5TVR

JMJD2A in complex with Ni(II) and alpha-Ketoglutarate

Summary for 5TVR

Entry DOI	10.2210/pdb5tvr/pdb
Related	5TVS
Descriptor	Lysine-specific demethylase 4A, NICKEL (II) ION, 2-OXOGLUTARIC ACID, ... (5 entities in total)
Functional Keywords	oxidoreductase demethylase monooxygenase epigenetics, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	84075.49
Authors	Cascella, B.,Lee, S.G.,Jez, J.M. (deposition date: 2016-11-09, release date: 2017-02-01, Last modification date: 2023-10-04)
Primary citation	Cascella, B.,Lee, S.G.,Singh, S.,Jez, J.M.,Mirica, L.M. The small molecule JIB-04 disrupts O2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A. Chem. Commun. (Camb.), 53:2174-2177, 2017 Cited by PubMed: 28144654 DOI: 10.1039/c6cc09882g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.093 Å)

Structure validation