	expression tag
Leu -11	-	expression tag
Gln -10	-	expression tag
Gly -9	-	expression tag
Thr -8	-	expression tag
Glu -7	-	expression tag
Asn -6	-	expression tag
Leu -5	-	expression tag
Tyr -4	-	expression tag
Phe -3	-	expression tag
Gln -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	101327.6
Non-Polymers*	Number of molecules	15
	Total formula weight	1499.8
All*	Total formula weight	102827.3

*Water molecules are not included.