6MDS
Crystal structure of Streptococcus pyogenes endo-beta-N-acetylglucosaminidase (EndoS2) with complex biantennary glycan
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0033925 | molecular_function | mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity |
| A | 0042783 | biological_process | symbiont-mediated evasion of host immune response |
| A | 0043655 | cellular_component | host extracellular space |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0033925 | molecular_function | mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity |
| B | 0042783 | biological_process | symbiont-mediated evasion of host immune response |
| B | 0043655 | cellular_component | host extracellular space |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PROSITE/UniProt
| site_id | PS01095 |
| Number of Residues | 9 |
| Details | GH18_1 Glycosyl hydrolases family 18 (GH18) active site signature. VDGLDIDiE |
| Chain | Residue | Details |
| A | VAL178-GLU186 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU10053, ECO:0000305|PubMed:23865566 |
| Chain | Residue | Details |
| A | GLU186 | |
| B | GLU186 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:30937380, ECO:0007744|PDB:6MDS, ECO:0007744|PDB:6MDV |
| Chain | Residue | Details |
| A | ARG72 | |
| B | ARG72 | |
| B | TRP74 | |
| B | ASP108 | |
| B | HIS109 | |
| B | TYR252 | |
| B | GLU288 | |
| B | GLU289 | |
| B | ASN295 | |
| B | TYR339 | |
| A | TRP74 | |
| A | ASP108 | |
| A | HIS109 | |
| A | TYR252 | |
| A | GLU288 | |
| A | GLU289 | |
| A | ASN295 | |
| A | TYR339 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:30937380, ECO:0007744|PDB:6MDV |
| Chain | Residue | Details |
| A | HIS88 | |
| B | HIS88 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:30937380, ECO:0007744|PDB:6MDS |
| Chain | Residue | Details |
| A | HIS107 | |
| A | ASP184 | |
| A | GLN250 | |
| B | HIS107 | |
| B | ASP184 | |
| B | GLN250 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:30937380, ECO:0007744|PDB:6E58, ECO:0007744|PDB:6MDS, ECO:0007744|PDB:6MDV |
| Chain | Residue | Details |
| A | LYS699 | |
| B | ASP707 | |
| B | THR824 | |
| B | GLU825 | |
| A | ASP702 | |
| A | GLU704 | |
| A | ASP707 | |
| A | THR824 | |
| A | GLU825 | |
| B | LYS699 | |
| B | ASP702 | |
| B | GLU704 |
