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4O9H
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BU of 4o9h by Molmil
Structure of Interleukin-6 in complex with a Camelid Fab fragment
Descriptor: Heavy Chain of the Camelid Fab fragment 61H7, Interleukin-6, Light Chain of the Camelid Fab fragment 61H7
Authors:Klarenbeek, A, Blanchetot, C, Schragel, G, Sadi, A.S, Ongenae, N, Hemrika, W, Wijdenes, J, Spinelli, S, Desmyter, A, Cambillau, C, Hultberg, A, Kretz-rommel, A, Dreier, T, De haard, H.J.W, Roovers, R.C.
Deposit date:2014-01-02
Release date:2015-04-15
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Combining residues of naturally-occurring Camelid somatic affinity variants yields ultra-potent human therapeutic IL-6 antibodies
To be Published
4R90
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BU of 4r90 by Molmil
Anti CD70 Llama glama Fab 27B3
Descriptor: Anti CD70 Llama glama Fab 27B3 Heavy chain, Anti CD70 Llama glama Fab 27B3 Light chain, CALCIUM ION, ...
Authors:Klarenbeek, A, El Mazouari, K, Desmyter, A, Blanchetot, C, Hultberg, A, Roovers, R.C, Cambillau, C, Spinelli, S, Del-Favero, J, Verrips, T, de Haard, H, Achour, I.
Deposit date:2014-09-03
Release date:2015-06-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.746 Å)
Cite:Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.
MAbs, 7, 2015
4R96
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BU of 4r96 by Molmil
Structure of a Llama Glama Fab 48A2 against human cMet
Descriptor: Llama glama Fab 48A2 against human cMet H chain, Llama glama Fab 48A2 against human cMet L chain
Authors:Klarenbeek, A, El Mazouari, K, Desmyter, A, Blanchetot, C, Hultberg, A, Roovers, R.C, Cambillau, C, Spinelli, S, Del-Favero, J, Verrips, T, de Haard, H, Achour, I.
Deposit date:2014-09-03
Release date:2015-06-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Camelid Ig V genes reveal significant human homology not seen in therapeutic target genes, providing for a powerful therapeutic antibody platform.
MAbs, 7, 2015
8UKW
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BU of 8ukw by Molmil
Crystal structure the extracellular region of the epidermal growth factor receptor variant III (EGFRvIII) at pH 5.0
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, ...
Authors:Stayrook, S.E, Ferguson, K.M.
Deposit date:2023-10-15
Release date:2024-06-12
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structural insights into the role and targeting of EGFRvIII
Structure, 2024
8UKX
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BU of 8ukx by Molmil
Crystal structure the extracellular region of the epidermal growth factor receptor variant III (EGFRvIII) at pH 7.0
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Stayrook, S.E, Ferguson, K.M.
Deposit date:2023-10-15
Release date:2024-06-12
Method:X-RAY DIFFRACTION (3.301 Å)
Cite:Structural insights into the role and targeting of EGFRvIII
Structure, 2024
4KRP
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BU of 4krp by Molmil
Nanobody/VHH domain 9G8 in complex with the extracellular region of EGFR
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cetuximab heavy chain, ...
Authors:Ferguson, K.M, Schmitz, K.R.
Deposit date:2013-05-16
Release date:2013-08-28
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.823 Å)
Cite:Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains.
Structure, 21, 2013
4KRO
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BU of 4kro by Molmil
Nanobody/VHH domain EgA1 in complex with the extracellular region of EGFR
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cetuximab heavy chain, ...
Authors:Ferguson, K.M, Schmitz, K.R.
Deposit date:2013-05-16
Release date:2013-08-28
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.054 Å)
Cite:Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains.
Structure, 21, 2013
4KRN
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BU of 4krn by Molmil
Nanobody/VHH domain EgA1
Descriptor: Nanobody/VHH domain EgA1, SULFATE ION
Authors:Ferguson, K.M, Schmitz, K.R.
Deposit date:2013-05-16
Release date:2013-08-28
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.553 Å)
Cite:Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains.
Structure, 21, 2013
4KRM
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BU of 4krm by Molmil
Nanobody/VHH domain 7D12 in complex with domain III of the extracellular region of EGFR, pH 3.5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, ...
Authors:Ferguson, K.M, Schmitz, K.R.
Deposit date:2013-05-16
Release date:2013-08-28
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.655 Å)
Cite:Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains.
Structure, 21, 2013
4KRL
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BU of 4krl by Molmil
Nanobody/VHH domain 7D12 in complex with domain III of the extracellular region of EGFR, pH 6.0
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Ferguson, K.M, Schmitz, K.R.
Deposit date:2013-05-16
Release date:2013-08-28
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.849 Å)
Cite:Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains.
Structure, 21, 2013

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