4WMJ
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8BD0
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8BPI
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8Q3L
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1XR3
| Actinorhodin Polyketide Ketoreductase with NADP and the Inhibitor Isoniazid bound | Descriptor: | 4-(DIAZENYLCARBONYL)PYRIDINE, ACTINORHODIN POLYKETIDE KETOREDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Korman, T.P, Hill, J.A, Vu, T.N, Tsai, S.C. | Deposit date: | 2004-10-13 | Release date: | 2005-09-27 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity. Biochemistry, 43, 2004
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1X7G
| Actinorhodin Polyketide Ketoreductase, act KR, with NADP bound | Descriptor: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Putative ketoacyl reductase | Authors: | Korman, T.P, Hill, J.A, Vu, T.N. | Deposit date: | 2004-08-13 | Release date: | 2004-12-14 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity Biochemistry, 43, 2004
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1X7H
| Actinorhodin Polyketide Ketoreductase, with NADPH bound | Descriptor: | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Putative ketoacyl reductase | Authors: | Korman, T.P, Hill, J.A, Vu, T.N. | Deposit date: | 2004-08-13 | Release date: | 2004-12-14 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity Biochemistry, 43, 2004
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7ZXK
| Human IL-27 in complex with neutralizing SRF388 FAb fragment | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-27 subunit alpha, Interleukin-27 subunit beta, ... | Authors: | Bloch, Y, Skladanowska, K, Strand, J, Welin, M, Logan, D, Hill, J, Savvides, S.N. | Deposit date: | 2022-05-21 | Release date: | 2022-11-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27. Cell Rep, 41, 2022
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7ZG0
| Murine IL-27 in complex with IL-27Ra and a non-competing Nb | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-27 receptor subunit alpha, ... | Authors: | Skladanowska, K, Bloch, Y, Savvides, S.N. | Deposit date: | 2022-04-01 | Release date: | 2022-11-02 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (3.18 Å) | Cite: | Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27. Cell Rep, 41, 2022
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7LCU
| X-ray structure of Furin bound to BOS-318, a small molecule inhibitor | Descriptor: | (1-{[2-(3,5-dichlorophenyl)-6-{[2-(4-methylpiperazin-1-yl)pyrimidin-5-yl]oxy}pyridin-4-yl]methyl}piperidin-4-yl)acetic acid, 1,2-ETHANEDIOL, CALCIUM ION, ... | Authors: | Campobasso, N, Reid, R. | Deposit date: | 2021-01-11 | Release date: | 2022-01-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.24 Å) | Cite: | A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease. Cell Chem Biol, 29, 2022
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