8RH7
 
 | | CryoEM structure of human rho1 GABAA receptor in complex with GABA and estradiol in primed state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ESTRADIOL, ... | | Authors: | Chen, F, John, C, Rebecca, J.H, Erik, L. | | Deposit date: | 2023-12-15 | | Release date: | 2024-08-28 | | Method: | ELECTRON MICROSCOPY (2.78 Å) | | Cite: | Divergent mechanisms of steroid inhibition in the human rho1 GABAA receptor
Nat Commun, 2024
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8RHG
 | | CryoEM structure of human rho1 GABAA receptor in complex with GABA and pregnenolone sulfate | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GAMMA-AMINO-BUTANOIC ACID, ... | | Authors: | Chen, F, John, C, Rebecca, J.H, Erik, L. | | Deposit date: | 2023-12-15 | | Release date: | 2024-08-28 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Divergent mechanisms of steroid inhibition in the human rho1 GABAA receptor
Nat Commun, 2024
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8RH9
 | | CryoEM structure of human rho1 GABAA receptor in complex with pregnenolone sulfate | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, DECANE, ... | | Authors: | Chen, F, John, C, Rebecca, J.H, Erik, L. | | Deposit date: | 2023-12-15 | | Release date: | 2024-08-28 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | Divergent mechanisms of steroid inhibition in the human rho1 GABAA receptor
Nat Commun, 2024
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8RH4
 | | CryoEM structure of human rho1 GABAA receptor in complex with estradiol | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, DECANE, ... | | Authors: | Chen, F, John, C, Rebecca, J.H, Erik, L. | | Deposit date: | 2023-12-14 | | Release date: | 2024-08-28 | | Method: | ELECTRON MICROSCOPY (2.52 Å) | | Cite: | Divergent mechanisms of steroid inhibition in the human rho1 GABAA receptor
Nat Commun, 2024
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8RH8
 | | CryoEM structure of human rho1 GABAA receptor in complex with GABA and estradiol in desensitized state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GAMMA-AMINO-BUTANOIC ACID, ... | | Authors: | Chen, F, John, C, Rebecca, J.H, Erik, L. | | Deposit date: | 2023-12-15 | | Release date: | 2024-08-28 | | Method: | ELECTRON MICROSCOPY (2.66 Å) | | Cite: | Divergent mechanisms of steroid inhibition in the human rho1 GABAA receptor
Nat Commun, 2024
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4S1Z
 | | Crystal structure of TRABID NZF1 in complex with K29 linked di-Ubiquitin | | Descriptor: | Ubiquitin, Ubiquitin thioesterase ZRANB1, ZINC ION | | Authors: | Kristariyanto, Y.A, Abdul Rehman, S.A, Campbell, D.G, Morrice, N.A, Johnson, C, Toth, R, Kulathu, Y. | | Deposit date: | 2015-01-16 | | Release date: | 2015-04-08 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (3.03 Å) | | Cite: | K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of k29 polyubiquitin.
Mol.Cell, 58, 2015
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4S22
 | | Crystal structure of K29 linked di-Ubiquitin | | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, IODIDE ION, ... | | Authors: | Kristariyanto, Y.A, Abdul Rehman, S.A, Campbell, D.G, Morrice, N.A, Johnson, C, Toth, R, Kulathu, Y. | | Deposit date: | 2015-01-17 | | Release date: | 2015-04-08 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of k29 polyubiquitin.
Mol.Cell, 58, 2015
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5N2W
 | | WT-Parkin and pUB complex | | Descriptor: | CHLORIDE ION, E3 ubiquitin-protein ligase parkin,E3 ubiquitin-protein ligase parkin, Polyubiquitin-B, ... | | Authors: | Kumar, A, Chaugule, V.K, Johnson, C, Toth, R, Sundaramoorthy, R, Knebel, A, Walden, H. | | Deposit date: | 2017-02-08 | | Release date: | 2017-04-19 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.68 Å) | | Cite: | Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.
Nat. Struct. Mol. Biol., 24, 2017
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5N38
 | | S65DParkin and pUB complex | | Descriptor: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, E3 ubiquitin-protein ligase parkin,E3 ubiquitin-protein ligase parkin, ... | | Authors: | Kumar, A, Chaugule, V.K, Johnson, C, Toth, R, Sundaramoorthy, R, Knebel, A, Walden, H. | | Deposit date: | 2017-02-08 | | Release date: | 2017-04-19 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.
Nat. Struct. Mol. Biol., 24, 2017
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1XGK
 | | CRYSTAL STRUCTURE OF N12G AND A18G MUTANT NMRA | | Descriptor: | CHLORIDE ION, GLYCEROL, NITROGEN METABOLITE REPRESSION REGULATOR NMRA, ... | | Authors: | Lamb, H.K, Ren, J, Park, A, Johnson, C, Leslie, K, Cocklin, S, Thompson, P, Mee, C, Cooper, A, Stammers, D.K, Hawkins, A.R. | | Deposit date: | 2004-09-17 | | Release date: | 2004-12-14 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Modulation of the ligand binding properties of the transcription repressor NmrA by GATA-containing DNA and site-directed mutagenesis
Protein Sci., 13, 2004
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2VUS
 | | Crystal structure of unliganded NmrA-AreA zinc finger complex | | Descriptor: | CHLORIDE ION, NITROGEN METABOLITE REPRESSION REGULATOR NMRA, NITROGEN REGULATORY PROTEIN AREA, ... | | Authors: | Kotaka, M, Johnson, C, Lamb, H.K, Hawkins, A.R, Ren, J, Stammers, D.K. | | Deposit date: | 2008-05-30 | | Release date: | 2008-07-29 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural Analysis of the Recognition of the Negative Regulator Nmra and DNA by the Zinc Finger from the Gata-Type Transcription Factor Area.
J.Mol.Biol., 381, 2008
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2VUT
 | | Crystal structure of NAD-bound NmrA-AreA zinc finger complex | | Descriptor: | CHLORIDE ION, GLYCEROL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | Authors: | Kotaka, M, Johnson, C, Lamb, H.K, Hawkins, A.R, Ren, J, Stammers, D.K. | | Deposit date: | 2008-05-30 | | Release date: | 2008-07-29 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural Analysis of the Recognition of the Negative Regulator Nmra and DNA by the Zinc Finger from the Gata-Type Transcription Factor Area.
J.Mol.Biol., 381, 2008
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2VUU
 | | Crystal structure of NADP-bound NmrA-AreA zinc finger complex | | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NITROGEN METABOLITE REPRESSION REGULATOR NMRA, NITROGEN REGULATORY PROTEIN AREA, ... | | Authors: | Kotaka, M, Johnson, C, Lamb, H.K, Hawkins, A.R, Ren, J, Stammers, D.K. | | Deposit date: | 2008-05-30 | | Release date: | 2008-07-29 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural Analysis of the Recognition of the Negative Regulator Nmra and DNA by the Zinc Finger from the Gata-Type Transcription Factor Area.
J.Mol.Biol., 381, 2008
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1TI7
 | | CRYSTAL STRUCTURE OF NMRA, A NEGATIVE TRANSCRIPTIONAL REGULATOR, IN COMPLEX WITH NADP AT 1.7A RESOLUTION | | Descriptor: | CHLORIDE ION, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | Authors: | Lamb, H.K, Leslie, K, Dodds, A.L, Nutley, M, Cooper, A, Johnson, C, Thompson, P, Stammers, D.K, Hawkins, A.R. | | Deposit date: | 2004-06-02 | | Release date: | 2004-06-08 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | The negative transcriptional regulator NmrA discriminates between oxidized and reduced dinucleotides.
J.Biol.Chem., 278, 2003
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8OQ7
 | | CryoEM structure of human rho1 GABAA receptor in complex with inhibitor TPMPA | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, DECANE, ... | | Authors: | Chen, F, Victor, T, John, C, Rebecca, J.H, Lindahl, E. | | Deposit date: | 2023-04-11 | | Release date: | 2023-08-30 | | Last modified: | 2024-02-07 | | Method: | ELECTRON MICROSCOPY (2.2 Å) | | Cite: | Structure and dynamics of differential ligand binding in the human rho-type GABA A receptor.
Neuron, 111, 2023
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8OQ8
 | | CryoEM structure of human rho1 GABAA receptor in complex with pore blocker picrotoxin | | Descriptor: | (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, DECANE, ... | | Authors: | Chen, F, Victor, T, John, C, Rebecca, J.H, Lindahl, E. | | Deposit date: | 2023-04-11 | | Release date: | 2023-08-30 | | Last modified: | 2024-02-07 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structure and dynamics of differential ligand binding in the human rho-type GABA A receptor.
Neuron, 111, 2023
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8OQA
 | | CryoEM structure of human rho1 GABAA receptor in complex with GABA and picrotoxin | | Descriptor: | (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | Authors: | Chen, F, Victor, T, John, C, Rebecca, J.H, Lindahl, E. | | Deposit date: | 2023-04-11 | | Release date: | 2023-08-30 | | Last modified: | 2024-02-07 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structure and dynamics of differential ligand binding in the human rho-type GABA A receptor.
Neuron, 111, 2023
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8OP9
 | | CryoEM structure of human rho1 GABAA receptor in complex with GABA | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GAMMA-AMINO-BUTANOIC ACID, ... | | Authors: | Chen, F, Victor, T, John, C, Rebecca, J.H, Lindahl, E. | | Deposit date: | 2023-04-06 | | Release date: | 2023-08-30 | | Last modified: | 2024-02-07 | | Method: | ELECTRON MICROSCOPY (3.36 Å) | | Cite: | Structure and dynamics of differential ligand binding in the human rho-type GABA A receptor.
Neuron, 111, 2023
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8OQ6
 | | CryoEM structure of human rho1 GABAA receptor apo state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, DECANE, ... | | Authors: | Chen, F, Victor, T, John, C, Rebecca, J.H, Lindahl, E. | | Deposit date: | 2023-04-11 | | Release date: | 2023-08-30 | | Last modified: | 2024-02-07 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | Structure and dynamics of differential ligand binding in the human rho-type GABA A receptor.
Neuron, 111, 2023
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6MDU
 | | Crystal structure of NDM-1 with compound 7 | | Descriptor: | 1,5-diphenyl-N-(1H-tetrazol-5-yl)-1H-pyrazole-3-carboxamide, GLYCEROL, Metallo-beta-lactamase type 2, ... | | Authors: | Akhtar, A, Chen, Y. | | Deposit date: | 2018-09-05 | | Release date: | 2019-04-17 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.15 Å) | | Cite: | Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery.
Acs Infect Dis., 5, 2019
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8A67
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5UHV
 | | wild-type NRas bound to GppNHp | | Descriptor: | GLYCEROL, GTPase NRas, MAGNESIUM ION, ... | | Authors: | Reid, D, Johnson, C, Salter, S, Mattos, C. | | Deposit date: | 2017-01-12 | | Release date: | 2017-06-28 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.672 Å) | | Cite: | The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects.
J. Biol. Chem., 292, 2017
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7KDT
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8DTX
 | | Crystal structure of SARS-CoV-2 spike stem helix peptide in complex with neutralizing antibody COV89-22 | | Descriptor: | COV89-22 heavy chain, COV89-22 light chain, Spike protein S2' stem helix peptide | | Authors: | Lin, T.H, Lee, C.C.D, Wilson, I.A. | | Deposit date: | 2022-07-26 | | Release date: | 2022-11-23 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses.
Cell Host Microbe, 31, 2023
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8DTR
 | | Crystal structure of SARS-CoV-2 spike stem helix peptide in complex with neutralizing antibody COV30-14 | | Descriptor: | COV30-14 heavy chain, COV30-14 light chain, Spike protein S2' stem helix peptide | | Authors: | Lee, C.C.D, Lin, T.H, Wilson, I.A. | | Deposit date: | 2022-07-26 | | Release date: | 2022-11-23 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses.
Cell Host Microbe, 31, 2023
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