6K7P
| Crystal structure of human AFF4-THD domain | Descriptor: | AF4/FMR2 family member 4 | Authors: | Tang, D, Xue, Y, Li, S, Cheng, W, Duan, J, Wang, J, Qi, S. | Deposit date: | 2019-06-08 | Release date: | 2020-03-11 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural and functional insight into the effect of AFF4 dimerization on activation of HIV-1 proviral transcription. Cell Discov, 6, 2020
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6LT0
| cryo-EM structure of C9ORF72-SMCR8-WDR41 | Descriptor: | Guanine nucleotide exchange C9orf72, Guanine nucleotide exchange protein SMCR8, WD repeat-containing protein 41 | Authors: | Tang, D, Sheng, J, Xu, L, Zhan, X, Yan, C, Qi, S. | Deposit date: | 2020-01-21 | Release date: | 2020-04-15 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cryo-EM structure of C9ORF72-SMCR8-WDR41 reveals the role as a GAP for Rab8a and Rab11a. Proc.Natl.Acad.Sci.USA, 117, 2020
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6KYB
| Crystal structure of Atg18 from Saccharomyces cerevisiae | Descriptor: | Autophagy-related protein 18 | Authors: | Tang, D, Lei, Y, Liao, G, Chen, Q, Xu, L, Lu, K, Qi, S. | Deposit date: | 2019-09-17 | Release date: | 2020-09-09 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The crystal structure of Atg18 reveals a new binding site for Atg2 in Saccharomyces cerevisiae. Cell.Mol.Life Sci., 78, 2021
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8C67
| Crystal structure of Ab25 Fab | Descriptor: | antibody 25 heavy chain, antibody 25 light chain | Authors: | Nyblom, M, Izadi, A, Tang, D, Bahnan, W, Happonen, L, Malmstroem, J, Shannon, O, Malmstroem, L, Nordenfelt, P. | Deposit date: | 2023-01-11 | Release date: | 2024-04-24 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Engineering of IgG1 hinge to the flexible IgG3 hinge enhances immune defense against streptococci To Be Published
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5K5W
| Crystal structure of limiting CO2-inducible protein LCIB | Descriptor: | ZINC ION, limiting CO2-inducible protein LCIB | Authors: | Jin, S, Sun, J, Wunder, T, Tang, D, Mueller-Cajar, O.M, Gao, Y. | Deposit date: | 2016-05-24 | Release date: | 2016-12-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.591 Å) | Cite: | Structural insights into the LCIB protein family reveals a new group of beta-carbonic anhydrases Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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5B5X
| Crystal structure of limiting CO2-inducible protein LCIC | Descriptor: | SULFATE ION, ZINC ION, limiting CO2-inducible protein LCIC | Authors: | Jin, S, Sun, J, Wunder, T, Tang, D, Mueller-Cajar, O.M, Gao, Y. | Deposit date: | 2016-05-24 | Release date: | 2016-12-07 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.511 Å) | Cite: | Structural insights into the LCIB protein family reveals a new group of beta-carbonic anhydrases Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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5B60
| Crystal structure of PtLCIB4 S47R mutant, a homolog of the limiting CO2-inducible protein LCIB | Descriptor: | CHLORIDE ION, PtLCIB4 S47R mutant, ZINC ION | Authors: | Jin, S, Sun, J, Wunder, T, Tang, D, Mueller-Caja, O.M, Gao, Y. | Deposit date: | 2016-05-24 | Release date: | 2016-12-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural insights into the LCIB protein family reveals a new group of beta-carbonic anhydrases Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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5B5Y
| Crystal structure of PtLCIB4, a homolog of the limiting CO2-inducible protein LCIB | Descriptor: | ACETATE ION, PtLCIB4, ZINC ION | Authors: | Jin, S, Sun, J, Wunder, T, Tang, D, Mueller-Cajar, O.M, Gao, Y. | Deposit date: | 2016-05-24 | Release date: | 2016-12-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural insights into the LCIB protein family reveals a new group of beta-carbonic anhydrases Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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5B5Z
| Crystal structure of PtLCIB4 H88A mutant, a homolog of the limiting CO2-inducible protein LCIB | Descriptor: | PtLCIB4 H88A mutant, ZINC ION | Authors: | Jin, S, Sun, J, Wunder, T, Tang, D, Mueller-Caja, O.M, Gao, Y. | Deposit date: | 2016-05-24 | Release date: | 2016-12-07 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural insights into the LCIB protein family reveals a new group of beta-carbonic anhydrases Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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9J1R
| Structure of a triple-helix region of human Collagen type II from Trautec | Descriptor: | SULFATE ION, Triple-helix region of human collagen type II | Authors: | Fan, X, Chu, Y, Zhai, Y, Fu, S, Li, D, Cao, K, Feng, P, Wang, X, Le, H, Tang, D, Zhang, F, Qian, S. | Deposit date: | 2024-08-05 | Release date: | 2024-08-21 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structure of a triple-helix region of human Collagen type II from Trautec To Be Published
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8WIK
| Crystal structure of human FSP1 | Descriptor: | 6-HYDROXY-FLAVIN-ADENINE DINUCLEOTIDE, Ferroptosis suppressor protein 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Feng, S, Huang, X, Tang, D, Qi, S. | Deposit date: | 2023-09-24 | Release date: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The crystal structure of human ferroptosis suppressive protein 1 in complex with flavin adenine dinucleotide and nicotinamide adenine nucleotide. MedComm (2020), 5, 2024
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2IC1
| Crystal Structure of Human Cysteine Dioxygenase in Complex with Substrate Cysteine | Descriptor: | CYSTEINE, Cysteine dioxygenase type 1, FE (II) ION | Authors: | Ye, S, Wu, X, Wei, L, Tang, D, Sun, P, Rao, Z. | Deposit date: | 2006-09-12 | Release date: | 2006-12-05 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | An Insight into the Mechanism of Human Cysteine Dioxygenase: KEY ROLES OF THE THIOETHER-BONDED TYROSINE-CYSTEINE COFACTOR. J.Biol.Chem., 282, 2007
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8H2F
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8HI1
| Streptococcus thermophilus Cas1-Cas2- prespacer ternary complex | Descriptor: | CRISPR-associated endonuclease Cas1, DNA (26-MER), DNA (31-MER), ... | Authors: | Chen, Q, Luo, Y. | Deposit date: | 2022-11-18 | Release date: | 2023-09-13 | Last modified: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3.09 Å) | Cite: | DnaQ mediates directional spacer acquisition in the CRISPR-Cas system by a time-dependent mechanism. Innovation (N Y), 4, 2023
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8H18
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8J4U
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7EI1
| Structure of Pyrococcus furiosus Cas1Cas2 complex | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2 | Authors: | Yu, Y, Chen, Q. | Deposit date: | 2021-03-30 | Release date: | 2021-11-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.9 Å) | Cite: | A distinct structure of Cas1-Cas2 complex provides insights into the mechanism for the longer spacer acquisition in Pyrococcus furiosus. Int.J.Biol.Macromol., 183, 2021
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8P1U
| Structure of divisome complex FtsWIQLB | Descriptor: | Cell division protein FtsB, Cell division protein FtsL, Cell division protein FtsQ, ... | Authors: | Yang, L, Chang, S, Tang, D, Dong, H. | Deposit date: | 2023-05-12 | Release date: | 2024-05-22 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural insights into the activation of the divisome complex FtsWIQLB. Cell Discov, 10, 2024
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7QVK
| NM-02 in complex with HER2-ECD | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, NM-02, Receptor tyrosine-protein kinase erbB-2, ... | Authors: | Cowan, R, Hall, G, Carr, M. | Deposit date: | 2022-01-21 | Release date: | 2023-02-01 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Co-crystallisation and humanisation of an anti-HER2 single-domain antibody as a theranostic tool. Plos One, 18, 2023
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7QDL
| N-TERMINAL BROMODOMAIN OF HUMAN BRD4 with I-BET567 | Descriptor: | (2S,4R)-1-acetyl-4-((5-chloropyrimidin-2-yl)amino)-2-methyl-1,2,3,4-tetrahydroquinoline-6-carboxamide, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 | Authors: | Chung, C. | Deposit date: | 2021-11-27 | Release date: | 2022-12-14 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Design, Synthesis, and Characterization of I-BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate. J.Med.Chem., 65, 2022
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7NP1
| Crystal Structure of the SARS-CoV-2 Receptor Binding Domain in Complex with Antibody ION-360 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoblobulin light chain, Immunoglobulin gamma-1 heavy chain, ... | Authors: | Hall, G, Cowan, R, Carr, M. | Deposit date: | 2021-02-26 | Release date: | 2021-11-17 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses. Front Immunol, 12, 2021
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3DYR
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7BNV
| Crystal Structure of the SARS-CoV-2 Receptor Binding Domain in Complex with Antibody ION-300 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain, Light Chain, ... | Authors: | Hall, G, Cowan, R, Carr, M. | Deposit date: | 2021-01-22 | Release date: | 2021-11-17 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses. Front Immunol, 12, 2021
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7CR6
| Synechocystis Cas1-Cas2/prespacer binary complex | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2 1, DNA (36-MER) | Authors: | Yu, Y, Chen, Q. | Deposit date: | 2020-08-12 | Release date: | 2021-03-31 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.72 Å) | Cite: | Mechanisms of spacer acquisition by sequential assembly of the adaptation module in Synechocystis. Nucleic Acids Res., 49, 2021
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7CR8
| Synechocystis Cas1-Cas2-prespacerL complex | Descriptor: | CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2 1, DNA (36-MER) | Authors: | Yu, Y, Chen, Q. | Deposit date: | 2020-08-12 | Release date: | 2021-03-31 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Mechanisms of spacer acquisition by sequential assembly of the adaptation module in Synechocystis. Nucleic Acids Res., 49, 2021
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