3D2T

Human transthyretin (ttr) complexed with diflunisal

Summary for 3D2T

Entry DOI	10.2210/pdb3d2t/pdb
Related	1BMZ 2B77 2B9A 2F7I
Descriptor	Transthyretin, 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID (3 entities in total)
Functional Keywords	ttr, amyloid, transthyretin, disease mutation, gamma-carboxyglutamic acid, glycoprotein, hormone, polyneuropathy, retinol-binding, secreted, thyroid hormone, transport, vitamin a, hormone-growth factor complex
Biological source	Homo sapiens (Human)
Cellular location	Secreted: P02766
Total number of polymer chains	2
Total formula weight	28055.12
Authors	Palaninathan, S.K.,Kelly, J.W.,Sacchettini, J.C. (deposition date: 2008-05-08, release date: 2008-05-20, Last modification date: 2023-08-30)
Primary citation	Adamski-Werner, S.L.,Palaninathan, S.K.,Sacchettini, J.C.,Kelly, J.W. Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis. J.Med.Chem., 47:355-374, 2004 Cited by PubMed: 14711308 DOI: 10.1021/jm030347n PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation