4WIQ

The structure of Murine alpha-Dystroglycan T190M mutant N-terminal domain.

Summary for 4WIQ

• Entry DOI: 10.2210/pdb4wiq/pdb
• Related: 1U2C
• Descriptor: Dystroglycan, 1,2-ETHANEDIOL, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: mutant, dystroglycanopathy, structural protein
• Biological source: Mus musculus (Mouse)
• Cellular location: Alpha-dystroglycan: Secreted, extracellular space . Beta-dystroglycan: Cell membrane ; Single-pass type I membrane protein : Q62165
• Total number of polymer chains: 1
• Total formula weight: 28669.06

Authors

Brancaccio, A.,Lamba, D.,Cassetta, A.,Bozzi, M.,Covaceuszach, S.,Sciandra, F.,Bigotti, M.G. (deposition date: 2014-09-26, release date: 2015-05-13, Last modification date: 2024-01-10)

• Primary citation: Bozzi, M.,Cassetta, A.,Covaceuszach, S.,Bigotti, M.G.,Bannister, S.,Hubner, W.,Sciandra, F.,Lamba, D.,Brancaccio, A.; The Structure of the T190M Mutant of Murine alpha-Dystroglycan at High Resolution: Insight into the Molecular Basis of a Primary Dystroglycanopathy.; Plos One, 10:e0124277-e0124277, 2015; PubMed: 25932631; DOI: 10.1371/journal.pone.0124277

Experimental method

X-RAY DIFFRACTION (1.59 Å)