8OQ7

CryoEM structure of human rho1 GABAA receptor in complex with inhibitor TPMPA

Summary for 8OQ7

Entry DOI	10.2210/pdb8oq7/pdb
EMDB information	17107
Descriptor	Gamma-aminobutyric acid receptor subunit rho-1, methyl(1,2,3,6-tetrahydropyridin-4-yl)phosphinic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
Functional Keywords	gabaa receptor, rho1, membrane protein
Biological source	Homo sapiens (human)
Total number of polymer chains	5
Total formula weight	287829.77
Authors	Chen, F.,Victor, T.,John, C.,Rebecca, J.H.,Lindahl, E. (deposition date: 2023-04-11, release date: 2023-08-30, Last modification date: 2024-02-07)
Primary citation	Cowgill, J.,Fan, C.,Haloi, N.,Tobiasson, V.,Zhuang, Y.,Howard, R.J.,Lindahl, E. Structure and dynamics of differential ligand binding in the human rho-type GABA A receptor. Neuron, 111:3450-, 2023 Cited by PubMed: 37659407 DOI: 10.1016/j.neuron.2023.08.006 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.2 Å)

Structure validation