4CSU
 
 | | Cryo-EM structures of the 50S ribosome subunit bound with ObgE | | Descriptor: | 23S RRNA, 50S RIBOSOMAL PROTEIN L1, 50S RIBOSOMAL PROTEIN L11, ... | | Authors: | Feng, B, Mandava, C.S, Guo, Q, Wang, J, Cao, W, Li, N, Zhang, Y, Zhang, Y, Wang, Z, Wu, J, Sanyal, S, Lei, J, Gao, N. | | Deposit date: | 2014-03-10 | | Release date: | 2014-06-04 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (5.5 Å) | | Cite: | Structural and Functional Insights Into the Mode of Action of a Universally Conserved Obg Gtpase.
Plos Biol., 12, 2014
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1J55
 | | The Crystal Structure of Ca+-bound Human S100P Determined at 2.0A Resolution by X-ray | | Descriptor: | CALCIUM ION, S-100P PROTEIN | | Authors: | Zhang, H, Wang, G, Ding, Y, Wang, Z, Barraclough, R, Rudland, P.S, Fernig, D.G, Rao, Z. | | Deposit date: | 2002-01-25 | | Release date: | 2003-01-07 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The Crystal Structure at 2A Resolution of the Ca2+-binding Protein S100P
J.Mol.Biol., 325, 2003
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4TTH
 | | Crystal structure of a CDK6/Vcyclin complex with inhibitor bound | | Descriptor: | 9-cyclopentyl-N-(5-piperazin-1-ylpyridin-2-yl)pyrido[4,5]pyrrolo[1,2-d]pyrimidin-2-amine, Cyclin homolog, Cyclin-dependent kinase 6 | | Authors: | Piper, D.E, Walker, N, Wang, Z. | | Deposit date: | 2014-06-20 | | Release date: | 2014-08-06 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3.
J.Med.Chem., 57, 2014
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2YJY
 | | A specific and modular binding code for cytosine recognition in PUF domains | | Descriptor: | 5'-R(*AP*UP*UP*GP*CP*AP*UP*AP*UP*AP)-3', PUMILIO HOMOLOG 1 | | Authors: | Dong, S, Wang, Y, Cassidy-Amstutz, C, Lu, G, Qiu, C, Bigler, R, Jezyk, M, Li, C, Hall, T.M.T, Wang, Z. | | Deposit date: | 2011-05-24 | | Release date: | 2011-06-08 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.598 Å) | | Cite: | Specific and Modular Binding Code for Cytosine Recognition in Pumilio/Fbf (Puf) RNA-Binding Domains.
J.Biol.Chem., 286, 2011
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4DUM
 | | Co-crystal structure of eIF4E with inhibitor | | Descriptor: | (4-{7-[2-(4-chlorophenoxy)ethyl]-2-(methylamino)-6-oxo-6,7-dihydro-1H-purin-8-yl}phenyl)phosphonic acid, 1,2-ETHANEDIOL, Eukaryotic translation initiation factor 4E | | Authors: | Min, X, Johnstone, S, Walker, N, Wang, Z. | | Deposit date: | 2012-02-22 | | Release date: | 2012-04-11 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Structure-Guided Design, Synthesis, and Evaluation of Guanine-Derived Inhibitors of the eIF4E mRNA-Cap Interaction.
J.Med.Chem., 55, 2012
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8JQ9
 | | Novel Anti-phage System | | Descriptor: | Endonuclease GajA | | Authors: | Li, J, Wang, Z, Wang, L. | | Deposit date: | 2023-06-13 | | Release date: | 2024-02-28 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (2.66 Å) | | Cite: | Structures and activation mechanism of the Gabija anti-phage system.
Nature, 629, 2024
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8JQC
 | | Novel Anti-phage System | | Descriptor: | Endonuclease GajA, Gabija protein GajB | | Authors: | Li, J, Wang, Z, Wang, L. | | Deposit date: | 2023-06-13 | | Release date: | 2024-02-28 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.39 Å) | | Cite: | Structures and activation mechanism of the Gabija anti-phage system.
Nature, 629, 2024
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8JQB
 | | Structure of Gabija GajA-GajB 4:4 Complex | | Descriptor: | Endonuclease GajA, Gabija protein GajB | | Authors: | Li, J, Wang, Z, Wang, L. | | Deposit date: | 2023-06-13 | | Release date: | 2024-02-28 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structures and activation mechanism of the Gabija anti-phage system.
Nature, 629, 2024
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5KQA
 | | Crystal structure of buckwheat glutaredoxin-glutathione complex | | Descriptor: | GLUTATHIONE, Glutaredoxin-glutathione complex | | Authors: | Zhang, X, Wang, W, Zhao, Y, Wang, Z, Wang, H. | | Deposit date: | 2016-07-06 | | Release date: | 2017-07-05 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structural insights into the binding of buckwheat glutaredoxin with GSH and regulation of its catalytic activity
J. Inorg. Biochem., 173, 2017
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5J5C
 | | Crystal structure of ARL1-GTP and DCB domain of BIG1 complex | | Descriptor: | ADP-ribosylation factor-like protein 1, Brefeldin A-inhibited guanine nucleotide-exchange protein 1, GUANOSINE-5'-TRIPHOSPHATE, ... | | Authors: | Wang, R, Wang, Z, Zhang, T, Ding, J. | | Deposit date: | 2016-04-02 | | Release date: | 2016-09-28 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Structural basis for targeting BIG1 to Golgi apparatus through interaction of its DCB domain with Arl1
J Mol Cell Biol, 2016
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8WY5
 | | Structure of Gabija GajA in complex with DNA | | Descriptor: | CALCIUM ION, DNA (5'-D(P*AP*AP*AP*AP*TP*AP*AP*CP*CP*GP*GP*GP*TP*TP*AP*TP*TP*AP*A)-3'), DNA (5'-D(P*TP*TP*AP*AP*TP*AP*AP*CP*CP*CP*GP*GP*TP*TP*AP*TP*TP*TP*T)-3'), ... | | Authors: | Li, J, Wang, Z, Wang, L. | | Deposit date: | 2023-10-30 | | Release date: | 2024-02-28 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.12 Å) | | Cite: | Structures and activation mechanism of the Gabija anti-phage system.
Nature, 629, 2024
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1A40
 | | PHOSPHATE-BINDING PROTEIN WITH ALA 197 REPLACED WITH TRP | | Descriptor: | PHOSPHATE ION, PHOSPHATE-BINDING PERIPLASMIC PROTEIN PRECURSOR | | Authors: | Ledivina, P.S, Wang, Z, Tsai, A, Koehl, E, Quiocho, F.A. | | Deposit date: | 1998-02-10 | | Release date: | 1999-03-23 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Dominant role of local dipolar interactions in phosphate binding to a receptor cleft with an electronegative charge surface: equilibrium, kinetic, and crystallographic studies.
Protein Sci., 7, 1998
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6JOY
 | | The X-ray Crystallographic Structure of Branching Enzyme from Rhodothermus obamensis STB05 | | Descriptor: | 1,4-alpha-glucan branching enzyme GlgB | | Authors: | Li, Z.F, Ban, X.F, Jiang, H.M, Wang, Z, Jin, T.C, Li, C.M, Gu, Z.B. | | Deposit date: | 2019-03-25 | | Release date: | 2020-03-04 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.392 Å) | | Cite: | Flexible Loop in Carbohydrate-Binding Module 48 Allosterically Modulates Substrate Binding of the 1,4-alpha-Glucan Branching Enzyme.
J.Agric.Food Chem., 69, 2021
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6PQQ
 | | Cryo-EM structure of human TRPA1 C621S mutant in the apo state | | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily A member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | | Authors: | Suo, Y, Wang, Z, Zubcevic, L, Hsu, A.L, He, Q, Borgnia, M.J, Ji, R.-R, Lee, S.-Y. | | Deposit date: | 2019-07-09 | | Release date: | 2020-01-08 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (2.81 Å) | | Cite: | Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel.
Neuron, 105, 2020
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6PQO
 | | Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist JT010 | | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-chloro-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-N-(3-methoxypropyl)acetamide, ... | | Authors: | Suo, Y, Wang, Z, Zubcevic, L, Hsu, A.L, He, Q, Borgnia, M.J, Ji, R.-R, Lee, S.-Y. | | Deposit date: | 2019-07-09 | | Release date: | 2020-01-08 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (2.88 Å) | | Cite: | Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel.
Neuron, 105, 2020
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6Q04
 | | MERS-CoV S structure in complex with 5-N-acetyl neuraminic acid | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FOLIC ACID, ... | | Authors: | Park, Y.J, Walls, A.C, Wang, Z, Sauer, M, Li, W, Tortorici, M.A, Bosch, B.J, DiMaio, F.D, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | | Deposit date: | 2019-08-01 | | Release date: | 2019-12-11 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors.
Nat.Struct.Mol.Biol., 26, 2019
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6Q06
 | | MERS-CoV S structure in complex with 2,3-sialyl-N-acetyl-lactosamine | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FOLIC ACID, ... | | Authors: | Park, Y.J, Walls, A.C, Wang, Z, Sauer, M, Li, W, Tortorici, M.A, Bosch, B.J, DiMaio, F.D, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | | Deposit date: | 2019-08-01 | | Release date: | 2019-12-11 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors.
Nat.Struct.Mol.Biol., 26, 2019
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6Q05
 | | MERS-CoV S structure in complex with sialyl-lewisX | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FOLIC ACID, ... | | Authors: | Park, Y.J, Walls, A.C, Wang, Z, Sauer, M, Li, W, Tortorici, M.A, Bosch, B.J, DiMaio, F.D, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | | Deposit date: | 2019-08-01 | | Release date: | 2019-12-11 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors.
Nat.Struct.Mol.Biol., 26, 2019
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6Q07
 | | MERS-CoV S structure in complex with 2,6-sialyl-N-acetyl-lactosamine | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FOLIC ACID, ... | | Authors: | Park, Y.J, Walls, A.C, Wang, Z, Sauer, M, Li, W, Tortorici, M.A, Bosch, B.J, DiMaio, F.D, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | | Deposit date: | 2019-08-01 | | Release date: | 2019-12-11 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors.
Nat.Struct.Mol.Biol., 26, 2019
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6O9H
 | | Mouse ECD with Fab1 | | Descriptor: | Gastric inhibitory polypeptide receptor, Heavy chain, Light chain, ... | | Authors: | Min, X, Wang, Z. | | Deposit date: | 2019-03-13 | | Release date: | 2020-01-22 | | Last modified: | 2020-04-01 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor.
Mabs, 12, 2020
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5JMT
 | | Crystal structure of Zika virus NS3 helicase | | Descriptor: | NS3 helicase | | Authors: | Tian, H, Ji, X, Yang, X, Xie, W, Yang, K, Chen, C, Wu, C, Chi, H, Mu, Z, Wang, Z, Yang, H. | | Deposit date: | 2016-04-29 | | Release date: | 2016-05-25 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.796 Å) | | Cite: | The crystal structure of Zika virus helicase: basis for antiviral drug design
Protein Cell, 7, 2016
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6O9I
 | | Ternary complex of mouse ECD with Fab1 and Fab2 | | Descriptor: | 1,2-ETHANEDIOL, Fab 2 heavy chain, Fab1 heavy chain, ... | | Authors: | Min, X, Wang, Z. | | Deposit date: | 2019-03-13 | | Release date: | 2020-01-22 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor.
Mabs, 12, 2020
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8JTN
 | | Tudor domain of TDRD3 in complex with a small molecule | | Descriptor: | 2-propyl-2-azoniatricyclo[7.3.0.0^{3,7}]dodeca-1(9),2,7-trien-8-amine, Tudor domain-containing protein 3 | | Authors: | Chen, M, Wang, Z, Li, W, Shang, X, Liu, Y. | | Deposit date: | 2023-06-22 | | Release date: | 2023-08-09 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of Tudor domain of TDRD3 in complex with a small molecule antagonist.
Biochim Biophys Acta Gene Regul Mech, 1866, 2023
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6CXC
 | | 3.9A Cryo-EM structure of murine antibody bound at a novel epitope of respiratory syncytial virus fusion protein | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, Envelope glycoprotein chimera, ... | | Authors: | Xie, Q, Wang, Z, Chen, X, Ni, F, Ma, J, Wang, Q. | | Deposit date: | 2018-04-02 | | Release date: | 2019-07-31 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structure basis of neutralization by a novel site II/IV antibody against respiratory syncytial virus fusion protein.
Plos One, 14, 2019
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1N5U
 | | X-RAY STUDY OF HUMAN SERUM ALBUMIN COMPLEXED WITH HEME | | Descriptor: | MYRISTIC ACID, PROTOPORPHYRIN IX CONTAINING FE, SERUM ALBUMIN | | Authors: | Wardell, M, Wang, Z, Ho, J.X, Robert, J, Ruker, F, Ruble, J, Carter, D.C. | | Deposit date: | 2002-11-07 | | Release date: | 2003-06-24 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The Atomic Structure of Human Methemalbumin at 1.9 A
Biochem.Biophys.Res.Commun., 291, 2002
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