6MDS

Crystal structure of Streptococcus pyogenes endo-beta-N-acetylglucosaminidase (EndoS2) with complex biantennary glycan

Summary for 6MDS

Entry DOI	10.2210/pdb6mds/pdb
Descriptor	Endo-beta-N-acetylglucosaminidase, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (4 entities in total)
Functional Keywords	glycoside hydrolase, endo-beta-n-acetylglucosaminidase s2, endoglycosidase s2, endos2, hydrolase
Biological source	Streptococcus pyogenes
Total number of polymer chains	2
Total formula weight	184721.30
Authors	Klontz, E.H.,Trastoy, B.,Orwenyo, J.,Wang, L.X.,Guerin, M.E.,Sundberg, E.J. (deposition date: 2018-09-05, release date: 2019-02-06, Last modification date: 2023-10-11)
Primary citation	Klontz, E.H.,Trastoy, B.,Deredge, D.,Fields, J.K.,Li, C.,Orwenyo, J.,Marina, A.,Beadenkopf, R.,Gunther, S.,Flores, J.,Wintrode, P.L.,Wang, L.X.,Guerin, M.E.,Sundberg, E.J. Molecular Basis of Broad SpectrumN-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2. ACS Cent Sci, 5:524-538, 2019 Cited by PubMed: 30937380 DOI: 10.1021/acscentsci.8b00917 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation