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8VFU
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BU of 8vfu by Molmil
The Fab Crystal Structure of the PAN IL-1 Family Inhibitor Antibody 3G5
Descriptor: 3G5 Heavy Chain, 3G5 Light Chain
Authors:Fields, J.K, Sundberg, E.J.
Deposit date:2023-12-22
Release date:2024-02-21
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Antibodies targeting the shared cytokine receptor IL-1 receptor accessory protein invoke distinct mechanisms to block all cytokine signaling.
Cell Rep, 43, 2024
7LBL
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BU of 7lbl by Molmil
Structure of Human IgG1 Fc
Descriptor: Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Fields, J.K, Sundberg, E.J.
Deposit date:2021-01-08
Release date:2021-01-20
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Silent Antibodies: Generation of Hyperglycosylated FCs to Ablate Effector Functions
To Be Published
7LFN
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BU of 7lfn by Molmil
Structure of Hyperglycosylated Human IgG1 Fc (Fc267_329)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, IgG1 Fc (Fc267_329), alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Fields, J.K, Sundberg, E.J.
Deposit date:2021-01-17
Release date:2021-01-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Silent Antibodies: Generation of Hyperglycosylated FCs to Ablate Effector Functions
To Be Published
7LF9
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BU of 7lf9 by Molmil
Structure of Hyperglycosylated Human IgG1 Fc (Fc329)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IgG1 Fc (Fc329), ...
Authors:Fields, J.K, Sundberg, E.J.
Deposit date:2021-01-15
Release date:2021-01-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Silent Antibodies: Generation of Hyperglycosylated FCs to Ablate Effector Functions
To Be Published
7LF5
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BU of 7lf5 by Molmil
Structure of Hyperglycosylated Human IgG1 Fc (Fc267)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IgG1 Fc (Fc267), alpha-L-fucopyranose, ...
Authors:Fields, J.K, Sundberg, E.J.
Deposit date:2021-01-15
Release date:2021-01-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Silent Antibodies: Generation of Hyperglycosylated FCs to Ablate Effector Functions
To Be Published
8G6H
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BU of 8g6h by Molmil
H2BK120ub+H3K79me2-modified nucleosome ubiquitin position 6
Descriptor: 601 DNA (185-MER), Histone H2A, Histone H2B 1.1, ...
Authors:Hicks, C.W, Wolberger, C.
Deposit date:2023-02-15
Release date:2024-02-21
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:Ubiquitinated H2B as gatekeeper of the nucleosome acidic patch
To Be Published
6E58
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BU of 6e58 by Molmil
Crystal structure of Streptococcus pyogenes endo-beta-N-acetylglucosaminidase (EndoS2)
Descriptor: CALCIUM ION, Secreted Endo-beta-N-acetylglucosaminidase (EndoS)
Authors:Klontz, E.H, Trastoy, B, Gunther, S, Guerin, M.E, Sundberg, E.J.
Deposit date:2018-07-19
Release date:2019-02-06
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Molecular Basis of Broad SpectrumN-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2.
ACS Cent Sci, 5, 2019
8G6G
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BU of 8g6g by Molmil
H2BK120ub+H3K79me2-modified nucleosome ubiquitin position 5
Descriptor: 601 DNA (185-MER), Histone H2A, Histone H2B 1.1, ...
Authors:Hicks, C.W, Wolberger, C.
Deposit date:2023-02-15
Release date:2024-02-21
Method:ELECTRON MICROSCOPY (2.93 Å)
Cite:Ubiquitinated H2B as gatekeeper of the nucleosome acidic patch
To Be Published
8G6Q
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BU of 8g6q by Molmil
H2AK119ub-modified nucleosome ubiquitin position 1
Descriptor: 601 DNA (145-MER), Histone H2A, Histone H2B 1.1, ...
Authors:Hicks, C.W, Wolberger, C.
Deposit date:2023-02-15
Release date:2024-02-21
Method:ELECTRON MICROSCOPY (3.41 Å)
Cite:Ubiquitinated H2B as gatekeeper of the nucleosome acidic patch
To Be Published
8G6S
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BU of 8g6s by Molmil
H2AK119ub-modified nucleosome ubiquitin position 2
Descriptor: 601 DNA (145-MER), Histone H2A, Histone H2B 1.1, ...
Authors:Hicks, C.W, Wolberger, C.
Deposit date:2023-02-15
Release date:2024-02-21
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Ubiquitinated H2B as gatekeeper of the nucleosome acidic patch
To Be Published
6MDS
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BU of 6mds by Molmil
Crystal structure of Streptococcus pyogenes endo-beta-N-acetylglucosaminidase (EndoS2) with complex biantennary glycan
Descriptor: CALCIUM ION, Endo-beta-N-acetylglucosaminidase, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Klontz, E.H, Trastoy, B, Orwenyo, J, Wang, L.X, Guerin, M.E, Sundberg, E.J.
Deposit date:2018-09-05
Release date:2019-02-06
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular Basis of Broad SpectrumN-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2.
ACS Cent Sci, 5, 2019
6MDV
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BU of 6mdv by Molmil
Crystal structure of Streptococcus pyogenes endo-beta-N-acetylglucosaminidase (EndoS2) with high-mannose glycan
Descriptor: CALCIUM ION, Endo-beta-N-acetylglucosaminidase, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Klontz, E.H, Trastoy, B, Orwenyo, J, Wang, L.X, Guerin, M.E, Sundberg, E.J.
Deposit date:2018-09-05
Release date:2019-02-06
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular Basis of Broad SpectrumN-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2.
ACS Cent Sci, 5, 2019
6O1C
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BU of 6o1c by Molmil
Alpha-L-fucosidase AlfC D200A mutant in complex with 4-nitrophenyl-a-L-fucopyranoside substrate
Descriptor: 4-nitrophenyl 6-deoxy-alpha-L-galactopyranoside, AlfC
Authors:Klontz, E.H, Sundberg, E.J.
Deposit date:2019-02-19
Release date:2020-02-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure and dynamics of an alpha-fucosidase reveal a mechanism for highly efficient IgG transfucosylation.
Nat Commun, 11, 2020
6O1A
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BU of 6o1a by Molmil
Alpha-L-fucosidase AlfC from Lactobacillus casei in complex with alpha-L-fucose product
Descriptor: AlfC, beta-L-fucopyranose
Authors:Klontz, E.H, Sundberg, E.J.
Deposit date:2019-02-18
Release date:2020-02-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure and dynamics of an alpha-fucosidase reveal a mechanism for highly efficient IgG transfucosylation.
Nat Commun, 11, 2020
6O1J
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BU of 6o1j by Molmil
Alpha-L-fucosidase AlfC fucosyltransferase mutant N243A
Descriptor: AlfC, beta-L-fucopyranose
Authors:Klontz, E.H, Sundberg, E.J.
Deposit date:2019-02-20
Release date:2020-02-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and dynamics of an alpha-fucosidase reveal a mechanism for highly efficient IgG transfucosylation.
Nat Commun, 11, 2020
6O18
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BU of 6o18 by Molmil
Unliganded alpha-L-fucosidase AlfC from Lactobacillus casei
Descriptor: AlfC
Authors:Klontz, E.H, Sundberg, E.J.
Deposit date:2019-02-18
Release date:2020-02-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure and dynamics of an alpha-fucosidase reveal a mechanism for highly efficient IgG transfucosylation.
Nat Commun, 11, 2020
6O1I
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BU of 6o1i by Molmil
Alpha-L-fucosidase AlfC fucosyltransferase mutant E274A
Descriptor: AlfC
Authors:Klontz, E.H, Sundberg, E.J.
Deposit date:2019-02-20
Release date:2020-02-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.55 Å)
Cite:Structure and dynamics of an alpha-fucosidase reveal a mechanism for highly efficient IgG transfucosylation.
Nat Commun, 11, 2020
6OHE
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BU of 6ohe by Molmil
Alpha-L-fucosidase AlfC D200A in complex with Fuca(1,6)GlcNAc
Descriptor: AlfC, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Klontz, E.H, Sundberg, E.J.
Deposit date:2019-04-05
Release date:2020-04-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:Structure and dynamics of an alpha-fucosidase reveal a mechanism for highly efficient IgG transfucosylation.
Nat Commun, 11, 2020
8TTM
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BU of 8ttm by Molmil
IgG1 Fc Heterodimer combYSelect1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin gamma-1 heavy chain
Authors:Azzam, T, Du, J.J, Sundberg, E.J.
Deposit date:2023-08-14
Release date:2024-06-26
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Combinatorially restricted computational design of protein-protein interfaces to produce IgG heterodimers.
Sci Adv, 10, 2024
8TUD
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BU of 8tud by Molmil
IgG1 Fc Heterodimer combYSelect2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin gamma-1 heavy chain
Authors:Azzam, T, Du, J.J, Sundberg, E.J.
Deposit date:2023-08-16
Release date:2024-06-26
Method:X-RAY DIFFRACTION (3 Å)
Cite:Combinatorially restricted computational design of protein-protein interfaces to produce IgG heterodimers.
Sci Adv, 10, 2024
5VAW
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BU of 5vaw by Molmil
Fusion of Maltose-binding Protein and PilA from Acinetobacter baumannii AB5075
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, GLUTAMIC ACID, LYSINE, ...
Authors:Piepenbrink, K.H, Sundberg, E.J.
Deposit date:2017-03-28
Release date:2018-03-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:The structure of PilA fromAcinetobacter baumanniiAB5075 suggests a mechanism for functional specialization inAcinetobactertype IV pili.
J. Biol. Chem., 294, 2019

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