2BAG
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![BU of 2bag by Molmil](/molmil-images/mine/2bag) | 3D Structure of Torpedo californica acetylcholinesterase complexed with Ganstigmine | Descriptor: | 1S,3AS,8AS-TRIMETHYL-1-OXIDO-1,2,3,3A,8,8A-HEXAHYDROPYRROLO[2,3-B]INDOL-5-YL 2-ETHYLPHENYLCARBAMATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lamba, D, Bartolucci, C, Siotto, M, Racchi, M, Villetti, G, Delcanale, M. | Deposit date: | 2005-10-14 | Release date: | 2006-08-29 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Determinants of Torpedo californica Acetylcholinesterase Inhibition by the Novel and Orally Active Carbamate Based Anti-Alzheimer Drug Ganstigmine (CHF-2819) J.Med.Chem., 49, 2006
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3CN9
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3I6M
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![BU of 3i6m by Molmil](/molmil-images/mine/3i6m) | 3D Structure of Torpedo californica acetylcholinesterase complexed with N-piperidinopropyl-galanthamine | Descriptor: | (4aS,6R,8aS)-3-methoxy-11-(3-piperidin-1-ylpropyl)-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Lamba, D, Bartolucci, C. | Deposit date: | 2009-07-07 | Release date: | 2010-01-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Probing Torpedo californica acetylcholinesterase catalytic gorge with two novel bis-functional galanthamine derivatives. J.Med.Chem., 53, 2010
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3I6Z
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![BU of 3i6z by Molmil](/molmil-images/mine/3i6z) | 3D Structure of Torpedo californica acetylcholinesterase complexed with N-saccharinohexyl-galanthamine | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{6-[(4aS,6R,8aS)-6-hydroxy-3-methoxy-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]hexyl}-1 ,2-benzisothiazol-3(2H)-one 1,1-dioxide, ... | Authors: | Lamba, D, Bartolucci, C. | Deposit date: | 2009-07-07 | Release date: | 2010-01-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Probing Torpedo californica acetylcholinesterase catalytic gorge with two novel bis-functional galanthamine derivatives. J.Med.Chem., 53, 2010
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1RTF
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4W63
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![BU of 4w63 by Molmil](/molmil-images/mine/4w63) | TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A TACRINE-BENZOFURAN HYBRID INHIBITOR | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase, ... | Authors: | Pesaresi, A, Samez, S, Lamba, D. | Deposit date: | 2014-08-20 | Release date: | 2015-09-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography. J.Med.Chem., 59, 2016
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1U2C
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3ZV7
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![BU of 3zv7 by Molmil](/molmil-images/mine/3zv7) | Torpedo californica Acetylcholinesterase Inhibition by Bisnorcymserine | Descriptor: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Bartolucci, C, Stojan, J, Greig, N.H, Lamba, D. | Deposit date: | 2011-07-24 | Release date: | 2012-05-23 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Kinetics of Torpedo Californica Acetylcholinesterase Inhibition by Bisnorcymserine and Crystal Structure of the Complex with its Leaving Group. Biochem.J., 444, 2012
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5IH7
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1OCE
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![BU of 1oce by Molmil](/molmil-images/mine/1oce) | ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH MF268 | Descriptor: | ACETYLCHOLINESTERASE, CIS-2,6-DIMETHYLMORPHOLINOOCTYLCARBAMYLESEROLINE | Authors: | Bartolucci, C, Perola, E, Cellai, L, Brufani, M, Lamba, D. | Deposit date: | 1998-06-12 | Release date: | 1999-05-18 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | "Back door" opening implied by the crystal structure of a carbamoylated acetylcholinesterase. Biochemistry, 38, 1999
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4WIQ
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![BU of 4wiq by Molmil](/molmil-images/mine/4wiq) | The structure of Murine alpha-Dystroglycan T190M mutant N-terminal domain. | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Dystroglycan | Authors: | Brancaccio, A, Lamba, D, Cassetta, A, Bozzi, M, Covaceuszach, S, Sciandra, F, Bigotti, M.G. | Deposit date: | 2014-09-26 | Release date: | 2015-05-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | The Structure of the T190M Mutant of Murine alpha-Dystroglycan at High Resolution: Insight into the Molecular Basis of a Primary Dystroglycanopathy. Plos One, 10, 2015
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1ZAN
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![BU of 1zan by Molmil](/molmil-images/mine/1zan) | Crystal structure of anti-NGF AD11 Fab | Descriptor: | CHLORIDE ION, Fab AD11 Heavy Chain, Fab AD11 Light Chain | Authors: | Covaceuszach, S, Cattaneo, A, Cassetta, A, Lamba, D. | Deposit date: | 2005-04-06 | Release date: | 2006-04-04 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Dissecting NGF interactions with TrkA and p75 receptors by structural and functional studies of an anti-NGF neutralizing antibody. J.Mol.Biol., 381, 2008
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3CN7
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1K3B
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![BU of 1k3b by Molmil](/molmil-images/mine/1k3b) | Crystal Structure of Human Dipeptidyl Peptidase I (Cathepsin C): Exclusion Domain Added to an Endopeptidase Framework Creates the Machine for Activation of Granular Serine Proteases | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, SULFATE ION, ... | Authors: | Turk, D, Janjic, V, Stern, I, Podobnik, M, Lamba, D, Dahl, S.W, Lauritzen, C, Pedersen, J, Turk, V, Turk, B. | Deposit date: | 2001-10-02 | Release date: | 2002-04-02 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases. EMBO J., 20, 2001
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4X3C
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4TVK
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![BU of 4tvk by Molmil](/molmil-images/mine/4tvk) | TORPEDO CALIFORNICA ACETYLCHOLINESTERASE IN COMPLEX WITH A CHLOROTACRINE-JUGLONE HYBRID INHIBITOR | Descriptor: | 2-({2-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]ethyl}amino)-5-hydroxynaphthalene-1,4-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Pesaresi, A, Samez, S, Lamba, D. | Deposit date: | 2014-06-27 | Release date: | 2014-10-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Multitarget Drug Design Strategy: Quinone-Tacrine Hybrids Designed To Block Amyloid-beta Aggregation and To Exert Anticholinesterase and Antioxidant Effects. J.Med.Chem., 57, 2014
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1FM4
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![BU of 1fm4 by Molmil](/molmil-images/mine/1fm4) | CRYSTAL STRUCTURE OF THE BIRCH POLLEN ALLERGEN BET V 1L | Descriptor: | (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, MAJOR POLLEN ALLERGEN BET V 1-L | Authors: | Markovic-Housley, Z, Degano, M, Lamba, D, von Roepenack-Lahaye, E, Clemens, S, Susani, M, Ferreira, F, Scheiner, O, Breiteneder, H. | Deposit date: | 2000-08-16 | Release date: | 2002-12-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Crystal Structure of a Hypoallergenic Isoform of the Major Birch Pollen Allergen Bet
v 1 and its Likely Biological Function as a Plant Steroid Carrier J.Mol.Biol., 325, 2003
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1XCK
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![BU of 1xck by Molmil](/molmil-images/mine/1xck) | Crystal structure of apo GroEL | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 60 kDa chaperonin, DI(HYDROXYETHYL)ETHER, ... | Authors: | Bartolucci, C, Lamba, D, Grazulis, S, Manakova, E, Heumann, H. | Deposit date: | 2004-09-02 | Release date: | 2005-10-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.92 Å) | Cite: | Crystal structure of wild-type chaperonin GroEL J.Mol.Biol., 354, 2005
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1QTI
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![BU of 1qti by Molmil](/molmil-images/mine/1qti) | Acetylcholinesterase (E.C.3.1.1.7) | Descriptor: | (-)-GALANTHAMINE, ACETYLCHOLINESTERASE | Authors: | Bartolucci, C, Perola, E, Pilger, C, Fels, G, Lamba, D. | Deposit date: | 1999-06-28 | Release date: | 1999-12-29 | Last modified: | 2021-06-02 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Three-dimensional structure of a complex of galanthamine (Nivalin) with acetylcholinesterase from Torpedo californica: implications for the design of new anti-Alzheimer drugs Proteins, 42, 2001
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1SEQ
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![BU of 1seq by Molmil](/molmil-images/mine/1seq) | Fab MNAC13 | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ISOPROPYL ALCOHOL, Monoclonal Antibody MNAC13, ... | Authors: | Covaceuszach, S, Cattaneo, A, Lamba, D. | Deposit date: | 2004-02-18 | Release date: | 2005-03-01 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Neutralization of NGF-TrkA Receptor Interaction by the Novel Antagonistic anti-TrkA Monoclonal Antibody MNAC13: a Structural Insight Proteins, 58, 2005
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5EI5
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5EHX
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![BU of 5ehx by Molmil](/molmil-images/mine/5ehx) | Crystal structure of MSF-aged Torpedo californica Acetylcholinesterase | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3,6,9,12,15-PENTAOXAHEPTADECAN-1-OL, ... | Authors: | Pesaresi, A, Lamba, D. | Deposit date: | 2015-10-29 | Release date: | 2016-11-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of MSF-aged Torpedo californica Acetylcholinesterase To Be Published
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5NUU
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![BU of 5nuu by Molmil](/molmil-images/mine/5nuu) | Torpedo californica acetylcholinesterase in complex with a chlorotacrine-tryptophan hybrid inhibitor | Descriptor: | (2~{S})-2-azanyl-~{N}-[6-[(6-chloranyl-1,2,3,4-tetrahydroacridin-9-yl)amino]hexyl]-3-(1~{H}-indol-3-yl)propanamide, Acetylcholinesterase, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Caliandro, R, Pesaresi, A, Lamba, D. | Deposit date: | 2017-05-02 | Release date: | 2018-05-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease. Eur.J.Med.Chem., 168, 2019
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2HYP
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![BU of 2hyp by Molmil](/molmil-images/mine/2hyp) | Crystal structure of Rv0805 D66A mutant | Descriptor: | BROMIDE ION, CACODYLATE ION, FE (III) ION, ... | Authors: | Shenoy, A.R, Capuder, M, Draskovic, P, Lamba, D, Visweswariah, S.S, Podobnik, M. | Deposit date: | 2006-08-07 | Release date: | 2006-12-26 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural and Biochemical Analysis of the Rv0805 Cyclic Nucleotide Phosphodiesterase from Mycobacterium tuberculosis. J.Mol.Biol., 365, 2007
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2HYO
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![BU of 2hyo by Molmil](/molmil-images/mine/2hyo) | Crystal structure of Rv0805 N97A mutant | Descriptor: | FE (III) ION, MANGANESE (II) ION, Rv0805N97A | Authors: | Shenoy, A.R, Capuder, M, Draskovic, P, Lamba, D, Visweswariah, S.S, Podobnik, M. | Deposit date: | 2006-08-07 | Release date: | 2006-12-26 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural and Biochemical Analysis of the Rv0805 Cyclic Nucleotide Phosphodiesterase from Mycobacterium tuberculosis. J.Mol.Biol., 365, 2007
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