8ESI
| Bile Salt Hydrolase from B. longum with covalent inhibitor bound | Descriptor: | (1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-1-[(2R)-6-fluoro-5-oxohexan-2-yl]-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-7-yl hydrogen sulfate (non-preferred name), Conjugated bile acid hydrolase | Authors: | Walker, M.E, Lim, L, Redinbo, M.R. | Deposit date: | 2022-10-14 | Release date: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity To Be Published
|
|
8ESG
| Bile Salt Hydrolase B from Lactobacillus gasseri with covalent inhibitor bound | Descriptor: | (1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-1-[(2R)-6-fluoro-5-oxohexan-2-yl]-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-7-yl hydrogen sulfate (non-preferred name), Choloylglycine hydrolase | Authors: | Walker, M.E, Redinbo, M.R. | Deposit date: | 2022-10-14 | Release date: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity To Be Published
|
|
8ETK
| Bile salt hydrolase A from Lactobacillus gasseri bound to covalent probe | Descriptor: | (5R)-5-[(1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-9a,11a-dimethyl-7-(2-{2-[(prop-2-yn-1-yl)oxy]ethoxy}ethoxy)hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]-1-fluorohexan-2-one (non-preferred name), Conjugated bile salt hydrolase, SODIUM ION | Authors: | Walker, M.E, Grundy, M.K, Redinbo, M.R. | Deposit date: | 2022-10-17 | Release date: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity To Be Published
|
|
8ESL
| Bile Salt Hydrolase from a Bacteroidales species with covalent inhibitor bound | Descriptor: | (1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-1-[(2R)-6-fluoro-5-oxohexan-2-yl]-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-7-yl hydrogen sulfate (non-preferred name), Choloylglycine hydrolase | Authors: | Walker, M.E, Redinbo, M.R. | Deposit date: | 2022-10-14 | Release date: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.11 Å) | Cite: | Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity To Be Published
|
|
8ETE
| Bile Salt Hydrolase from B. longum with covalent inhibitor bound | Descriptor: | (5R)-1-fluoro-5-[(1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-7-hydroxy-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]hexan-2-one (non-preferred name), Conjugated bile acid hydrolase | Authors: | Walker, M.E, Redinbo, M.R. | Deposit date: | 2022-10-17 | Release date: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity To Be Published
|
|
8ETF
| Bile Salt Hydrolase B from Lactobacillus gasseri with covalent inhibitor bound | Descriptor: | (5R)-1-fluoro-5-[(1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-7-hydroxy-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]hexan-2-one (non-preferred name), Choloylglycine hydrolase, NICKEL (II) ION | Authors: | Walker, M.E, Redinbo, M.R. | Deposit date: | 2022-10-17 | Release date: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity To Be Published
|
|
8EWT
| Bile salt hydrolase A from Lactobacillus gasseri bound to covalent probe | Descriptor: | (5R)-5-{(1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-9a,11a-dimethyl-7-[(prop-2-yn-1-yl)oxy]hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl}-1-fluorohexan-2-one (non-preferred name), Conjugated bile salt hydrolase, SODIUM ION | Authors: | Walker, M.E, Redinbo, M.R. | Deposit date: | 2022-10-24 | Release date: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity To Be Published
|
|
8W1Q
| Aerobic crystal structure of iron-bound FlcD from Pseudomonas aeruginosa | Descriptor: | FE (II) ION, GLYCEROL, MAGNESIUM ION, ... | Authors: | Walker, M.E, Grove, T.L, Li, B, Redinbo, M.R. | Deposit date: | 2024-02-17 | Release date: | 2024-07-31 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Structural Basis for Methine Excision by a Heme Oxygenase-like Enzyme. Acs Cent.Sci., 10, 2024
|
|
9B9M
| Crystal structure of iron-bound FlcD from Pseudomonas aeruginosa | Descriptor: | FE (II) ION, Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C | Authors: | Walker, M.E, Grove, T.L, Li, B, Redinbo, M.R. | Deposit date: | 2024-04-02 | Release date: | 2024-07-31 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Structural Basis for Methine Excision by a Heme Oxygenase-like Enzyme. Acs Cent.Sci., 10, 2024
|
|
9B9O
| Crystal structure of FlcD from Pseudomonas aeruginosa bond to iron(II) and substrate | Descriptor: | (2R)-2-{[(2Z)-2-(hydroxyimino)ethyl]sulfanyl}butanedioic acid, FE (II) ION, Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C | Authors: | Walker, M.E, Grove, T.L, Li, B, Redinbo, M.R. | Deposit date: | 2024-04-02 | Release date: | 2024-07-31 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Structural Basis for Methine Excision by a Heme Oxygenase-like Enzyme. Acs Cent.Sci., 10, 2024
|
|
9B9N
| Crystal structure of FlcD from Pseudomonas aeruginosa bound to iron (II) and substrate | Descriptor: | (2R)-2-{[(2Z)-2-(hydroxyimino)ethyl]sulfanyl}butanedioic acid, FE (III) ION, Pyrroloquinoline quinone (Coenzyme PQQ) biosynthesis protein C | Authors: | Walker, M.E, Grove, T.L, Li, B, Redinbo, M.R. | Deposit date: | 2024-04-02 | Release date: | 2024-07-31 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Structural Basis for Methine Excision by a Heme Oxygenase-like Enzyme. Acs Cent.Sci., 10, 2024
|
|
7KGZ
| |
7SVH
| Bile Salt Hydrolase B from Lactobacillus gasseri | Descriptor: | Choloylglycine hydrolase, MAGNESIUM ION | Authors: | Walker, M.E, Redinbo, M.R. | Deposit date: | 2021-11-19 | Release date: | 2023-01-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut. Nat Microbiol, 8, 2023
|
|
7SVJ
| Bile Salt Hydrolase from Lactobacillus ingluviei | Descriptor: | CALCIUM ION, Choloylglycine hydrolase, DI(HYDROXYETHYL)ETHER, ... | Authors: | Walker, M.E, Patel, S, Redinbo, M.R. | Deposit date: | 2021-11-19 | Release date: | 2023-01-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.43 Å) | Cite: | Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut. Nat Microbiol, 8, 2023
|
|
7SVI
| |
7SVG
| |
7SVK
| |
7SVE
| |
7SVF
| |
8FAO
| Bile Salt Hydrolase B from Lactobacillus gasseri with covalent inhibitor bound | Descriptor: | (5R)-5-[(1R,3aS,3bR,5aR,7R,9aS,9bS,11S,11aR)-7,11-dihydroxy-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]-1-fluorohexan-2-one (non-preferred name), Choloylglycine hydrolase, NICKEL (II) ION | Authors: | Grundy, M.K, Walker, M.E, Redinbo, M.R. | Deposit date: | 2022-11-28 | Release date: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity To Be Published
|
|
8GEN
| E. eligens beta-glucuronidase bound to UNC10201652-glucuronide | Descriptor: | 8-(4-beta-D-glucopyranuronosylpiperazin-1-yl)-5-(morpholin-4-yl)-1,2,3,4-tetrahydro[1,2,3]triazino[4',5':4,5]thieno[2,3 -c]isoquinoline, Beta-glucuronidase | Authors: | Simpson, J.B, Redinbo, M.R. | Deposit date: | 2023-03-07 | Release date: | 2024-02-14 | Last modified: | 2024-09-04 | Method: | X-RAY DIFFRACTION (2.94 Å) | Cite: | Gut microbial beta-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics. Cell Host Microbe, 32, 2024
|
|
8GEQ
| E. eligens beta-glucuronidase bound to ceritinib-glucuronide | Descriptor: | 4-amino-5-chloro-2-{4-(1-beta-D-glucopyranuronosylpiperidin-4-yl)-5-methyl-2-[(propan-2-yl)oxy]anilino}pyrimidine, Beta-glucuronidase | Authors: | Simpson, J.B, Kowalewski, M.K, Redinbo, M.R. | Deposit date: | 2023-03-07 | Release date: | 2024-02-14 | Last modified: | 2024-09-04 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Gut microbial beta-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics. Cell Host Microbe, 32, 2024
|
|
8GES
| R. hominis 2 beta-glucuronidase bound to UNC10201652-glucuronide | Descriptor: | 8-(4-beta-D-glucopyranuronosylpiperazin-1-yl)-5-(morpholin-4-yl)-1,2,3,4-tetrahydro[1,2,3]triazino[4',5':4,5]thieno[2,3 -c]isoquinoline, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | Authors: | Simpson, J.B, Redinbo, M.R. | Deposit date: | 2023-03-07 | Release date: | 2024-02-14 | Last modified: | 2024-09-04 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Gut microbial beta-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics. Cell Host Microbe, 32, 2024
|
|
8GER
| E. eligens beta-glucuronidase bound to norquetiapine-glucuronide | Descriptor: | 11-(4-beta-D-glucopyranuronosylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine, Beta-glucuronidase | Authors: | Simpson, J.B, Lietzan, A.D, Redinbo, M.R. | Deposit date: | 2023-03-07 | Release date: | 2024-03-20 | Last modified: | 2024-06-26 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Gut microbial beta-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics. Cell Host Microbe, 32, 2024
|
|
8GEO
| E. eligens beta-glucuronidase bound to 3-OH-desloratidine-glucuronide | Descriptor: | 8-chloro-11-(1-beta-D-glucopyranuronosylpiperidin-4-ylidene)-3-hydroxy-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, Beta-glucuronidase, GLYCEROL | Authors: | Simpson, J.B, Redinbo, M.R. | Deposit date: | 2023-03-07 | Release date: | 2024-03-20 | Last modified: | 2024-06-26 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Gut microbial beta-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics. Cell Host Microbe, 32, 2024
|
|