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6V6G
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BU of 6v6g by Molmil
Crystal structure of CTX-M-14 E166A/P167S/D240G beta-lactamase
Descriptor: Beta-lactamase, DI(HYDROXYETHYL)ETHER, SODIUM ION
Authors:Brown, C.A, Hu, L, Sankaran, B, Prasad, B.V.V, Palzkill, T.G.
Deposit date:2019-12-05
Release date:2020-04-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Antagonism between substitutions in beta-lactamase explains a path not taken in the evolution of bacterial drug resistance.
J.Biol.Chem., 295, 2020
6V6P
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BU of 6v6p by Molmil
Crystal structure of CTX-M-14 E166A/D240G beta-lactamase
Descriptor: Beta-lactamase, DI(HYDROXYETHYL)ETHER, SULFATE ION
Authors:Brown, C.A, Hu, L, Sankaran, B, Prasad, B.V.V, Palzkill, T.G.
Deposit date:2019-12-05
Release date:2020-04-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Antagonism between substitutions in beta-lactamase explains a path not taken in the evolution of bacterial drug resistance.
J.Biol.Chem., 295, 2020
6V8V
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BU of 6v8v by Molmil
Crystal structure of CTX-M-14 E166A/P167S/D240G beta-lactamase in complex with ceftazidime-2
Descriptor: ACYLATED CEFTAZIDIME, Beta-lactamase
Authors:Brown, C.A, Hu, L, Sankaran, B, Prasad, B.V.V, Palzkill, T.G.
Deposit date:2019-12-12
Release date:2020-04-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Antagonism between substitutions in beta-lactamase explains a path not taken in the evolution of bacterial drug resistance.
J.Biol.Chem., 295, 2020
6V83
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BU of 6v83 by Molmil
Crystal structure of CTX-M-14 E166A/P167S/D240G beta-lactamase in complex with ceftazidime-1
Descriptor: ACYLATED CEFTAZIDIME, Beta-lactamase
Authors:Brown, C.A, Hu, L, Sankaran, B, Prasad, B.V.V, Palzkill, T.G.
Deposit date:2019-12-10
Release date:2020-04-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Antagonism between substitutions in beta-lactamase explains a path not taken in the evolution of bacterial drug resistance.
J.Biol.Chem., 295, 2020
6V5E
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BU of 6v5e by Molmil
Crystal structure of CTX-M-14 P167S/D240G beta-lactamase
Descriptor: Beta-lactamase
Authors:Brown, C.A, Hu, L, Sankaran, B, Prasad, B.V.V, Palzkill, T.G.
Deposit date:2019-12-04
Release date:2020-04-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Antagonism between substitutions in beta-lactamase explains a path not taken in the evolution of bacterial drug resistance.
J.Biol.Chem., 295, 2020
6V7T
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BU of 6v7t by Molmil
Crystal structure of CTX-M-14 E166A/D240G beta-lactamase in complex with ceftazidime
Descriptor: ACYLATED CEFTAZIDIME, Beta-lactamase
Authors:Brown, C.A, Hu, L, Sankaran, B, Prasad, B.V.V, Palzkill, T.G.
Deposit date:2019-12-09
Release date:2020-04-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Antagonism between substitutions in beta-lactamase explains a path not taken in the evolution of bacterial drug resistance.
J.Biol.Chem., 295, 2020
5INJ
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BU of 5inj by Molmil
Crystal Structure of Prenyltransferase PriB Ternary Complex with L-Tryptophan and Dimethylallyl thiolodiphosphate (DMSPP)
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DIMETHYLALLYL S-THIOLODIPHOSPHATE, Prenyltransferase, ...
Authors:Cao, H, Elshahawi, S, Benach, J, Wasserman, S.R, Morisco, L.L, Koss, J.W, Thorson, J.S, Phillips Jr, G.N, Enzyme Discovery for Natural Product Biosynthesis (NatPro)
Deposit date:2016-03-07
Release date:2016-05-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure and specificity of a permissive bacterial C-prenyltransferase.
Nat. Chem. Biol., 13, 2017
3D4L
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BU of 3d4l by Molmil
Human dipeptidyl peptidase IV/CD26 in complex with a novel inhibitor
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Scapin, G.
Deposit date:2008-05-14
Release date:2008-07-01
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design.
Bioorg.Med.Chem.Lett., 18, 2008
8DZ8
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BU of 8dz8 by Molmil
Neoleukin 4, a de novo designed IL-4 mimetic
Descriptor: neoleukin-4
Authors:Jude, K.M, Spangler, J.B, Garcia, K.C.
Deposit date:2022-08-06
Release date:2023-03-29
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.972 Å)
Cite:Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds.
Nat.Chem.Biol., 19, 2023
8EOB
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BU of 8eob by Molmil
Cryo-EM structure of human HSP90B in the closed state
Descriptor: Heat shock protein HSP 90-beta, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Srivastava, D, Artemyev, N.O.
Deposit date:2022-10-02
Release date:2023-01-25
Last modified:2023-03-15
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Unique interface and dynamics of the complex of HSP90 with a specialized cochaperone AIPL1.
Structure, 31, 2023
8EOA
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BU of 8eoa by Molmil
Cryo-EM structure of human HSP90B-AIPL1 complex
Descriptor: Aryl-hydrocarbon-interacting protein-like 1, Heat shock protein HSP 90-beta, MAGNESIUM ION, ...
Authors:Srivastava, D, Artemyev, N.O.
Deposit date:2022-10-02
Release date:2023-01-25
Last modified:2023-03-15
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Unique interface and dynamics of the complex of HSP90 with a specialized cochaperone AIPL1.
Structure, 31, 2023
5Z5W
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BU of 5z5w by Molmil
VFR12 in complex with LPS micelles
Descriptor: Peptide from Prothrombin
Authors:Saravanan, R, Schmidtchen, A.
Deposit date:2018-01-21
Release date:2018-03-07
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides.
Nat Commun, 9, 2018
5Z5X
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BU of 5z5x by Molmil
HVF18 in complex with LPS micelles
Descriptor: Peptide from Prothrombin
Authors:Saravanan, R, Schmidtchen, A.
Deposit date:2018-01-21
Release date:2018-03-07
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structural basis for endotoxin neutralisation and anti-inflammatory activity of thrombin-derived C-terminal peptides.
Nat Commun, 9, 2018
1IVG
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BU of 1ivg by Molmil
STRUCTURES OF AROMATIC INHIBITORS OF INFLUENZA VIRUS NEURAMINIDASE
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, INFLUENZA A SUBTYPE N2 NEURAMINIDASE, ...
Authors:Jedrzejas, M.J, Luo, M.
Deposit date:1994-12-12
Release date:1995-03-31
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of aromatic inhibitors of influenza virus neuraminidase.
Biochemistry, 34, 1995
7DLD
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BU of 7dld by Molmil
Crystal structures of (S)-carbonyl reductases from Candida parapsilosis in different oligomerization states
Descriptor: Carbonyl Reductase, MAGNESIUM ION
Authors:Li, Y.H, Zhang, R.Z, Forouhar, F, Wang, C, Montelione, G.T, Szyperski, T, Xu, Y, Hunt, J.F.
Deposit date:2020-11-27
Release date:2022-04-06
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Oligomeric interactions maintain active-site structure in a noncooperative enzyme family.
Embo J., 41, 2022
7DLM
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BU of 7dlm by Molmil
Short chain dehydrogenase (SCR) crystal structure with NADPH
Descriptor: Carbonyl Reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Li, Y.H, Zhang, R.Z, Forouhar, F, Wang, C, Montelione, G.T, Szyperski, T, Xu, Y, Hunt, J.F.
Deposit date:2020-11-28
Release date:2022-04-06
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Oligomeric interactions maintain active-site structure in a noncooperative enzyme family.
Embo J., 41, 2022
7DLL
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BU of 7dll by Molmil
Short chain dehydrogenase 2 (SCR2) crystal structure with NADPH
Descriptor: (S)-specific carbonyl reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Li, Y.H, Zhang, R.Z, Forouhar, F, Wang, C, Montelione, G.T, Szyperski, T, Xu, Y, Hunt, J.F.
Deposit date:2020-11-28
Release date:2022-04-06
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Oligomeric interactions maintain active-site structure in a noncooperative enzyme family.
Embo J., 41, 2022
7DMG
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BU of 7dmg by Molmil
Short chain dehydrogenase 2 (SCR2) crystal structure with NADP
Descriptor: (S)-specific carbonyl reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Li, Y.H, Zhang, R.Z, Forouhar, F, Wang, C, Montelione, G.T, Szyperski, T, Xu, Y, Hunt, J.F.
Deposit date:2020-12-03
Release date:2022-04-06
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Oligomeric interactions maintain active-site structure in a noncooperative enzyme family.
Embo J., 41, 2022
7DN1
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BU of 7dn1 by Molmil
Hetero-oligomers of SCR-SCR2 crystal structure with NADPH
Descriptor: (S)-specific carbonyl reductase, Carbonyl Reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Li, Y.H, Zhang, R.Z, Forouhar, F, Wang, C, Montelione, G.T, Szyperski, T, Xu, Y, Hunt, J.F.
Deposit date:2020-12-08
Release date:2022-04-06
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Oligomeric interactions maintain active-site structure in a noncooperative enzyme family.
Embo J., 41, 2022
8SZX
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BU of 8szx by Molmil
Crystal structure of b'-WD40 Lys17Ala mutant
Descriptor: Coatomer subunit beta'
Authors:Dey, D, Hasan, S.S.
Deposit date:2023-05-30
Release date:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:A single C-terminal residue controls SARS-CoV-2 spike trafficking and incorporation into VLPs.
Nat Commun, 14, 2023
8SK5
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BU of 8sk5 by Molmil
Crystal structure of the SARS-CoV-2 neutralizing VHH 7A9 bound to the spike receptor binding domain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, anti-SARS-CoV-2 receptor binding domain VHH
Authors:Noland, C.L, Pande, K, Zhang, L, Zhou, H, Galli, J, Eddins, M, Gomez-Llorente, Y.
Deposit date:2023-04-18
Release date:2023-08-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.011 Å)
Cite:Discovery and multimerization of cross-reactive single-domain antibodies against SARS-like viruses to enhance potency and address emerging SARS-CoV-2 variants.
Sci Rep, 13, 2023
5TVS
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BU of 5tvs by Molmil
JMJD2A in complex with Ni(II)
Descriptor: Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION
Authors:Cascella, B, Lee, S.G, Jez, J.M.
Deposit date:2016-11-09
Release date:2017-02-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.745 Å)
Cite:The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A.
Chem. Commun. (Camb.), 53, 2017
5TVR
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BU of 5tvr by Molmil
JMJD2A in complex with Ni(II) and alpha-Ketoglutarate
Descriptor: 2-OXOGLUTARIC ACID, Lysine-specific demethylase 4A, NICKEL (II) ION, ...
Authors:Cascella, B, Lee, S.G, Jez, J.M.
Deposit date:2016-11-09
Release date:2017-02-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.093 Å)
Cite:The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A.
Chem. Commun. (Camb.), 53, 2017
2P8S
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BU of 2p8s by Molmil
Human dipeptidyl peptidase IV/CD26 in complex with a cyclohexalamine inhibitor
Descriptor: (1S,2R,5S)-5-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-2-(2,4,5-TRIFLUOROPHENYL)CYCLOHEXANAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Scapin, G, Biftu, T.
Deposit date:2007-03-23
Release date:2007-05-22
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin
Bioorg.Med.Chem.Lett., 17, 2007
1XMT
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BU of 1xmt by Molmil
X-ray structure of gene product from arabidopsis thaliana at1g77540
Descriptor: BROMIDE ION, putative acetyltransferase
Authors:Wesenberg, G.E, Smith, D.W, Phillips Jr, G.N, Bitto, E, Bingman, C.A, Allard, S.T.M, Center for Eukaryotic Structural Genomics (CESG)
Deposit date:2004-10-04
Release date:2004-10-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Structure of Arabidopsis thaliana At1g77540 Protein, a Minimal Acetyltransferase from the COG2388 Family.
Biochemistry, 45, 2006

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