6MDS
Crystal structure of Streptococcus pyogenes endo-beta-N-acetylglucosaminidase (EndoS2) with complex biantennary glycan
Summary for 6MDS
Entry DOI | 10.2210/pdb6mds/pdb |
Descriptor | Endo-beta-N-acetylglucosaminidase, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (4 entities in total) |
Functional Keywords | glycoside hydrolase, endo-beta-n-acetylglucosaminidase s2, endoglycosidase s2, endos2, hydrolase |
Biological source | Streptococcus pyogenes |
Total number of polymer chains | 2 |
Total formula weight | 184721.30 |
Authors | Klontz, E.H.,Trastoy, B.,Orwenyo, J.,Wang, L.X.,Guerin, M.E.,Sundberg, E.J. (deposition date: 2018-09-05, release date: 2019-02-06, Last modification date: 2023-10-11) |
Primary citation | Klontz, E.H.,Trastoy, B.,Deredge, D.,Fields, J.K.,Li, C.,Orwenyo, J.,Marina, A.,Beadenkopf, R.,Gunther, S.,Flores, J.,Wintrode, P.L.,Wang, L.X.,Guerin, M.E.,Sundberg, E.J. Molecular Basis of Broad SpectrumN-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2. ACS Cent Sci, 5:524-538, 2019 Cited by PubMed: 30937380DOI: 10.1021/acscentsci.8b00917 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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