1EZP
 
 | | GLOBAL FOLD OF MALTODEXTRIN BINDING PROTEIN COMPLEXED WITH BETA-CYCLODEXTRIN USING PEPTIDE ORIENTATIONS FROM DIPOLAR COUPLINGS | | Descriptor: | MALTODEXTRIN BINDING PERIPLASMIC PROTEIN | | Authors: | Mueller, G.A, Choy, W.Y, Yang, D, Forman-Kay, J.D, Venters, R.A, Kay, L.E. | | Deposit date: | 2000-05-11 | | Release date: | 2001-05-08 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Global folds of proteins with low densities of NOEs using residual dipolar couplings: application to the 370-residue maltodextrin-binding protein.
J.Mol.Biol., 300, 2000
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8UX1
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5VC7
 | | VCP like ATPase from T. acidophilum (VAT) - conformation 1 | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, VCP-like ATPase | | Authors: | Ripstein, Z.A, Huang, R, Augustyniak, R, Kay, L.E, Rubinstein, J.L. | | Deposit date: | 2017-03-31 | | Release date: | 2017-04-26 | | Last modified: | 2020-01-15 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structure of a AAA+ unfoldase in the process of unfolding substrate.
Elife, 6, 2017
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5VCA
 | | VCP like ATPase from T. acidophilum (VAT)-Substrate bound conformation | | Descriptor: | VCP-like ATPase | | Authors: | Ripstein, Z.A, Huang, R, Augustyniak, R, Kay, L.E, Rubinstein, J.L. | | Deposit date: | 2017-03-31 | | Release date: | 2017-04-26 | | Last modified: | 2020-01-15 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Structure of a AAA+ unfoldase in the process of unfolding substrate.
Elife, 6, 2017
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8URV
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1Y8B
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5G4F
 | | Structure of the ADP-bound VAT complex | | Descriptor: | VCP-LIKE ATPASE | | Authors: | Huang, R, Ripstein, Z.A, Augustyniak, R, Lazniewski, M, Ginalski, K, Kay, L.E, Rubinstein, J.L. | | Deposit date: | 2016-05-12 | | Release date: | 2016-07-27 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (7 Å) | | Cite: | Unfolding the Mechanism of the Aaa+ Unfoldase Vat by a Combined Cryo-Em, Solution NMR Study.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5G4G
 | | Structure of the ATPgS-bound VAT complex | | Descriptor: | VCP-LIKE ATPASE | | Authors: | Huang, R, Ripstein, Z.A, Augustyniak, R, Lazniewski, M, Ginalski, K, Kay, L.E, Rubinstein, J.L. | | Deposit date: | 2016-05-12 | | Release date: | 2016-07-27 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (7.8 Å) | | Cite: | Unfolding the Mechanism of the Aaa+ Unfoldase Vat by a Combined Cryo-Em, Solution NMR Study.
Proc.Natl.Acad.Sci.USA, 113, 2016
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1DDM
 | | SOLUTION STRUCTURE OF THE NUMB PTB DOMAIN COMPLEXED TO A NAK PEPTIDE | | Descriptor: | NUMB ASSOCIATE KINASE, NUMB PROTEIN | | Authors: | Zwahlen, C, Li, S.C, Kay, L.E, Pawson, T, Forman-Kay, J.D. | | Deposit date: | 1999-11-11 | | Release date: | 2000-04-10 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Multiple modes of peptide recognition by the PTB domain of the cell fate determinant Numb.
EMBO J., 19, 2000
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8F1U
 | | Structure of a 24mer DegP cage bound to the client protein hTRF1 | | Descriptor: | Periplasmic serine endoprotease DegP, Telomeric repeat-binding factor 1 | | Authors: | Harkness, R.W, Ripstein, Z.A, Di Trani, J.M, Kay, L.E. | | Deposit date: | 2022-11-06 | | Release date: | 2022-11-23 | | Last modified: | 2023-07-05 | | Method: | ELECTRON MICROSCOPY (13.8 Å) | | Cite: | Flexible Client-Dependent Cages in the Assembly Landscape of the Periplasmic Protease-Chaperone DegP.
J.Am.Chem.Soc., 145, 2023
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8F26
 | | Structure of a 60mer DegP cage bound to the client protein hTRF1 | | Descriptor: | Periplasmic serine endoprotease DegP, Telomeric repeat-binding factor 1 | | Authors: | Harkness, R.W, Ripstein, Z.A, Di Trani, J.M, Kay, L.E. | | Deposit date: | 2022-11-07 | | Release date: | 2022-11-23 | | Last modified: | 2023-07-05 | | Method: | ELECTRON MICROSCOPY (9.7 Å) | | Cite: | Flexible Client-Dependent Cages in the Assembly Landscape of the Periplasmic Protease-Chaperone DegP.
J.Am.Chem.Soc., 145, 2023
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8F21
 | | Structure of a 30mer DegP cage bound to the client protein hTRF1 | | Descriptor: | Periplasmic serine endoprotease DegP, Telomeric repeat-binding factor 1 | | Authors: | Harkness, R.W, Ripstein, Z.A, Di Trani, J.M, Kay, L.E. | | Deposit date: | 2022-11-06 | | Release date: | 2022-11-23 | | Last modified: | 2023-07-05 | | Method: | ELECTRON MICROSCOPY (14.1 Å) | | Cite: | Flexible Client-Dependent Cages in the Assembly Landscape of the Periplasmic Protease-Chaperone DegP.
J.Am.Chem.Soc., 145, 2023
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8F0A
 | | Client-bound structure of a DegP trimer within a 12mer cage | | Descriptor: | Periplasmic serine endoprotease DegP, Telomeric repeat-binding factor 1 | | Authors: | Harkness, R.W, Ripstein, Z.A, Di Trani, J.M, Kay, L.E. | | Deposit date: | 2022-11-02 | | Release date: | 2022-11-23 | | Last modified: | 2023-07-05 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Flexible Client-Dependent Cages in the Assembly Landscape of the Periplasmic Protease-Chaperone DegP.
J.Am.Chem.Soc., 145, 2023
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8F0U
 | | Structure of a 12mer DegP cage bound to the client protein hTRF1 | | Descriptor: | Periplasmic serine endoprotease DegP, Telomeric repeat-binding factor 1 | | Authors: | Harkness, R.W, Ripstein, Z.A, Di Trani, J.M, Kay, L.E. | | Deposit date: | 2022-11-04 | | Release date: | 2022-11-23 | | Last modified: | 2023-07-05 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Flexible Client-Dependent Cages in the Assembly Landscape of the Periplasmic Protease-Chaperone DegP.
J.Am.Chem.Soc., 145, 2023
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8F1T
 | | Structure of an 18mer DegP cage bound to the client protein hTRF1 | | Descriptor: | Periplasmic serine endoprotease DegP, Telomeric repeat-binding factor 1 | | Authors: | Harkness, R.W, Ripstein, Z.A, Di Trani, J.M, Kay, L.E. | | Deposit date: | 2022-11-06 | | Release date: | 2022-11-23 | | Last modified: | 2023-07-05 | | Method: | ELECTRON MICROSCOPY (12.1 Å) | | Cite: | Flexible Client-Dependent Cages in the Assembly Landscape of the Periplasmic Protease-Chaperone DegP.
J.Am.Chem.Soc., 145, 2023
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2JQX
 | | Solution structure of Malate Synthase G from joint refinement against NMR and SAXS data | | Descriptor: | Malate synthase G | | Authors: | Grishaev, A, Tugarinov, V, Kay, L.E, Trewhella, J, Bax, A. | | Deposit date: | 2007-06-13 | | Release date: | 2007-07-10 | | Last modified: | 2023-12-20 | | Method: | SOLUTION NMR | | Cite: | Refined solution structure of the 82-kDa enzyme malate synthase G from joint NMR and synchrotron SAXS restraints
J.Biomol.Nmr, 40, 2008
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2KIS
 | | Solution structure of CA150 FF1 domain and FF1-FF2 interdomain linker | | Descriptor: | Transcription elongation regulator 1 | | Authors: | Murphy, J.M, Hansen, D, Wiesner, S, Muhandiram, D, Borg, M, Smith, M.J, Sicheri, F, Kay, L.E, Forman-Kay, J.D, Pawson, T. | | Deposit date: | 2009-05-08 | | Release date: | 2009-09-08 | | Last modified: | 2024-05-08 | | Method: | SOLUTION NMR | | Cite: | Structural studies of FF domains of the transcription factor CA150 provide insights into the organization of FF domain tandem arrays.
J.Mol.Biol., 393, 2009
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6DKF
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6VGQ
 | | ClpP1P2 complex from M. tuberculosis with GLF-CMK bound to ClpP1 | | Descriptor: | ATP-dependent Clp protease proteolytic subunit, ATP-dependent Clp protease proteolytic subunit 1, Z-Gly-leu-phe-CH2Cl | | Authors: | Ripstein, Z.A, Vahidi, S, Rubinstein, J.L, Kay, L.E. | | Deposit date: | 2020-01-08 | | Release date: | 2020-03-18 | | Last modified: | 2020-04-01 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | An allosteric switch regulatesMycobacterium tuberculosisClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6VGK
 | | ClpP1P2 complex from M. tuberculosis | | Descriptor: | ATP-dependent Clp protease proteolytic subunit 1, ATP-dependent Clp protease proteolytic subunit 2 | | Authors: | Ripstein, Z.A, Vahidi, S, Rubinstein, J.L, Kay, L.E. | | Deposit date: | 2020-01-08 | | Release date: | 2020-03-18 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | An allosteric switch regulatesMycobacterium tuberculosisClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR.
Proc.Natl.Acad.Sci.USA, 117, 2020
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6VFX
 | | ClpXP from Neisseria meningitidis - Conformation B | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ... | | Authors: | Ripstein, Z.A, Vahidi, S, Houry, W.A, Rubinstein, J.L, Kay, L.E. | | Deposit date: | 2020-01-06 | | Release date: | 2020-01-22 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery.
Elife, 9, 2020
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6VFS
 | | ClpXP from Neisseria meningitidis - Conformation A | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ... | | Authors: | Ripstein, Z.A, Vahidi, S, Houry, W.A, Rubinstein, J.L, Kay, L.E. | | Deposit date: | 2020-01-06 | | Release date: | 2020-01-22 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery.
Elife, 9, 2020
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6VGN
 | | ClpP1P2 complex from M. tuberculosis bound to ADEP | | Descriptor: | ATP-dependent Clp protease proteolytic subunit, ATP-dependent Clp protease proteolytic subunit 1, R0M-WFP-ALO-PRO-YCP-ALA-MP8 | | Authors: | Ripstein, Z.A, Vahidi, S, Rubinstein, J.L, Kay, L.E. | | Deposit date: | 2020-01-08 | | Release date: | 2020-03-18 | | Last modified: | 2020-04-01 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | An allosteric switch regulatesMycobacterium tuberculosisClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR.
Proc.Natl.Acad.Sci.USA, 117, 2020
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1KA7
 | | SAP/SH2D1A bound to peptide n-Y-c | | Descriptor: | SH2 DOMAIN PROTEIN 1A, peptide n-Y-c | | Authors: | Hwang, P.M, Li, C, Morra, M, Lillywhite, J, Gertler, F, Terhorst, C, Kay, L.E, Pawson, T, Forman-Kay, J, Li, S.-C. | | Deposit date: | 2001-10-31 | | Release date: | 2001-11-07 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome.
EMBO J., 21, 2002
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1KA6
 | | SAP/SH2D1A bound to peptide n-pY | | Descriptor: | SH2 DOMAIN PROTEIN 1A, peptide n-pY | | Authors: | Hwang, P.M, Li, C, Morra, M, Lillywhite, J, Gertler, F, Terhorst, C, Kay, L.E, Pawson, T, Forman-Kay, J, Li, S.-C. | | Deposit date: | 2001-10-31 | | Release date: | 2001-11-07 | | Last modified: | 2021-10-27 | | Method: | SOLUTION NMR | | Cite: | A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome.
EMBO J., 21, 2002
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