8DYH
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![BU of 8dyh by Molmil](/molmil-images/mine/8dyh) | IL17A homodimer bound to Compound 6 | Descriptor: | (5P)-N-benzyl-6-chloro-5-(quinolin-5-yl)pyridin-3-amine, GLYCEROL, Interleukin-17A | Authors: | Argiriadi, M.A, Goedken, E.R. | Deposit date: | 2022-08-04 | Release date: | 2022-09-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site. Sci Rep, 12, 2022
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8DYI
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![BU of 8dyi by Molmil](/molmil-images/mine/8dyi) | IL17A homodimer bound to Compound 5 | Descriptor: | (5P)-5-[5-(benzylamino)pyridin-3-yl]-N-[2-(morpholin-4-yl)ethyl]-1H-indazol-3-amine, Interleukin-17A | Authors: | Argiriadi, M.A, Goedken, E.R. | Deposit date: | 2022-08-04 | Release date: | 2022-09-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site. Sci Rep, 12, 2022
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8DYF
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![BU of 8dyf by Molmil](/molmil-images/mine/8dyf) | IL17A homodimer bound to Compound 10 | Descriptor: | (5M)-3-[({2-[2-(2-{2-[2-({[(5M)-3-carboxy-5-(5,8-dihydroquinolin-4-yl)phenyl]amino}methyl)phenoxy]ethoxy}ethoxy)ethoxy]phenyl}methyl)amino]-5-(quinolin-4-yl)benzoic acid, Interleukin-17A | Authors: | Argiriadi, M.A, Goedken, E.R. | Deposit date: | 2022-08-04 | Release date: | 2022-09-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site. Sci Rep, 12, 2022
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3ZQC
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![BU of 3zqc by Molmil](/molmil-images/mine/3zqc) | Structure of the Trichomonas vaginalis Myb3 DNA-binding domain bound to a promoter sequence reveals a unique C-terminal beta-hairpin conformation | Descriptor: | MRE-1, MYB3 | Authors: | Wei, S.-Y, Lou, Y.-C, Tsai, J.-Y, Hsu, H.-M, Tai, J.-H, Hsiao, C.-D, Chen, C. | Deposit date: | 2011-06-09 | Release date: | 2012-04-18 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structure of the Trichomonas Vaginalis Myb3 DNA-Binding Domain Bound to a Promoter Sequence Reveals a Unique C-Terminal Beta-Hairpin Conformation. Nucleic Acids Res., 40, 2012
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2IF2
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![BU of 2if2 by Molmil](/molmil-images/mine/2if2) | Crystal Structure of the Putative Dephospho-CoA Kinase from Aquifex aeolicus, Northeast Structural Genomics Target QR72. | Descriptor: | 1,2-ETHANEDIOL, Dephospho-CoA kinase, SULFATE ION | Authors: | Forouhar, F, Hussain, M, Seetharaman, J, Hussain, A, Wu, M, Fang, Y, Cunningham, K, Ma, L.C, Xiao, R, Liu, J, Baran, M, Rost, B, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2006-09-19 | Release date: | 2006-10-03 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: |
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6FL5
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![BU of 6fl5 by Molmil](/molmil-images/mine/6fl5) | Structure of human SHMT1-H135N-R137A-E168N mutant at 3.6 Ang. resolution | Descriptor: | CHLORIDE ION, PYRIDOXAL-5'-PHOSPHATE, Serine hydroxymethyltransferase, ... | Authors: | Giardina, G, Cutruzzola, F, Lucchi, R. | Deposit date: | 2018-01-25 | Release date: | 2018-10-10 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells. FEBS J., 285, 2018
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2HFD
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![BU of 2hfd by Molmil](/molmil-images/mine/2hfd) | NMR structure of protein Hydrogenase-1 operon protein hyaE from Escherichia coli: Northeast Structural Genomics Consortium Target ER415 | Descriptor: | Hydrogenase-1 operon protein hyaE | Authors: | Singarapu, K.K, Liu, G, Eletsky, A, Parish, D, Atreya, H.S, Xu, D, Janjua, H, Cunningham, K, Ma, L.C, Xiao, R, Liu, J, Baran, M, Swapna, G.V.T, Acton, T, Rost, B, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2006-06-23 | Release date: | 2006-08-22 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Protein chaperones Q8ZP25_SALTY from Salmonella typhimurium and HYAE_ECOLI from Escherichia coli exhibit thioredoxin-like structures despite lack of canonical thioredoxin active site sequence motif. J.STRUCT.FUNCT.GENOM., 9, 2008
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7RNW
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![BU of 7rnw by Molmil](/molmil-images/mine/7rnw) | |
2JXM
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![BU of 2jxm by Molmil](/molmil-images/mine/2jxm) | Ensemble of twenty structures of the Prochlorothrix hollandica plastocyanin- cytochrome f complex | Descriptor: | COPPER (II) ION, Cytochrome f, HEME C, ... | Authors: | Hulsker, R, Baranova, M, Bullerjahn, G, Ubbink, M. | Deposit date: | 2007-11-22 | Release date: | 2008-02-12 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Dynamics in the transient complex of plastocyanin-cytochrome f from Prochlorothrix hollandica. J.Am.Chem.Soc., 130, 2008
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5AGC
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![BU of 5agc by Molmil](/molmil-images/mine/5agc) | Crystallographic forms of the Vps75 tetramer | Descriptor: | VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 75 | Authors: | Hammond, C.M, Sundaramoorthy, R, Owen-Hughes, T. | Deposit date: | 2015-01-29 | Release date: | 2016-03-02 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | The Histone Chaperone Vps75 Forms Multiple Oligomeric Assemblies Capable of Mediating Exchange between Histone H3-H4 Tetramers and Asf1-H3-H4 Complexes. Nucleic Acids Res., 44, 2016
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4R28
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![BU of 4r28 by Molmil](/molmil-images/mine/4r28) | |
3GHE
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![BU of 3ghe by Molmil](/molmil-images/mine/3ghe) | |
2JN7
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![BU of 2jn7 by Molmil](/molmil-images/mine/2jn7) | Northeast Structural Genomics Consortium Target ER411 | Descriptor: | protein yfjZ | Authors: | Tian, F, Zhao, L, Jiang, M, Cunningham, K, Ma, L, Xiao, R, Liu, J, Baran, M, Swapna, G.V.T, Acton, T.B, Rost, B, Montelione, G.T, Prestegard, J.H, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2006-12-28 | Release date: | 2007-01-09 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | NMR solution structure of E.Coli hypothetical protein YFJZ To be Published
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2M6Q
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![BU of 2m6q by Molmil](/molmil-images/mine/2m6q) | Refined Solution NMR Structure of Staphylococcus aureus protein SAV1430. Northeast Strucutral Genomics Consortium Target ZR18 | Descriptor: | SAV1430 | Authors: | Baran, M.C, Aramini, J.M, Huang, Y.J, Xiao, R, Acton, T.B, Shih, L, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2013-04-08 | Release date: | 2013-05-01 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | PDBStat: a universal restraint converter and restraint analysis software package for protein NMR. J.Biomol.Nmr, 56, 2013
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3GHB
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![BU of 3ghb by Molmil](/molmil-images/mine/3ghb) | |
4PVF
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![BU of 4pvf by Molmil](/molmil-images/mine/4pvf) | Crystal structure of Homo sapiens holo serine hydroxymethyltransferase 2 (mitochondrial) (SHMT2), isoform 3, transcript variant 5, 483 aa, at 2.6 ang. resolution | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Serine hydroxymethyltransferase, ... | Authors: | Giardina, G, Brunotti, P, Fiascarelli, A, Contestabile, R, Cutruzzola, F. | Deposit date: | 2014-03-17 | Release date: | 2015-01-28 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state. Febs J., 282, 2015
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7JJD
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![BU of 7jjd by Molmil](/molmil-images/mine/7jjd) | |
7JJE
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![BU of 7jje by Molmil](/molmil-images/mine/7jje) | |
7JJF
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![BU of 7jjf by Molmil](/molmil-images/mine/7jjf) | Sarcin-ricin loop with modified residue. | Descriptor: | MAGNESIUM ION, RNA/DNA (27-mer) | Authors: | Harp, J.M, Pallan, P.S, Egli, M. | Deposit date: | 2020-07-25 | Release date: | 2020-12-23 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Incorporating a Thiophosphate Modification into a Common RNA Tetraloop Motif Causes an Unanticipated Stability Boost. Biochemistry, 59, 2020
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1Y9M
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![BU of 1y9m by Molmil](/molmil-images/mine/1y9m) | Crystal structure of exo-inulinase from Aspergillus awamori in spacegroup P212121 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | Authors: | Nagem, R.A.P, Rojas, A.L, Golubev, A.M, Korneeva, O.S, Eneyskaya, E.V, Kulminskaya, A.A, Neustroev, K.N, Polikarpov, I. | Deposit date: | 2004-12-16 | Release date: | 2004-12-28 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Crystal structure of exo-inulinase from Aspergillus awamori: the enzyme fold and structural determinants of substrate recognition J.Mol.Biol., 344, 2004
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1Y9G
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![BU of 1y9g by Molmil](/molmil-images/mine/1y9g) | Crystal structure of exo-inulinase from Aspergillus awamori complexed with fructose | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-fructofuranose, ... | Authors: | Nagem, R.A.P, Rojas, A.L, Golubev, A.M, Korneeva, O.S, Eneyskaya, E.V, Kulminskaya, A.A, Neustroev, K.N, Polikarpov, I. | Deposit date: | 2004-12-15 | Release date: | 2004-12-21 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Crystal structure of exo-inulinase from Aspergillus awamori: the enzyme fold and structural determinants of substrate recognition J.Mol.Biol., 344, 2004
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1Y4W
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![BU of 1y4w by Molmil](/molmil-images/mine/1y4w) | Crystal structure of exo-inulinase from Aspergillus awamori in spacegroup P21 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | Authors: | Nagem, R.A.P, Rojas, A.L, Golubev, A.M, Korneeva, O.S, Eneyskaya, E.V, Kulminskaya, A.A, Neustroev, K.N, Polikarpov, I. | Deposit date: | 2004-12-01 | Release date: | 2004-12-14 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Crystal structure of exo-inulinase from Aspergillus awamori: the enzyme fold and structural determinants of substrate recognition J.Mol.Biol., 344, 2004
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2HEQ
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![BU of 2heq by Molmil](/molmil-images/mine/2heq) | NMR Structure of Bacillus subtilis protein YorP, Northeast Structural Genomics Target SR399. | Descriptor: | YorP protein | Authors: | Ramelot, T.A, Cort, J.R, Wang, D, Janjua, H, Cunningham, K, Ma, L.-C, Xiao, R, Liu, J, Baran, M, Swapna, G.V.T, Acton, T.B, Rost, B, Montelione, G.M, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2006-06-21 | Release date: | 2006-08-15 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | NMR Structure of Bacillus subtilis protein YorP, Northeast Structural Genomics Target SR399. To be Published
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2ID1
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![BU of 2id1 by Molmil](/molmil-images/mine/2id1) | X-Ray Crystal Structure of Protein CV0518 from Chromobacterium violaceum, Northeast Structural Genomics Consortium Target CvR5. | Descriptor: | Hypothetical protein, IODIDE ION | Authors: | Forouhar, F, Zhou, W, Seetharaman, J, Ho, C.K, Janjua, H, Cunningham, K, Ma, L.C, Xiao, R, Liu, J, Baran, M, Acton, T.B, Rost, B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2006-09-13 | Release date: | 2006-09-26 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: |
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2M87
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![BU of 2m87 by Molmil](/molmil-images/mine/2m87) | |