1MBM
| NSP4 proteinase from Equine Arteritis Virus | Descriptor: | chymotrypsin-like serine protease | Authors: | Barrette-Ng, I.H, Ng, K.K.-S, Mark, B.L, van Aken, D, Cherney, M.M, Garen, C, Kolodenko, Y, Gorbalenya, A.E, Snijder, E.J, James, M.N.G. | Deposit date: | 2002-08-03 | Release date: | 2002-10-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of Arterivirus nsp4: the smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole J.Biol.Chem., 277, 2002
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3GZF
| Structure of the C-terminal domain of nsp4 from Feline Coronavirus | Descriptor: | Replicase polyprotein 1ab, SULFATE ION | Authors: | Manolaridis, I, Wojdyla, J.A, Panjikar, S, Snijder, E.J, Gorbalenya, A.E, Coutard, B, Tucker, P.A. | Deposit date: | 2009-04-07 | Release date: | 2009-08-18 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.756 Å) | Cite: | Structure of the C-terminal domain of nsp4 from feline coronavirus Acta Crystallogr.,Sect.D, 65, 2009
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1QZ8
| Crystal structure of SARS coronavirus NSP9 | Descriptor: | SULFATE ION, polyprotein 1ab | Authors: | Egloff, M.P, Ferron, F, Campanacci, V, Longhi, S, Rancurel, C, Dutartre, H, Snijder, E.J, Gorbalenya, A.E, Cambillau, C, Canard, B. | Deposit date: | 2003-09-16 | Release date: | 2004-02-24 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world. Proc.Natl.Acad.Sci.USA, 101, 2004
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3JZT
| Structure of a cubic crystal form of X (ADRP) domain from FCoV with ADP-ribose | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, CHLORIDE ION, SODIUM ION, ... | Authors: | Wojdyla, J.A, Manolaridis, I, Tucker, P.A. | Deposit date: | 2009-09-24 | Release date: | 2010-01-12 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3.91 Å) | Cite: | Structure of the X (ADRP) domain of nsp3 from feline coronavirus Acta Crystallogr.,Sect.D, 65, 2009
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3MP2
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2L8K
| NMR Structure of the Arterivirus nonstructural protein 7 alpha (nsp7 alpha) | Descriptor: | Non-structural protein 7 | Authors: | Conte, M.R, Gaudin, C, Manolaridis, I, Tucker, P.W, Kelly, G. | Deposit date: | 2011-01-19 | Release date: | 2011-07-06 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structure and Genetic Analysis of the Arterivirus Nonstructural Protein 7{alpha}. J.Virol., 85, 2011
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6FV1
| Structure of human coronavirus NL63 main protease in complex with the alpha-ketoamide (S)-N-((S)-4-(benzylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)-2-cinnamamido-4-methylpentanamide (cinnamoyl-leucine-GlnLactam-CO-CO-NH-benzyl) | Descriptor: | (2~{S})-4-methyl-~{N}-[(2~{S},3~{R})-3-oxidanyl-4-oxidanylidene-1-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]-2-[[(~{E})-3-phenylprop-2-enoyl]amino]pentanamide, 3C-like proteinase, DIMETHYL SULFOXIDE, ... | Authors: | Zhang, L, Hilgenfeld, R. | Deposit date: | 2018-02-28 | Release date: | 2019-03-20 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication Structure-based design, synthesis, and activity assessment. J.Med.Chem., 2020
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6FV2
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3EW5
| Structure of the tetragonal crystal form of X (ADRP) domain from FCoV | Descriptor: | CHLORIDE ION, SN-GLYCEROL-1-PHOSPHATE, SULFATE ION, ... | Authors: | Wojdyla, J.A, Manolaridis, I, Tucker, P.A. | Deposit date: | 2008-10-14 | Release date: | 2009-10-27 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure of the X (ADRP) domain of nsp3 from feline coronavirus Acta Crystallogr.,Sect.D, 65, 2009
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3EJF
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3ETI
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3EJG
| Crystal structure of HCoV-229E X-domain | Descriptor: | Non-structural protein 3 | Authors: | Piotrowski, Y, Hansen, G, Hilgenfeld, R. | Deposit date: | 2008-09-18 | Release date: | 2008-09-30 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved property. Protein Sci., 18, 2009
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3EKE
| Crystal structure of IBV X-domain at pH 5.6 | Descriptor: | L(+)-TARTARIC ACID, Non-structural protein 3 | Authors: | Piotrowski, Y, Hansen, G, Hilgenfeld, R. | Deposit date: | 2008-09-19 | Release date: | 2008-09-30 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structures of the X-domains of a Group-1 and a Group-3 coronavirus reveal that ADP-ribose-binding may not be a conserved property. Protein Sci., 18, 2009
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5N19
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5N5O
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5NH0
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4IUM
| Equine arteritis virus papain-like protease 2 (PLP2) covalently bound to ubiquitin | Descriptor: | GLYCEROL, Ubiquitin, ZINC ION, ... | Authors: | Bailey-Elkin, B.A, James, T.W, Mark, B.L. | Deposit date: | 2013-01-21 | Release date: | 2013-02-13 | Last modified: | 2013-03-20 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells. Proc.Natl.Acad.Sci.USA, 110, 2013
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5NFS
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4N0O
| Complex structure of Arterivirus nonstructural protein 10 (helicase) with DNA | Descriptor: | CALCIUM ION, DNA, Replicase polyprotein 1ab, ... | Authors: | Deng, Z, Chen, Z. | Deposit date: | 2013-10-02 | Release date: | 2014-01-08 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase. Nucleic Acids Res., 42, 2014
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4N0N
| Crystal structure of Arterivirus nonstructural protein 10 (helicase) | Descriptor: | MAGNESIUM ION, Replicase polyprotein 1ab, SULFATE ION, ... | Authors: | Deng, Z, Chen, Z. | Deposit date: | 2013-10-02 | Release date: | 2014-01-08 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase. Nucleic Acids Res., 42, 2014
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4REZ
| Crystal structure of the Middle-East respiratory syndrome coronavirus papain-like protease | Descriptor: | ORF1ab protein, S-1,2-PROPANEDIOL, ZINC ION | Authors: | Bailey-Elkin, B.A, Johnson, G.G, Mark, B.L. | Deposit date: | 2014-09-24 | Release date: | 2014-10-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression. J.Biol.Chem., 289, 2014
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4RF1
| Crystal structure of the Middle-East respiratory syndrome coronavirus papain-like protease in complex with ubiquitin (space group P63) | Descriptor: | 3-AMINOPROPANE, ORF1ab protein, S-1,2-PROPANEDIOL, ... | Authors: | Bailey-Elkin, B.A, Johnson, G.G, Mark, B.L. | Deposit date: | 2014-09-24 | Release date: | 2014-10-22 | Last modified: | 2015-01-14 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression. J.Biol.Chem., 289, 2014
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4RF0
| Crystal structure of the Middle-East respiratory syndrome coronavirus papain-like protease in complex with ubiquitin (space group P6522) | Descriptor: | 3-AMINOPROPANE, ORF1ab protein, SULFATE ION, ... | Authors: | Bailey-Elkin, B.A, Johnson, G.G, Mark, B.L. | Deposit date: | 2014-09-24 | Release date: | 2014-10-22 | Last modified: | 2015-01-14 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression. J.Biol.Chem., 289, 2014
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1LVO
| Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, 1,4-DIETHYLENE DIOXIDE, Replicase, ... | Authors: | Anand, K, Palm, G.J, Mesters, J.R, Siddell, S.G, Ziebuhr, J, Hilgenfeld, R. | Deposit date: | 2002-05-29 | Release date: | 2002-07-17 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain. EMBO J., 21, 2002
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