1W4R
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![BU of 1w4r by Molmil](/molmil-images/mine/1w4r) | Structure of a type II thymidine kinase with bound dTTP | Descriptor: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, THYMIDINE KINASE, THYMIDINE-5'-TRIPHOSPHATE, ... | Authors: | Birringer, M.S, Claus, M.T, Folkers, G, Kloer, D.P, Schulz, G.E, Scapozza, L. | Deposit date: | 2004-07-27 | Release date: | 2005-02-01 | Last modified: | 2013-03-06 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Structure of a Type II Thymidine Kinase with Bound Dttp FEBS Lett., 579, 2005
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1Z6B
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![BU of 1z6b by Molmil](/molmil-images/mine/1z6b) | Crystal structure of Plasmodium falciparum FabZ at 2.1 A | Descriptor: | CACODYLATE ION, CHLORIDE ION, SULFATE ION, ... | Authors: | Kostrewa, D, Winkler, F.K, Folkers, G, Scapozza, L, Perozzo, R. | Deposit date: | 2005-03-22 | Release date: | 2005-06-14 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | The crystal structure of PfFabZ, the unique beta-hydroxyacyl-ACP dehydratase involved in fatty acid biosynthesis of Plasmodium falciparum PROTEIN SCI., 14, 2005
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1Z00
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![BU of 1z00 by Molmil](/molmil-images/mine/1z00) | Solution structure of the C-terminal domain of ERCC1 complexed with the C-terminal domain of XPF | Descriptor: | DNA excision repair protein ERCC-1, DNA repair endonuclease XPF | Authors: | Tripsianes, K, Folkers, G, Ab, E, Das, D, Odijk, H, Jaspers, N.G.J, Hoeijmakers, J.H.J, Kaptein, R, Boelens, R. | Deposit date: | 2005-03-01 | Release date: | 2005-12-20 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | The Structure of the Human ERCC1/XPF Interaction Domains Reveals a Complementary Role for the Two Proteins in Nucleotide Excision Repair Structure, 13, 2005
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1TZ4
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![BU of 1tz4 by Molmil](/molmil-images/mine/1tz4) | [hPP19-23]-pNPY bound to DPC Micelles | Descriptor: | neuropeptide Y,Pancreatic prohormone,neuropeptide Y | Authors: | Lerch, M, Kamimori, H, Folkers, G, Aguilar, M.I, Beck-Sickinger, A.G, Zerbe, O. | Deposit date: | 2004-07-09 | Release date: | 2005-07-05 | Last modified: | 2020-01-01 | Method: | SOLUTION NMR | Cite: | Strongly Altered Receptor Binding Properties in PP and NPY Chimeras Are Accompanied by Changes
in Structure and Membrane Binding Biochemistry, 44, 2005
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1TZ5
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![BU of 1tz5 by Molmil](/molmil-images/mine/1tz5) | [pNPY19-23]-hPP bound to DPC Micelles | Descriptor: | Pancreatic prohormone,neuropeptide Y,Pancreatic prohormone | Authors: | Lerch, M, Kamimori, H, Folkers, G, Aguilar, M.I, Beck-Sickinger, A.G, Zerbe, O. | Deposit date: | 2004-07-09 | Release date: | 2005-07-05 | Last modified: | 2020-01-01 | Method: | SOLUTION NMR | Cite: | Strongly Altered Receptor Binding Properties in PP and NPY Chimeras Are Accompanied by Changes
in Structure and Membrane Binding Biochemistry, 44, 2005
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1KKC
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![BU of 1kkc by Molmil](/molmil-images/mine/1kkc) | Crystal structure of Aspergillus fumigatus MnSOD | Descriptor: | MANGANESE (II) ION, Manganese Superoxide Dismutase | Authors: | Fluckiger, S, Mittl, P.R.E, Scapozza, L, Fijten, H, Folkers, G, Grutter, M.G, Blaser, K, Crameri, R. | Deposit date: | 2001-12-07 | Release date: | 2001-12-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Comparison of the crystal structures of the human manganese superoxide dismutase and the homologous Aspergillus fumigatus allergen at 2-A resolution. J.Immunol., 168, 2002
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2C3B
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![BU of 2c3b by Molmil](/molmil-images/mine/2c3b) | The Crystal Structure of Aspergillus fumigatus Cyclophilin reveals 3D Domain Swapping of a Central Element | Descriptor: | PPIASE, SULFATE ION | Authors: | Limacher, A, Kloer, D.P, Fluckiger, S, Folkers, G, Crameri, R, Scapozza, L. | Deposit date: | 2005-10-05 | Release date: | 2006-01-30 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | The Crystal Structure of Aspergillus Fumigatus Cyclophilin Reveals 3D Domain Swapping of a Central Element Structure, 14, 2006
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2AQ0
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![BU of 2aq0 by Molmil](/molmil-images/mine/2aq0) | Solution structure of the human homodimeric dna repair protein XPF | Descriptor: | DNA repair endonuclease XPF | Authors: | Das, D, Tripsianes, K, Folkers, G, Jaspers, N.G, Hoeijmakers, J.H, Kaptein, R, Boelens, R. | Deposit date: | 2005-08-17 | Release date: | 2006-10-03 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The HhH domain of the human DNA repair protein XPF forms stable homodimers Proteins, 70, 2008
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1OF1
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![BU of 1of1 by Molmil](/molmil-images/mine/1of1) | KINETICS AND CRYSTAL STRUCTURE OF THE HERPES SIMPLEX VIRUS TYPE 1 THYMIDINE KINASE INTERACTING WITH (SOUTH)-METHANOCARBA-THYMIDINE | Descriptor: | (SOUTH)-METHANOCARBA-THYMIDINE, SULFATE ION, THYMIDINE KINASE | Authors: | Claus, M.T, Schelling, P, Folkers, G, Marquez, V.E, Scapozza, L, Schulz, G.E. | Deposit date: | 2003-04-03 | Release date: | 2004-06-03 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Biochemical and Structural Characterization of (South)-Methanocarbathymidine that Specifically Inhibits Growth of Herpes Simplex Virus Type 1 Thymidine Kinase-Transduced Osteosarcoma Cells J.Biol.Chem., 279, 2004
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3VTK
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![BU of 3vtk by Molmil](/molmil-images/mine/3vtk) | |
2VTK
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![BU of 2vtk by Molmil](/molmil-images/mine/2vtk) | |
1VTK
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![BU of 1vtk by Molmil](/molmil-images/mine/1vtk) | |
3F0T
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![BU of 3f0t by Molmil](/molmil-images/mine/3f0t) | Crystal structure of thymidine kinase from Herpes simplex virus type 1 in complex with N-methyl-DHBT | Descriptor: | N-Methyl-6-(1,3-dihydroxy-isobutyl)thymine, SULFATE ION, Thymidine kinase | Authors: | Pernot, L, Perozzo, R, Westermaier, Y, Martic, M, Ametamey, S, Scapozza, L. | Deposit date: | 2008-10-26 | Release date: | 2009-11-03 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Synthesis, crystal structure, and in vitro biological evaluation of C-6 pyrimidine derivatives: new lead structures for monitoring gene expression in vivo. Nucleosides Nucleotides Nucleic Acids, 30, 2011
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1E2I
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![BU of 1e2i by Molmil](/molmil-images/mine/1e2i) | The nucleoside binding site of Herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography | Descriptor: | 9-HYDROXYPROPYLADENINE, R-ISOMER, S-ISOMER, ... | Authors: | Vogt, J, Scapozza, L, Schulz, G.E. | Deposit date: | 2000-05-23 | Release date: | 2000-11-06 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Nucleoside Binding Site of Herpes Simplex Type 1 Thymidine Kinase Analyzed by X-Ray Crystallography Proteins, 41, 2000
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1E2K
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![BU of 1e2k by Molmil](/molmil-images/mine/1e2k) | Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine | Descriptor: | 1-[4-HYDROXY-5-(HYDROXYMETHYL)BICYCLO[3.1.0]HEX-2-YL]-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE, SULFATE ION, THYMIDINE KINASE | Authors: | Vogt, J, Scapozza, L, Schulz, G.E. | Deposit date: | 2000-05-23 | Release date: | 2000-08-19 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Kinetics and Crystal Structure of the Wild-Type and the Engineered Y101F Mutant of Herpes Simplex Virus Type 1 Thymidine Kinase Interacting with (North)-Methanocarba-Thymidine Biochemistry, 39, 2000
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1E2J
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![BU of 1e2j by Molmil](/molmil-images/mine/1e2j) | The nucleoside binding site of Herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography | Descriptor: | SULFATE ION, THYMIDINE, THYMIDINE KINASE | Authors: | Vogt, J, Scapozza, L, Schulz, G.E. | Deposit date: | 2000-05-23 | Release date: | 2000-11-06 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Nucleoside Binding Site of Herpes Simplex Type 1 Thymidine Kinase Analyzed by X-Ray Crystallography Proteins: Struct.,Funct., Genet., 41, 2000
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1E2H
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![BU of 1e2h by Molmil](/molmil-images/mine/1e2h) | The nucleoside binding site of Herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography | Descriptor: | SULFATE ION, THYMIDINE KINASE | Authors: | Vogt, J, Scapozza, L, Schulz, G.E. | Deposit date: | 2000-05-23 | Release date: | 2000-11-06 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Nucleoside Binding Site of Herpes Simplex Type 1 Thymidine Kinase Analyzed by X-Ray Crystallography Proteins: Struct.,Funct., Genet., 41, 2000
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1E2N
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![BU of 1e2n by Molmil](/molmil-images/mine/1e2n) | HPT + HMTT | Descriptor: | 6-{[4-(HYDROXYMETHYL)-5-METHYL-2,6-DIOXOHEXAHYDROPYRIMIDIN-5-YL]METHYL}-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE, SULFATE ION, THYMIDINE KINASE | Authors: | Vogt, J, Scapozza, L, Schulz, G.E. | Deposit date: | 2000-05-23 | Release date: | 2001-03-31 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The Effect of Substrate Binding on the Conformation and Structural Stability of Herpes Simplex Virus Type 1 Thymidine Kinase Protein Sci., 10, 2001
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1E2P
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![BU of 1e2p by Molmil](/molmil-images/mine/1e2p) | Thymidine kinase, DHBT | Descriptor: | 6-[3-HYDROXY-2-(HYDROXYMETHYL)PROPYL]-5-METHYL-2,4(1H,3H)-PYRIMIDINEDIONE, SULFATE ION, THYMIDINE KINASE | Authors: | Schulz, G.E, Kessler, U. | Deposit date: | 2000-05-23 | Release date: | 2001-04-26 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The Effect of Substrate Binding on the Conformation and Structural Stability of Herpes Simplex Virus Type 1 Thymidine Kinase Protein Sci., 10, 2001
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1E2L
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![BU of 1e2l by Molmil](/molmil-images/mine/1e2l) | Kinetics and crystal structure of the wild-type and the engineered Y101F mutant of Herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine | Descriptor: | 1-[4-HYDROXY-5-(HYDROXYMETHYL)BICYCLO[3.1.0]HEX-2-YL]-5-METHYLPYRIMIDINE-2,4(1H,3H)-DIONE, SULFATE ION, THYMIDINE KINASE | Authors: | Vogt, J, Scapozza, L, Schulz, G.E. | Deposit date: | 2000-05-23 | Release date: | 2000-08-18 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Kinetics and Crystal Structure of the Wild-Type and the Engineered Y101F Mutant of Herpes Simplex Virus Type 1 Thymidine Kinase Interacting with (North)-Methanocarba-Thymidine Biochemistry, 39, 2000
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1E2M
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![BU of 1e2m by Molmil](/molmil-images/mine/1e2m) | HPT + HMTT | Descriptor: | 6-HYDROXYPROPYLTHYMINE, SULFATE ION, THYMIDINE KINASE | Authors: | Vogt, J, Scapozza, L, Schulz, G.E. | Deposit date: | 2000-05-23 | Release date: | 2001-03-31 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The Effect of Substrate Binding on the Conformation and Structural Stability of Herpes Simplex Virus Type 1 Thymidine Kinase Protein Sci., 10, 2001
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2JPD
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![BU of 2jpd by Molmil](/molmil-images/mine/2jpd) | Solution structure of the ERCC1 central domain | Descriptor: | DNA excision repair protein ERCC-1 | Authors: | Tripsianes, K, Folkers, G, Zheng, C, Das, D, Grinstead, J.S, Kaptein, R, Boelens, R. | Deposit date: | 2007-05-06 | Release date: | 2007-09-04 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Analysis of the XPA and ssDNA-binding surfaces on the central domain of human ERCC1 reveals evidence for subfunctionalization Nucleic Acids Res., 35, 2007
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2KEK
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![BU of 2kek by Molmil](/molmil-images/mine/2kek) | Solution structure of a dimer of LAC repressor DNA-binding domain complexed to its natural operator O3 | Descriptor: | DNA (5'-D(*CP*GP*GP*CP*AP*GP*TP*GP*AP*GP*CP*GP*CP*AP*AP*CP*GP*CP*AP*AP*TP*TP*C)-3'), DNA (5'-D(P*GP*AP*AP*TP*TP*GP*CP*GP*TP*TP*GP*CP*GP*CP*TP*CP*AP*CP*TP*GP*CP*CP*G)-3'), Lactose operon repressor | Authors: | Romanuka, J, Folkers, G, Biris, N, Tishchenko, E, Wienk, H, Kaptein, R, Boelens, R. | Deposit date: | 2009-01-30 | Release date: | 2009-05-19 | Last modified: | 2021-10-20 | Method: | SOLUTION NMR | Cite: | Specificity and affinity of Lac repressor for the auxiliary operators O2 and O3 are explained by the structures of their protein-DNA complexes. J.Mol.Biol., 390, 2009
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2KEI
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![BU of 2kei by Molmil](/molmil-images/mine/2kei) | Refined Solution Structure of a Dimer of LAC repressor DNA-Binding domain complexed to its natural operator O1 | Descriptor: | DNA (5'-D(*GP*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*GP*GP*AP*TP*AP*AP*CP*AP*AP*TP*TP*T)-3'), DNA (5'-D(P*AP*AP*AP*TP*TP*GP*TP*TP*AP*TP*CP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*TP*C)-3'), Lactose operon repressor | Authors: | Romanuka, J, Folkers, G, Biris, N, Tishchenko, E, Wienk, H, Kaptein, R, Boelens, R. | Deposit date: | 2009-01-30 | Release date: | 2009-05-19 | Last modified: | 2021-10-20 | Method: | SOLUTION NMR | Cite: | Specificity and affinity of Lac repressor for the auxiliary operators O2 and O3 are explained by the structures of their protein-DNA complexes. J.Mol.Biol., 390, 2009
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2KEJ
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![BU of 2kej by Molmil](/molmil-images/mine/2kej) | Solution structure of a dimer of LAC repressor DNA-binding domain complexed to its natural operator O2 | Descriptor: | DNA (5'-D(*GP*AP*AP*AP*TP*GP*TP*GP*AP*GP*CP*GP*AP*GP*TP*AP*AP*CP*AP*AP*CP*CP*G)-3'), DNA (5'-D(P*CP*GP*GP*TP*TP*GP*TP*TP*AP*CP*TP*CP*GP*CP*TP*CP*AP*CP*AP*TP*TP*TP*C)-3'), Lactose operon repressor | Authors: | Romanuka, J, Folkers, G, Biris, N, Tishchenko, E, Wienk, H, Kaptein, R, Boelens, R. | Deposit date: | 2009-01-30 | Release date: | 2009-05-19 | Last modified: | 2021-10-20 | Method: | SOLUTION NMR | Cite: | Specificity and affinity of Lac repressor for the auxiliary operators O2 and O3 are explained by the structures of their protein-DNA complexes. J.Mol.Biol., 390, 2009
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