2VHF
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![BU of 2vhf by Molmil](/molmil-images/mine/2vhf) | Structure of the CYLD USP domain | Descriptor: | UBIQUITIN CARBOXYL-TERMINAL HYDROLASE CYLD, ZINC ION | Authors: | Komander, D, Lord, C.J, Scheel, H, Swift, S, Hofmann, K, Ashworth, A, Barford, D. | Deposit date: | 2007-11-21 | Release date: | 2008-03-11 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The Structure of the Cyld Usp Domain Explains its Specificity for Lys63-Linked Polyubiquitin and Reveals a B-Box Module Mol.Cell.Biol., 29, 2008
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4UUH
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![BU of 4uuh by Molmil](/molmil-images/mine/4uuh) | X-ray crystal structure of human TNKS in complex with a small molecule inhibitor | Descriptor: | 1,2-ETHANEDIOL, 5-methyl-3-[4-(piperazin-1-ylmethyl)phenyl]isoquinolin-1(2H)-one, GLYCEROL, ... | Authors: | Oliver, A.W, Rajasekaran, M.B, Pearl, L.H. | Deposit date: | 2014-07-28 | Release date: | 2015-07-08 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Design and Discovery of 3-Aryl-5-Substituted-Isoquinolin-1- Ones as Potent and Selective Tankyrase Inhibitors Medchemcommm, 6, 2015
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4UW1
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![BU of 4uw1 by Molmil](/molmil-images/mine/4uw1) | X-ray crystal structure of human TNKS in complex with a small molecule inhibitor | Descriptor: | 1,2-ETHANEDIOL, 3-{4-[(dimethylamino)methyl]phenyl}-5-methoxyisoquinolin-1(2H)-one, GLYCEROL, ... | Authors: | Oliver, A.W, Rajasekaran, M.B, Pearl, L.H. | Deposit date: | 2014-08-08 | Release date: | 2015-07-08 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.37 Å) | Cite: | Design and Discovery of 3-Aryl-5-Substituted-Isoquinolin-1-Ones as Potent and Selective Tankyrase Inhibitors Medchemcommm, 6, 2015
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7S6H
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![BU of 7s6h by Molmil](/molmil-images/mine/7s6h) | Human PARP1 deltaV687-E688 bound to NAD+ analog EB-47 and to a DNA double strand break. | Descriptor: | 1,2-ETHANEDIOL, 2-[4-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]carbonylpiperazin-1-yl]-N-(1-oxidanylidene-2,3-dihydroisoindol-4-yl)ethanamide, DNA (5'-D(*CP*GP*AP*CP*G)-3'), ... | Authors: | Rouleau-Turcotte, E, Pascal, J.M. | Deposit date: | 2021-09-14 | Release date: | 2022-06-29 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery. Mol.Cell, 82, 2022
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7S81
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![BU of 7s81 by Molmil](/molmil-images/mine/7s81) | Structure of human PARP1 domains (Zn1, Zn3, WGR, HD) bound to a DNA double strand break. | Descriptor: | DNA (5'-D(*AP*TP*GP*CP*GP*GP*CP*CP*GP*CP*AP*T)-3'), Poly [ADP-ribose] polymerase 1, ZINC ION | Authors: | Rouleau-Turcotte, E, Pascal, J.M. | Deposit date: | 2021-09-17 | Release date: | 2022-06-29 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery. Mol.Cell, 82, 2022
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7S6M
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![BU of 7s6m by Molmil](/molmil-images/mine/7s6m) | |
7S68
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![BU of 7s68 by Molmil](/molmil-images/mine/7s68) | Structure of human PARP1 domains (Zn1, Zn3, WGR and HD) bound to a DNA double strand break. | Descriptor: | DNA (5'-D(*GP*CP*CP*TP*GP*CP*AP*GP*GP*C)-3'), Fusion of PARP1 zinc fingers 1 and 3 (Zn1, Zn3), ... | Authors: | Rouleau-Turcotte, E, Pascal, J.M. | Deposit date: | 2021-09-13 | Release date: | 2022-06-29 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery. Mol.Cell, 82, 2022
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6NTU
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![BU of 6ntu by Molmil](/molmil-images/mine/6ntu) | |
3EU7
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![BU of 3eu7 by Molmil](/molmil-images/mine/3eu7) | Crystal Structure of a PALB2 / BRCA2 complex | Descriptor: | 19meric peptide from Breast cancer type 2 susceptibility protein, GLYCEROL, Partner and localizer of BRCA2 | Authors: | Oliver, A.W, Pearl, L.H. | Deposit date: | 2008-10-09 | Release date: | 2009-07-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis for recruitment of BRCA2 by PALB2 Embo Rep., 10, 2009
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6VKQ
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![BU of 6vkq by Molmil](/molmil-images/mine/6vkq) | Crystal Structure of human PARP-1 CAT domain bound to inhibitor EB-47 | Descriptor: | 2-[4-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]carbonylpiperazin-1-yl]-N-(1-oxidanylidene-2,3-dihydroisoindol-4-yl)ethanamide, Poly [ADP-ribose] polymerase 1, SULFATE ION | Authors: | Steffen, J.D, Pascal, J.M. | Deposit date: | 2020-01-21 | Release date: | 2020-06-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis for allosteric PARP-1 retention on DNA breaks. Science, 368, 2020
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6VKK
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![BU of 6vkk by Molmil](/molmil-images/mine/6vkk) | |
6VKO
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![BU of 6vko by Molmil](/molmil-images/mine/6vko) | |
4U6A
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![BU of 4u6a by Molmil](/molmil-images/mine/4u6a) | |
2W18
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![BU of 2w18 by Molmil](/molmil-images/mine/2w18) | |