5NUU

Torpedo californica acetylcholinesterase in complex with a chlorotacrine-tryptophan hybrid inhibitor

Summary for 5NUU

• Entry DOI: 10.2210/pdb5nuu/pdb
• Descriptor: Acetylcholinesterase, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: alzheimer's disease, tacrine, acetylcholinesterase, acetylcholiensterase inhibitor, hydrolase
• Biological source: Tetronarce californica (Pacific electric ray)
• Total number of polymer chains: 1
• Total formula weight: 63707.90

Authors

Caliandro, R.,Pesaresi, A.,Lamba, D. (deposition date: 2017-05-02, release date: 2018-05-30, Last modification date: 2024-01-17)

• Primary citation: Chalupova, K.,Korabecny, J.,Bartolini, M.,Monti, B.,Lamba, D.,Caliandro, R.,Pesaresi, A.,Brazzolotto, X.,Gastellier, A.J.,Nachon, F.,Pejchal, J.,Jarosova, M.,Hepnarova, V.,Jun, D.,Hrabinova, M.,Dolezal, R.,Zdarova Karasova, J.,Mzik, M.,Kristofikova, Z.,Misik, J.,Muckova, L.,Jost, P.,Soukup, O.,Benkova, M.,Setnicka, V.,Habartova, L.,Chvojkova, M.,Kleteckova, L.,Vales, K.,Mezeiova, E.,Uliassi, E.,Valis, M.,Nepovimova, E.,Bolognesi, M.L.,Kuca, K.; Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.; Eur.J.Med.Chem., 168:491-514, 2019; PubMed: 30851693; DOI: 10.1016/j.ejmech.2019.02.021

Experimental method

X-RAY DIFFRACTION (2.5 Å)