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1ETN
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BU of 1etn by Molmil
MOLECULAR STRUCTURE OF THE TOXIC DOMAIN OF HEAT-STABLE ENTEROTOXIN PRODUCED BY A PATHOGENIC STRAIN OF ESCHERICHIA COLI
Descriptor: 5-BETA-MERCAPTOPROPIONATE HEAT-STABLE ENTEROTOXIN
Authors:Sato, T, Shimonishi, Y.
Deposit date:1994-03-15
Release date:1996-01-29
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (0.89 Å)
Cite:Molecular structure of the toxin domain of heat-stable enterotoxin produced by a pathogenic strain of Escherichia coli. A putative binding site for a binding protein on rat intestinal epithelial cell membranes.
J.Biol.Chem., 266, 1991
1ETM
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BU of 1etm by Molmil
STRUCTURAL CHARACTERISTICS FOR BIOLOGICAL ACTIVITY OF HEAT-STABLE ENTEROTOXIN PRODUCED BY ENTEROTOXIGENIC ESCHERICHIA COLI: X-RAY CRYSTALLOGRAPHY OF WEAKLY TOXIC AND NONTOXIC ANALOGS
Descriptor: 5-BETA-MERCAPTOPROPIONATE HEAT-STABLE ENTEROTOXIN
Authors:Sato, T, Shimonishi, Y.
Deposit date:1994-03-15
Release date:1996-01-29
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (0.89 Å)
Cite:Structural characteristics for biological activity of heat-stable enterotoxin produced by enterotoxigenic Escherichia coli: X-ray crystallography of weakly toxic and nontoxic analogs.
Biochemistry, 33, 1994
1ETL
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BU of 1etl by Molmil
STRUCTURAL CHARACTERISTICS FOR BIOLOGICAL ACTIVITY OF HEAT-STABLE ENTEROTOXIN PRODUCED BY ENTEROTOXIGENIC ESCHERICHIA COLI: X-RAY CRYSTALLOGRAPHY OF WEAKLY TOXIC AND NONTOXIC ANALOGS
Descriptor: 5-BETA-MERCAPTOPROPIONATE HEAT-STABLE ENTEROTOXIN
Authors:Sato, T, Shimonishi, Y.
Deposit date:1994-03-15
Release date:1996-01-29
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (0.89 Å)
Cite:Structural characteristics for biological activity of heat-stable enterotoxin produced by enterotoxigenic Escherichia coli: X-ray crystallography of weakly toxic and nontoxic analogs.
Biochemistry, 33, 1994
1X0F
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BU of 1x0f by Molmil
Complex structure of the C-terminal RNA-binding domain of hnRNP D(AUF1) with telomeric DNA
Descriptor: 5'-D(P*TP*AP*GP*G)-3', Heterogeneous nuclear ribonucleoprotein D0
Authors:Enokizono, Y, Konishi, Y, Nagata, K, Ouhashi, K, Uesugi, S, Ishikawa, F, Katahira, M.
Deposit date:2005-03-22
Release date:2005-04-05
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Structure of hnRNP D complexed with single-stranded telomere DNA and unfolding of the quadruplex by heterogeneous nuclear ribonucleoprotein D.
J.Biol.Chem., 280, 2005
1EOJ
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BU of 1eoj by Molmil
Design of P1' and P3' residues of trivalent thrombin inhibitors and their crystal structures
Descriptor: ALPHA THROMBIN, THROMBIN INHIBITOR P798
Authors:Slon-Usakiewicz, J.J, Sivaraman, J, Li, Y, Cygler, M, Konishi, Y.
Deposit date:2000-03-23
Release date:2000-05-03
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Design of P1' and P3' residues of trivalent thrombin inhibitors and their crystal structures.
Biochemistry, 39, 2000
1EOL
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BU of 1eol by Molmil
Design of P1' and P3' residues of trivalent thrombin inhibitors and their crystal structures
Descriptor: ALPHA THROMBIN, THROMBIN INHIBITOR P628
Authors:Slon-Usakiewicz, J.J, Sivaraman, J, Li, Y, Cygler, M, Konishi, Y.
Deposit date:2000-03-23
Release date:2000-05-03
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Design of P1' and P3' residues of trivalent thrombin inhibitors and their crystal structures.
Biochemistry, 39, 2000
1WTB
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BU of 1wtb by Molmil
Complex structure of the C-terminal RNA-binding domain of hnRNP D (AUF1) with telomere DNA
Descriptor: 5'-D(P*TP*AP*GP*G)-3', Heterogeneous nuclear ribonucleoprotein D0
Authors:Enokizono, Y, Konishi, Y, Nagata, K, Ouhashi, K, Uesugi, S, Ishikawa, F, Katahira, M.
Deposit date:2004-11-22
Release date:2005-04-05
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Structure of hnRNP D complexed with single-stranded telomere DNA and unfolding of the quadruplex by heterogeneous nuclear ribonucleoprotein D
J.Biol.Chem., 280, 2005
7VPY
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BU of 7vpy by Molmil
Crystal structure of the neutralizing nanobody P86 against SARS-CoV-2
Descriptor: 1,2-ETHANEDIOL, Nanobody, SULFATE ION
Authors:Maeda, R, Fujita, J, Konishi, Y, Kazuma, Y, Yamazaki, H, Anzai, I, Yamaguchi, K, Kasai, K, Nagata, K, Yamaoka, Y, Miyakawa, K, Ryo, A, Shirakawa, K, Makino, F, Matsuura, Y, Inoue, T, Imura, A, Namba, K, Takaori-Kondo, A.
Deposit date:2021-10-18
Release date:2022-07-20
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A panel of nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants including Omicron.
Commun Biol, 5, 2022
7VQ0
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BU of 7vq0 by Molmil
Cryo-EM structure of the SARS-CoV-2 spike protein (2-up RBD) bound to neutralizing nanobodies P86
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Maeda, R, Fujita, J, Konishi, Y, Kazuma, Y, Yamazaki, H, Anzai, I, Yamaguchi, K, Kasai, K, Nagata, K, Yamaoka, Y, Miyakawa, K, Ryo, A, Shirakawa, K, Makino, F, Matsuura, Y, Inoue, T, Imura, A, Namba, K, Takaori-Kondo, A.
Deposit date:2021-10-18
Release date:2022-07-20
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:A panel of nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants including Omicron.
Commun Biol, 5, 2022
1MHW
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BU of 1mhw by Molmil
Design of non-covalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides
Descriptor: 4-biphenylacetyl-Cys-(D)Arg-Tyr-N-(2-phenylethyl) amide, Cathepsin L
Authors:Chowdhury, S, Sivaraman, J, Wang, J, Devanathan, G, Lachance, P, Qi, H, Menard, R, Lefebvre, J, Konishi, Y, Cygler, M, Sulea, T, Purisima, E.O.
Deposit date:2002-08-21
Release date:2002-12-11
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Design of non-covalent inhibitors of human cathepsin L. From the 96-residue proregion to optimized tripeptides
J.Med.Chem., 45, 2002
6LK1
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BU of 6lk1 by Molmil
Ultrahigh resolution X-ray structure of Ferredoxin I from C. reinhardtii
Descriptor: BENZAMIDINE, FE2/S2 (INORGANIC) CLUSTER, Ferredoxin, ...
Authors:Onishi, Y, Kurisu, G, Tanaka, H.
Deposit date:2019-12-17
Release date:2020-05-27
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (0.9 Å)
Cite:X-ray dose-dependent structural changes of the [2Fe-2S] ferredoxin from Chlamydomonas reinhardtii.
J.Biochem., 167, 2020
6KV0
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BU of 6kv0 by Molmil
Ferredoxin I from C. reinhardtii, high X-ray dose
Descriptor: BENZAMIDINE, CHLORIDE ION, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Onishi, Y, Kurisu, G, Tanaka, H.
Deposit date:2019-09-03
Release date:2020-05-20
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:X-ray dose-dependent structural changes of the [2Fe-2S] ferredoxin from Chlamydomonas reinhardtii.
J.Biochem., 167, 2020
6KUM
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BU of 6kum by Molmil
Ferredoxin I from C. reinhardtii, low X-ray dose
Descriptor: BENZAMIDINE, CHLORIDE ION, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Onishi, Y, Kurisu, G, Tanaka, H.
Deposit date:2019-09-02
Release date:2020-05-20
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:X-ray dose-dependent structural changes of the [2Fe-2S] ferredoxin from Chlamydomonas reinhardtii.
J.Biochem., 167, 2020
5Z5S
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BU of 5z5s by Molmil
Crystal structure of the PPARgamma-LBD complexed with compound 13ab
Descriptor: 3-{[6-(4-chloro-3-fluorophenoxy)-1-methyl-1H-benzimidazol-2-yl]methoxy}benzoic acid, CHLORIDE ION, Peptide from Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, ...
Authors:Matsui, Y, Hanzawa, H.
Deposit date:2018-01-19
Release date:2018-10-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of DS-6930, a potent selective PPAR gamma modulator. Part I: Lead identification.
Bioorg. Med. Chem., 26, 2018
5Z6S
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BU of 5z6s by Molmil
Crystal structure of the PPARgamma-LBD complexed with compound DS-6930
Descriptor: 3-[[6-(3,5-dimethylpyridin-2-yl)oxy-1-methyl-benzimidazol-2-yl]methoxy]benzoic acid, CHLORIDE ION, Peptide from Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, ...
Authors:Matsui, Y, Hanzawa, H.
Deposit date:2018-01-25
Release date:2018-10-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of DS-6930, a potent selective PPAR gamma modulator. Part II: Lead optimization.
Bioorg. Med. Chem., 26, 2018
3AM2
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BU of 3am2 by Molmil
Clostridium perfringens enterotoxin
Descriptor: GLYCEROL, Heat-labile enterotoxin B chain, UNKNOWN ATOM OR ION
Authors:Kitadokoro, K, Nishimura, K, Kamitani, S, Kimura, J, Fukui, A, Abe, H, Horiguchi, Y.
Deposit date:2010-08-12
Release date:2011-04-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Crystal Structure of Clostridium perfringens Enterotoxin Displays Features of {beta}-Pore-forming Toxins
J.Biol.Chem., 286, 2011
1RSM
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BU of 1rsm by Molmil
THE 2-ANGSTROMS RESOLUTION STRUCTURE OF A THERMOSTABLE RIBONUCLEASE A CHEMICALLY CROSS-LINKED BETWEEN LYSINE RESIDUES 7 AND 41
Descriptor: DINITROPHENYLENE, RIBONUCLEASE A
Authors:Weber, P.C, Sheriff, S, Ohlendorf, D.H, Finzel, B.C, Salemme, F.R.
Deposit date:1985-08-27
Release date:1986-01-21
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:The 2-A resolution structure of a thermostable ribonuclease A chemically cross-linked between lysine residues 7 and 41.
Proc.Natl.Acad.Sci.USA, 82, 1985
1HBT
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BU of 1hbt by Molmil
Human alpha-thrombin complexed with a peptidyl pyridinium methyl ketone containing bivalent inhibitor
Descriptor: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), P596 Inhibitor peptide
Authors:Rehse, P.H, Cygler, M.
Deposit date:1995-04-06
Release date:1995-07-10
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of a peptidyl pyridinium methyl ketone inhibitor with thrombin.
Biochemistry, 34, 1995
1IHS
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BU of 1ihs by Molmil
CRYSTAL STRUCTURE OF THE COMPLEX OF HUMAN ALPHA-THROMBIN AND NON-HYDROLYZABLE BIFUNCTIONAL INHIBITORS, HIRUTONIN-2 AND HIRUTONIN-6
Descriptor: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), HIRUTONIN
Authors:Zdanov, A, Cygler, M.
Deposit date:1993-08-04
Release date:1994-01-31
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6.
Proteins, 17, 1993
1IHT
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BU of 1iht by Molmil
CRYSTAL STRUCTURE OF THE COMPLEX OF HUMAN ALPHA-THROMBIN AND NON-HYDROLYZABLE BIFUNCTIONAL INHIBITORS, HIRUTONIN-2 AND HIRUTONIN-6
Descriptor: ALPHA-THROMBIN (LARGE SUBUNIT), ALPHA-THROMBIN (SMALL SUBUNIT), HIRUTONIN-6
Authors:Zdanov, A, Cygler, M.
Deposit date:1993-08-04
Release date:1994-01-31
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6.
Proteins, 17, 1993
1YCP
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BU of 1ycp by Molmil
THE CRYSTAL STRUCTURE OF FIBRINOGEN-AA PEPTIDE 1-23 (F8Y) BOUND TO BOVINE THROMBIN EXPLAINS WHY THE MUTATION OF PHE-8 TO TYROSINE STRONGLY INHIBITS NORMAL CLEAVAGE AT ARGININE-16
Descriptor: ALPHA THROMBIN, EPSILON THROMBIN, FIBRINOPEPTIDE A-ALPHA
Authors:Malkowski, M.G, Edwards, B.F.P.
Deposit date:1997-05-01
Release date:1998-05-06
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of fibrinogen-Aalpha peptide 1-23 (F8Y) bound to bovine thrombin explains why the mutation of Phe-8 to tyrosine strongly inhibits normal cleavage at Arg-16.
Biochem.J., 326, 1997
1UCY
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BU of 1ucy by Molmil
THROMBIN COMPLEXED WITH FIBRINOPEPTIDE A ALPHA (RESIDUES 7-19). THREE COMPLEXES, ONE WITH EPSILON-THROMBIN AND TWO WITH ALPHA-THROMBIN
Descriptor: FIBRINOPEPTIDE A-ALPHA, THROMBIN
Authors:Martin, P, Edwards, B.
Deposit date:1996-08-30
Release date:1997-02-12
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Bovine thrombin complexed with an uncleavable analog of residues 7-19 of fibrinogen A alpha: geometry of the catalytic triad and interactions of the P1', P2', and P3' substrate residues.
Biochemistry, 35, 1996
1MKW
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BU of 1mkw by Molmil
THE CO-CRYSTAL STRUCTURE OF UNLIGANDED BOVINE ALPHA-THROMBIN AND PRETHROMBIN-2: MOVEMENT OF THE YPPW SEGMENT AND ACTIVE SITE RESIDUES UPON LIGAND BINDING
Descriptor: ALPHA-THROMBIN, PRETHROMBIN-2
Authors:Malkowski, M.G, Edwards, B.F.P.
Deposit date:1997-03-13
Release date:1997-07-07
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding.
Protein Sci., 6, 1997
1MKX
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THE CO-CRYSTAL STRUCTURE OF UNLIGANDED BOVINE ALPHA-THROMBIN AND PRETHROMBIN-2: MOVEMENT OF THE YPPW SEGMENT AND ACTIVE SITE RESIDUES UPON LIGAND BINDING
Descriptor: ALPHA-THROMBIN, PRETHROMBIN-2
Authors:Malkowski, M.G, Edwards, B.F.P.
Deposit date:1997-03-13
Release date:1997-07-07
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The co-crystal structure of unliganded bovine alpha-thrombin and prethrombin-2: movement of the Tyr-Pro-Pro-Trp segment and active site residues upon ligand binding.
Protein Sci., 6, 1997

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