2WS9
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![BU of 2ws9 by Molmil](/molmil-images/mine/2ws9) | Equine Rhinitis A Virus at Low pH | Descriptor: | P1 | Authors: | Fry, E.E, Tuthill, T.J, Harlos, K, Walter, T.S, Knowles, N.J, Gropelli, E, Rowlands, D.J, Stuart, D.I. | Deposit date: | 2009-09-04 | Release date: | 2010-08-25 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Equine Rhinitis a Virus and its Low Ph Empty Particle: Clues Towards an Aphthovirus Entry Mechanism? Plos Pathog., 5, 2009
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2X10
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![BU of 2x10 by Molmil](/molmil-images/mine/2x10) | Crystal structure of the complete EphA2 ectodomain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, EPHRIN TYPE-A RECEPTOR 2 | Authors: | Seiradake, E, Harlos, K, Sutton, G, Aricescu, A.R, Jones, E.Y. | Deposit date: | 2009-12-21 | Release date: | 2010-03-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | An Extracellular Steric Seeding Mechanism for Eph-Ephrin Signalling Platform Assembly Nat.Struct.Mol.Biol., 17, 2010
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2WG4
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![BU of 2wg4 by Molmil](/molmil-images/mine/2wg4) | Crystal structure of the complex between human hedgehog-interacting protein HIP and sonic hedgehog without calcium | Descriptor: | HEDGEHOG-INTERACTING PROTEIN, SODIUM ION, SONIC HEDGEHOG PROTEIN N-PRODUCT, ... | Authors: | Bishop, B, Aricescu, A.R, Harlos, K, O'Callaghan, C.A, Jones, E.Y, Siebold, C. | Deposit date: | 2009-04-15 | Release date: | 2009-06-30 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Structural Insights Into Hedgehog Ligand Sequestration by the Human Hedgehog-Interacting Protein Hip Nat.Struct.Mol.Biol., 16, 2009
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1GZQ
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![BU of 1gzq by Molmil](/molmil-images/mine/1gzq) | CD1b in complex with Phophatidylinositol | Descriptor: | 2-[(HYDROXY{[(2R,3R,5S,6R)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXYL]OXY}PHOSPHORYL)OXY]-1-[(PALMITOYLOXY)METHYL]ETHYL HEPTADECANOATE, B2-MICROGLOBULIN, DOCOSANE, ... | Authors: | Gadola, S.D, Zaccai, N.R, Harlos, K, Shepherd, D, Ritter, G, Schmidt, R.R, Jones, E.Y, Cerundolo, V. | Deposit date: | 2002-05-24 | Release date: | 2002-07-31 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Structure of Human Cd1B with Bound Ligands at 2.3 A, a Maze for Alkyl Chains Nat.Immunol., 3, 2002
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2WFF
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![BU of 2wff by Molmil](/molmil-images/mine/2wff) | Equine Rhinitis A Virus | Descriptor: | P1 | Authors: | Fry, E.E, Tuthill, T.J, Harlos, K, Walter, T.S, Knowles, N.J, Gropelli, E, Rowlands, D.J, Stuart, D.I. | Deposit date: | 2009-04-05 | Release date: | 2010-05-05 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Equine Rhinitis a Virus and its Low Ph Empty Particle: Clues Towards an Aphthovirus Entry Mechanism? Plos Pathog., 5, 2009
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2WNG
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![BU of 2wng by Molmil](/molmil-images/mine/2wng) | complete extracellular structure of human signal regulatory protein (SIRP) alpha | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE SUBSTRATE 1 | Authors: | Hatherley, D, Graham, S.C, Harlos, K, Stuart, D.I, Barclay, A.N. | Deposit date: | 2009-07-09 | Release date: | 2009-07-21 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Structure of Signal-Regulatory Protein Alpha: A Link to Antigen Receptor Evolution. J.Biol.Chem., 284, 2009
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2WJW
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![BU of 2wjw by Molmil](/molmil-images/mine/2wjw) | Crystal structure of the human ionotropic glutamate receptor GluR2 ATD region at 1.8 A resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, CHLORIDE ION, ... | Authors: | Clayton, A, Siebold, C, Gilbert, R.J.C, Sutton, G.C, Harlos, K, McIlhinney, R.A.J, Jones, E.Y, Aricescu, A.R. | Deposit date: | 2009-06-01 | Release date: | 2009-08-18 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of the Glur2 Amino-Terminal Domain Provides Insights Into the Architecture and Assembly of Ionotropic Glutamate Receptors. J.Mol.Biol., 392, 2009
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1H4I
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![BU of 1h4i by Molmil](/molmil-images/mine/1h4i) | Methylobacterium extorquens methanol dehydrogenase | Descriptor: | CALCIUM ION, METHANOL DEHYDROGENASE SUBUNIT 1, METHANOL DEHYDROGENASE SUBUNIT 2, ... | Authors: | Ghosh, M, Anthony, C, Harlos, K, Goodwin, M.G, Blake, C. | Deposit date: | 2001-05-11 | Release date: | 2001-06-14 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | The Refined Structure of the Quinoprotein Methanol Dehydrogenase from Methylobacterium Extorquens at 1.94 A. Structure, 3, 1995
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2X46
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![BU of 2x46 by Molmil](/molmil-images/mine/2x46) | Crystal Structure of SeMet Arg r 1 | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ALLERGEN ARG R 1 | Authors: | Paesen, G.C, Siebold, C, Syme, N, Harlos, K, Graham, S.C, Hilger, C, Homans, S.W, Hentges, F, Stuart, D.I. | Deposit date: | 2010-01-28 | Release date: | 2011-02-09 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1 Å) | Cite: | Crystal Structure of the Allergen Arg R 1, a Histamine-Binding Lipocalin from a Soft Tick To be Published
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1GP0
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![BU of 1gp0 by Molmil](/molmil-images/mine/1gp0) | Human IGF2R domain 11 | Descriptor: | CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR, SULFATE ION | Authors: | Brown, J, Esnouf, R.M, Jones, M.A, Linnell, J, Harlos, K, Hassan, A.B, Jones, E.Y. | Deposit date: | 2001-10-29 | Release date: | 2002-02-28 | Last modified: | 2019-04-10 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structure of a Functional Igf2R Fragment Determined from the Anomalous Scattering of Sulfur Embo J., 21, 2002
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2XBO
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![BU of 2xbo by Molmil](/molmil-images/mine/2xbo) | Equine Rhinitis A Virus in Complex with its Sialic Acid Receptor | Descriptor: | N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose, P1 | Authors: | Fry, E.E, Tuthill, T.J, Harlos, K, Walter, T.S, Rowlands, D.J, Stuart, D.I. | Deposit date: | 2010-04-14 | Release date: | 2010-09-22 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | The Crystal Structure of Equine Rhinitis a Virus in Complex with its Sialic Acid Receptor. J.Gen.Virol., 91, 2010
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2X45
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![BU of 2x45 by Molmil](/molmil-images/mine/2x45) | Crystal Structure of Arg r 1 in complex with histamine | Descriptor: | ALLERGEN ARG R 1, HISTAMINE | Authors: | Paesen, G.C, Siebold, C, Syme, N, Harlos, K, Graham, S.C, Hilger, C, Homans, S.W, Hentges, F, Stuart, D.I. | Deposit date: | 2010-01-28 | Release date: | 2011-02-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Crystal Structure of the Allergen Arg R 1, a Histamine-Binding Lipocalin from a Soft Tick To be Published
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2X11
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![BU of 2x11 by Molmil](/molmil-images/mine/2x11) | Crystal structure of the complete EphA2 ectodomain in complex with ephrin A5 receptor binding domain | Descriptor: | EPHRIN TYPE-A RECEPTOR 2, EPHRIN-A5 | Authors: | Seiradake, E, Harlos, K, Sutton, G, Aricescu, A.R, Jones, E.Y. | Deposit date: | 2009-12-21 | Release date: | 2010-03-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (4.83 Å) | Cite: | An Extracellular Steric Seeding Mechanism for Eph-Ephrin Signalling Platform Assembly Nat.Struct.Mol.Biol., 17, 2010
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2WJX
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![BU of 2wjx by Molmil](/molmil-images/mine/2wjx) | Crystal structure of the human ionotropic glutamate receptor GluR2 ATD region at 4.1 A resolution | Descriptor: | GLUTAMATE RECEPTOR 2 | Authors: | Clayton, A, Siebold, C, Gilbert, R.J.C, Sutton, G.C, Harlos, K, McIlhinney, R.A.J, Jones, E.Y, Aricescu, A.R. | Deposit date: | 2009-06-01 | Release date: | 2009-08-18 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (4.1 Å) | Cite: | Crystal Structure of the Glur2 Amino-Terminal Domain Provides Insights Into the Architecture and Assembly of Ionotropic Glutamate Receptors. J.Mol.Biol., 392, 2009
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1IPS
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![BU of 1ips by Molmil](/molmil-images/mine/1ips) | ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (MANGANESE COMPLEX) | Descriptor: | ISOPENICILLIN N SYNTHASE, MANGANESE (II) ION | Authors: | Roach, P.L, Clifton, I.J, Fulop, V, Harlos, K, Barton, G.J, Hajdu, J, Andersson, I, Schofield, C.J, Baldwin, J.E. | Deposit date: | 1997-03-21 | Release date: | 1998-03-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes. Nature, 375, 1995
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7DPI
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![BU of 7dpi by Molmil](/molmil-images/mine/7dpi) | Plasmodium falciparum cytoplasmic Phenylalanyl-tRNA synthetase in complex with BRD7929 | Descriptor: | (8R,9S,10S)-10-[(dimethylamino)methyl]-N-(4-methoxyphenyl)-9-[4-(2-phenylethynyl)phenyl]-1,6-diazabicyclo[6.2.0]decane-6-carboxamide, MAGNESIUM ION, Phenylalanine--tRNA ligase, ... | Authors: | Manmohan, S, Malhotra, N, Harlos, K, Manickam, Y, Sharma, A. | Deposit date: | 2020-12-19 | Release date: | 2022-03-23 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (3.597 Å) | Cite: | Inhibition of Plasmodium falciparum phenylalanine tRNA synthetase provides opportunity for antimalarial drug development. Structure, 30, 2022
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7EL5
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![BU of 7el5 by Molmil](/molmil-images/mine/7el5) | |
7BY6
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![BU of 7by6 by Molmil](/molmil-images/mine/7by6) | Plasmodium vivax cytoplasmic Phenylalanyl-tRNA synthetase in complex with BRD1389 | Descriptor: | (3S,4R,8R,9R,10S)-N-(4-cyclopropyloxyphenyl)-10-(methoxymethyl)-3,4-bis(oxidanyl)-9-[4-(2-phenylethynyl)phenyl]-1,6-diazabicyclo[6.2.0]decane-6-carboxamide, MAGNESIUM ION, Phenylalanyl-tRNA synthetase beta chain, ... | Authors: | Malhotra, N, Manmohan, S, Harlos, K, Melillo, B, Schreiber, S.L, Manickam, Y, Sharma, S. | Deposit date: | 2020-04-21 | Release date: | 2020-11-04 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.997 Å) | Cite: | Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines. Nat Commun, 12, 2021
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7ODU
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![BU of 7odu by Molmil](/molmil-images/mine/7odu) | Natural killer cell receptor NKR-P1B from Rattus norvegicus in complex with its cognate ligand Clr-11 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C-type lectin domain family 2 member D11, ... | Authors: | Skalova, T, Blaha, J, Kalouskova, B, Skorepa, O, Vanek, O, Dohnalek, J. | Deposit date: | 2021-04-30 | Release date: | 2022-06-01 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Natural killer cell receptor NKR-P1B from Rattus norvegicus in complex with its cognate ligand Clr-11 To Be Published
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6Z30
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![BU of 6z30 by Molmil](/molmil-images/mine/6z30) | Human cation-independent mannose 6-phosphate/ IGF2 receptor domains 9-10 | Descriptor: | Cation-independent mannose-6-phosphate receptor, alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Bochel, A.J, Williams, C, Crump, M.P. | Deposit date: | 2020-05-19 | Release date: | 2020-08-19 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9. Structure, 28, 2020
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6J7V
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![BU of 6j7v by Molmil](/molmil-images/mine/6j7v) | |
6OTD
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![BU of 6otd by Molmil](/molmil-images/mine/6otd) | Globin sensor domain of AfGcHK in monomeric form, with imidazole | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Globin-coupled histidine kinase, IMIDAZOLE, ... | Authors: | Skalova, T, Dohnalek, J, Kolenko, P, Stranava, M, Lengalova, A, Martinkova, M. | Deposit date: | 2019-05-03 | Release date: | 2020-01-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Disruption of the dimerization interface of the sensing domain in the dimeric heme-based oxygen sensorAfGcHK abolishes bacterial signal transduction. J.Biol.Chem., 295, 2020
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6YJP
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![BU of 6yjp by Molmil](/molmil-images/mine/6yjp) | Crystal structure of a complex between glycosylated NKp30 and its deglycosylated tumour ligand B7-H6 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Natural cytotoxicity triggering receptor 3, Natural cytotoxicity triggering receptor 3 ligand 1 | Authors: | Skalova, T, Dohnalek, J, Skorepa, O, Kalouskova, B, Pazicky, S, Blaha, J, Vanek, O. | Deposit date: | 2020-04-04 | Release date: | 2020-07-29 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Natural Killer Cell Activation Receptor NKp30 Oligomerization Depends on Its N -Glycosylation. Cancers (Basel), 12, 2020
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5MJ6
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![BU of 5mj6 by Molmil](/molmil-images/mine/5mj6) | Ligand-induced conformational change of Insulin-regulated aminopeptidase: insights on catalytic mechanism and active site plasticity. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BROMIDE ION, ... | Authors: | Mpakali, A, Stratikos, E, Saridakis, E, Giastas, P. | Deposit date: | 2016-11-30 | Release date: | 2017-04-05 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity. J. Med. Chem., 60, 2017
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2IVI
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![BU of 2ivi by Molmil](/molmil-images/mine/2ivi) | Isopenicillin N Synthase From Aspergillus Nidulans (Anaerobic Ac- methyl-cyclopropylglycine Fe Complex) | Descriptor: | D-(L-A-AMINOADIPOYL)-L-CYSTEINYL-B-METHYL-D-CYCLOPROPYLGLYCINE, FE (II) ION, ISOPENICILLIN N SYNTHETASE, ... | Authors: | Elkins, J.M, Howard-Jones, A.R, Clifton, I.J, Roach, P.L, Adlington, R.M, Baldwin, J.E, Rutledge, P.J. | Deposit date: | 2006-06-13 | Release date: | 2007-04-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Interactions of Isopenicillin N Synthase with Cyclopropyl-Containing Substrate Analogues Reveal New Mechanistic Insight. Biochemistry, 46, 2007
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